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Novel gene-delivery vehicle shows promise for treating brain disorders

In an important step toward more effective gene therapies for brain diseases, researchers from the Broad Institute of MIT and Harvard have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver a disease-relevant gene to the brain in mice expressing the human protein.

16 May 2024

Mechanistic insights into the role of huc-mscs in treating acute liver failure

Acute liver failure (ALF) is a life-threatening clinical problem with limited treatment options. Administration of human umbilical cord mesenchymal stem cells (hUC-MSCs) may be a promising approach for ALF.

16 May 2024

New PET imaging biomarker Gal-1 predicts tumor responses to immunotherapy

The protein galectin-1 (Gal-1) has been identified as a new PET imaging biomarker for immune checkpoint blockade (ICB) therapy, allowing physicians to predict the tumor responses before beginning treatment.

15 May 2024

Sleep and anesthesia hinder brain toxin clearance, study reveals

Researchers found that brain clearance is reduced during both sleep and anesthesia, contradicting the belief that these states enhance toxin removal.

14 May 2024

Study proposes a novel therapeutic avenue for tackling EHF-induced cholangiocarcinogenesis

This study is led by Dr. Yiming Luo (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) and Professor. Huifang Liang (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology).

14 May 2024

Human cell-based model of thoracic aortic aneurysm offers new opportunities for drug development

Using human cells in laboratory rats, Michigan Medicine researchers have developed a functional model of thoracic aortic aneurysm, creating opportunities for more effective understanding of disease development and treatments for the potentially fatal condition, a study suggests.

14 May 2024

Machine learning unveils hidden gender differences in brain structure

Artificial intelligence (AI) computer programs that process MRI results show differences in how the brains of men and women are organized at a cellular level, a new study shows.

14 May 2024

New mechanism discovered to weaken pseudomonas aeruginosa virulence

The opportunistic bacterial pathogen Pseudomonas aeruginosa is dangerous due to its resistance to multiple antibiotics.

14 May 2024

Experimental gene therapy shows promise for treating herpes infections

Researchers at Fred Hutch Cancer Center have found in pre-clinical studies that an experimental gene therapy for genital and oral herpes removed 90% or more of the infection and suppressed how much virus can be released from an infected individual, which suggests that the therapy would also reduce the spread of the virus.

13 May 2024

Drug repurposing breakthrough: varespladib curbs snakebite-induced necrosis

Researchers discovered that venom toxins from African spitting cobras cause severe dermonecrosis, highlighting the need for targeted treatments like the repurposed drug varespladib.

9 May 2024

Enhancing the ability of natural killer cells to combat hematologic malignancies

A new study reveals a groundbreaking approach to immunotherapy, demonstrating that blocking the interaction between the CD300A receptor and phosphatidylserine (PS) significantly enhances the ability of human natural killer (NK) cells to lyse hematologic malignancies (HMs).

9 May 2024

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

Researchers developed bispecific antibodies targeting both the N-terminal and receptor binding domains of SARS-CoV-2, demonstrating significant neutralization across various Omicron variants, suggesting potential for new COVID-19 treatments.

9 May 2024

Clinical trial shows CRISPR gene editing has exciting potential to treat a rare form of blindness

A recent study published in The New England Journal of Medicine investigated the potential use of gene editing to correct a congenital retinal degeneration called CEP290 that causes early-onset vision loss.

8 May 2024

Mathematical microscope sheds light on efficient memory formation even during sleep

UCLA Health researchers have discovered a mechanism that creates memories while reducing metabolic cost, even during sleep.

8 May 2024

Compound 12: A promising candidate for heart failure therapy with reduced glucose-lowering activity

Prior research showed that thoughtful structural modifications can dissociate the anti-heart failure activity from glucose-lowering effects.

8 May 2024

New family of compounds shows promise as treatment for parasitic worms

An international team led by researchers at the University of Toronto has found a family of natural compounds with potential as new and more effective treatments for parasitic worms.

8 May 2024

APOE4 gene linked to early onset Alzheimer's, target for therapeutic intervention

A study published in Nature Medicine delineates how APOE4 homozygosity distinctly accelerates Alzheimer's disease pathology and biomarkers from the age of 55, suggesting a unique form of the disease and a potential focus for targeted therapies.

8 May 2024

Bacterial fatty acid metabolite identified as key player in immune regulation

Gut microbiota or the population of microbial inhabitants in the intestine, plays a key role in digestion and maintenance of overall health.-

7 May 2024

Sapio Sciences Unveils Enhanced Molecular Biology Toolkit

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From Sapio Sciences 7 May 2024

Neural circuits revealed as key regulators in body's immune response, study finds

A recent study in Nature reveals how specific neural circuits within the body-brain axis regulate immune responses, highlighting potential new therapeutic approaches for immune disorders.

6 May 2024

in vivo News and Research

Novel gene-delivery vehicle shows promise for treating brain disorders

Mechanistic insights into the role of huc-mscs in treating acute liver failure

New PET imaging biomarker Gal-1 predicts tumor responses to immunotherapy

Sleep and anesthesia hinder brain toxin clearance, study reveals

Study proposes a novel therapeutic avenue for tackling EHF-induced cholangiocarcinogenesis

Human cell-based model of thoracic aortic aneurysm offers new opportunities for drug development

Machine learning unveils hidden gender differences in brain structure

New mechanism discovered to weaken pseudomonas aeruginosa virulence

Experimental gene therapy shows promise for treating herpes infections

Drug repurposing breakthrough: varespladib curbs snakebite-induced necrosis

Enhancing the ability of natural killer cells to combat hematologic malignancies

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

Clinical trial shows CRISPR gene editing has exciting potential to treat a rare form of blindness

Mathematical microscope sheds light on efficient memory formation even during sleep

Compound 12: A promising candidate for heart failure therapy with reduced glucose-lowering activity

New family of compounds shows promise as treatment for parasitic worms

APOE4 gene linked to early onset Alzheimer's, target for therapeutic intervention

Bacterial fatty acid metabolite identified as key player in immune regulation

Sapio Sciences Unveils Enhanced Molecular Biology Toolkit

Neural circuits revealed as key regulators in body's immune response, study finds

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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