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Immunotherapy-chemotherapy combo boosts survival for patients with metastatic colorectal cancer

A study led by UCLA Health Jonsson Comprehensive Cancer Center researchers found that using a combination of experimental immunotherapy drugs with chemotherapy significantly improves progression-free survival and overall survival for patients with metastatic colorectal cancer who have previously undergone standard chemotherapy treatment when compared to those who received the targeted therapy regorafenib alone.

24 May 2024

In-vivo imaging to quantify collagen morphology in preclinical melanoma models during immunotherapy

Collagen, a major component of the extracellular matrix, plays a crucial role in tumor development.

23 May 2024

New AI model sets benchmark in digital pathology with superior cancer diagnostics

Researchers developed Prov-GigaPath, a whole-slide pathology foundation model using a novel vision transformer architecture. The model demonstrates superior performance in mutation prediction, cancer subtyping, and vision-language tasks. It leverages large-scale real-world data from over 30,000 patients to enhance clinical diagnostics.

23 May 2024

Tailoring polymeric micelles for improved olaparib solubility and drug release

Olaparib is a selective poly (ADP-ribose) polymerase inhibitor. However, its clinical application is hindered by low solubility and undesired pharmacokinetic profiles (e.g., relatively short circulation).

23 May 2024

Evaluating the performance of 3D power Doppler in differential diagnosis of adnexal masses

Three-dimensional power Doppler (3DPD) ultrasound has been used for assessing adnexal masses, and in this study, we aimed to perform a meta-analysis to evaluate its role in the differential diagnosis of adnexal masses.

23 May 2024

New study advocates for de-escalating breast cancer surgery in women aged 55 and older

Surgery involving sentinel lymph node biopsy for middle-aged women with estrogen receptor-positive (ER+) breast cancer may do more harm than good, according to a new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers.

22 May 2024

Review highlights the rapidly evolving landscape of hepatocellular carcinoma treatment

Hepatocellular carcinoma (HCC), a prevalent form of cancer, profoundly influences the progression and prognosis of the disease through immune response mechanisms.

22 May 2024

Study suggests miR-377 as potential therapeutic target for prostate cancer

A new research paper was published in Genes & Cancer on May 16, 2024, entitled, "Inhibitory effect of miR-377 on the proliferative and invasive behaviors of prostate cancer cells through the modulation of MYC mRNA via its interaction with BCL-2/Bax, PTEN, and CDK4."

22 May 2024

Novel therapy reprograms immune cells, shrinks prostate and bladder cancers in animal study

A novel therapy that reprograms immune cells to promote antitumor activity helped shrink hard-to-treat prostate and bladder cancers in mice, according to research from the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy and Johns Hopkins Drug Discovery.

21 May 2024

Researchers decipher how immune cells spot cancer's turbocharged metabolism

When cells become tumor cells, their metabolism changes fundamentally. Researchers at the University of Basel and the University Hospital Basel have now demonstrated that this change leaves traces that could provide targets for cancer immunotherapies.

21 May 2024

Impact of CLK kinase inhibitors 1C8 and GPS167 on cancer cell proliferation and metastasis

A new research paper was published in Oncotarget's Volume 15 on May 16, 2024, entitled, "The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response."

20 May 2024

Ketogenic diets linked to cellular aging in vital organs, new study finds

Study reveals that ketogenic diets induce cellular senescence in mice, affecting organs like the kidneys and heart through AMPK and p53 pathways. These findings highlight potential long-term risks associated with ketogenic diets.

20 May 2024

Transportation of cancer nanomedicines into solid tumors

A new study conducted by the Wilhelm Lab at the University of Oklahoma examines a promising development in biomedical nanoengineering.

20 May 2024

Study identifies PI3K-beta as key target in overcoming chemotherapy resistance in glioblastoma

For many patients with a deadly type of brain cancer called glioblastoma, chemotherapy resistance is a big problem.

20 May 2024

Disabling survival pathways could be a promising strategy for brain tumor treatment

When you disable the brakes on a race car, it quickly crashes. Dr. Barak Rotblat wants to do something similar to brain cancer cells.

20 May 2024

Machine learning enhances early detection of glioma mutations

Machine learning (ML) methods can quickly and accurately diagnose mutations in gliomas – primary brain tumors.

20 May 2024

Cancer researchers urged to embrace AI for groundbreaking insights and efficiency

A review in Nature Reviews Cancer emphasizes the necessity for cancer researchers to understand AI's potentials and limitations, detailing its applications and challenges in cancer research to aid non-computational biologists.

20 May 2024

New study identifies key protein biomarkers for early detection of pancreatic cancer

Study used a Mendelian randomization approach to identify REG1A and REG1B as potential biomarkers for early detection of pancreatic cancer, showing their causal effects and significance in cancer screening.

19 May 2024

Gut bacteria Ruminococcus gnavus can enhance the effects of cancer immunotherapy

Roughly one in five cancer patients benefits from immunotherapy – a treatment that harnesses the immune system to fight cancer.

17 May 2024

Immune checkpoint protein VISTA can directly turn off T-cells during immunotherapy, study finds

A Cleveland Clinic-led team of scientists and physicians have discovered that the immune checkpoint protein VISTA can directly turn off tumor-fighting T-cells during immunotherapy and resist treatment.

17 May 2024

Tumor News and Research

Immunotherapy-chemotherapy combo boosts survival for patients with metastatic colorectal cancer

In-vivo imaging to quantify collagen morphology in preclinical melanoma models during immunotherapy

New AI model sets benchmark in digital pathology with superior cancer diagnostics

Tailoring polymeric micelles for improved olaparib solubility and drug release

Evaluating the performance of 3D power Doppler in differential diagnosis of adnexal masses

New study advocates for de-escalating breast cancer surgery in women aged 55 and older

Review highlights the rapidly evolving landscape of hepatocellular carcinoma treatment

Study suggests miR-377 as potential therapeutic target for prostate cancer

Novel therapy reprograms immune cells, shrinks prostate and bladder cancers in animal study

Researchers decipher how immune cells spot cancer's turbocharged metabolism

Impact of CLK kinase inhibitors 1C8 and GPS167 on cancer cell proliferation and metastasis

Ketogenic diets linked to cellular aging in vital organs, new study finds

Transportation of cancer nanomedicines into solid tumors

Study identifies PI3K-beta as key target in overcoming chemotherapy resistance in glioblastoma

Disabling survival pathways could be a promising strategy for brain tumor treatment

Machine learning enhances early detection of glioma mutations

Cancer researchers urged to embrace AI for groundbreaking insights and efficiency

New study identifies key protein biomarkers for early detection of pancreatic cancer

Gut bacteria Ruminococcus gnavus can enhance the effects of cancer immunotherapy

Immune checkpoint protein VISTA can directly turn off T-cells during immunotherapy, study finds

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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