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miR-205 knockout surprises with enhanced mammary development and cancer insights

New research unveils the paradoxical role of miR-205 in mammary gland development and its potential impact on breast cancer, highlighting the miRNA's complex involvement in stem cell regulation and tumor suppression.

2 Apr 2024

New technique reveals insights into gut cell dynamics during inflammation

Cells within the intestines perform various roles including nutrient absorption, sensing, and maintaining homeostasis.

2 Apr 2024

Dietary vitamin A shows promise in Alzheimer's disease intervention, study finds

Study explored the impact of dietary vitamin A on gut microbiota and intestinal transcriptome, revealing its potential in Alzheimer's disease (AD) pathology and cognitive functions in mice.

28 Mar 2024

New treatment paradigm focuses on reverting cancer cells to normal state

St. Jude Children's Research Hospital scientists reversed an aggressive cancer, reverting malignant cells towards a more normal state. Rhabdoid tumors are an aggressive cancer which is missing a key tumor suppressor protein.

27 Mar 2024

Breakthrough discovery points to potential treatment for rare neurodegenerative disease

Imagine being middle-aged and starting to feel that you are off balance a lot and that you are having a hard time coordinating your movements.

27 Mar 2024

Xenotransplantation model used for studying microglial response to Alzheimer's disease

Microglia are specialized immune cells in the brain. While they normally protect our brains, they can also contribute to neurodegenerative diseases such as Alzheimer's.

27 Mar 2024

Researchers identify new potential target for the treatment of Alzheimer's disease

Researchers at the University of Leeds and Lancaster University in the UK have identified a new potential target for the treatment of Alzheimer's disease – PDE4B.

26 Mar 2024

ANU scientists uncover gene mutation driving psoriasis and psoriatic arthritis

Scientists from The Australian National University (ANU) have discovered a gene mutation is responsible for causing psoriasis – a chronic inflammatory skin disease that causes patients to develop red, scaly and itchy patches across their body.

25 Mar 2024

New compound shows promise as a more effective treatment for schistosomiasis

A newly developed compound is showing promise in animal studies as a more effective treatment for human schistosomiasis, an understudied tropical disease caused by parasitic worms.

25 Mar 2024

Researchers identify mechanism behind COVID-19 related brain fog

Among the many confounding symptoms in patients recovering from a COVID-19 infection are memory loss and difficulty learning.

21 Mar 2024

Scientists shed light on key immune regulators involved in Alzheimer’s and other disorders of lipid-rich tissues

Using novel genetic and genomic tools, researchers at the Icahn School of Medicine at Mount Sinai have shed light on the role of immune cells called macrophages in lipid-rich tissues like the brain, advancing our understanding of Alzheimer's and other diseases.

21 Mar 2024

Lactate's role in driving cancer cachexia uncovered

Study highlights the significant role of lactate in promoting cancer cachexia via activation of the adipose-specific G-protein-coupled receptor 81 (GPR81), suggesting new therapeutic targets for this condition.

20 Mar 2024

Immune cell protein identified as potential target for rare liver cancer treatment

Fibrolamellar carcinoma (FLC) is a rare liver cancer with a poor prognosis if not addressed early with surgery. The disease is caused by a single genetic mutation that creates a fusion protein.

20 Mar 2024

Ketogenic diet delays the early stages of Alzheimer's-related memory loss in mice

A new study from researchers at the University of California, Davis, shows a ketogenic diet significantly delays the early stages of Alzheimer's-related memory loss in mice.

19 Mar 2024

Artichoke's health secret, traditional remedy to modern marvel

Study highlights the artichoke's nutritional benefits and its potential to improve cardiovascular health, exhibit neuroprotective effects, and offer antimicrobial properties, emphasizing its value beyond dietary use.

18 Mar 2024

Mouse models shed light on the effects of metformin use during pregnancy on offspring

With the rise in gestational diabetes and metabolic disorders during pregnancy, metformin is also being prescribed more frequently.

18 Mar 2024

Study unlocks the mystery of neonatal neutropenia in newborns

Compared to adults, newborns are highly susceptible to infections and these infections can cause serious health complications and even death.

15 Mar 2024

How the brain switches between daydreaming and reality

When we daydream, we must be able to snap back to attention at a moment's notice. Researchers at Boston Children's Hospital uncovered how our brains can do things like react to a question when we're daydreaming: firing activity in part of the brain called the dentate gyrus keeps us focused on what's happening in our environment.

13 Mar 2024

Targeting a non-encoding stretch of RNA may shrink pediatric brain tumors in mice

Targeting a non-encoding stretch of RNA may help shrink tumors caused by an aggressive type of brain cancer in children, according to new research in mice reported March 8 in Cell Reports by Johns Hopkins Kimmel Cancer Center investigators.

13 Mar 2024

Limoncella apple polyphenol extract shines in IBD liver damage study

'Limoncella' apple polyphenol extract (LAPE) shows promise in reducing liver and intestinal inflammation in a mouse model of inflammatory bowel disease (IBD), highlighting potential natural treatment pathways

12 Mar 2024

Mouse Model News and Research

miR-205 knockout surprises with enhanced mammary development and cancer insights

New technique reveals insights into gut cell dynamics during inflammation

Dietary vitamin A shows promise in Alzheimer's disease intervention, study finds

New treatment paradigm focuses on reverting cancer cells to normal state

Breakthrough discovery points to potential treatment for rare neurodegenerative disease

Xenotransplantation model used for studying microglial response to Alzheimer's disease

Researchers identify new potential target for the treatment of Alzheimer's disease

ANU scientists uncover gene mutation driving psoriasis and psoriatic arthritis

New compound shows promise as a more effective treatment for schistosomiasis

Researchers identify mechanism behind COVID-19 related brain fog

Scientists shed light on key immune regulators involved in Alzheimer’s and other disorders of lipid-rich tissues

Lactate's role in driving cancer cachexia uncovered

Immune cell protein identified as potential target for rare liver cancer treatment

Ketogenic diet delays the early stages of Alzheimer's-related memory loss in mice

Artichoke's health secret, traditional remedy to modern marvel

Mouse models shed light on the effects of metformin use during pregnancy on offspring

Study unlocks the mystery of neonatal neutropenia in newborns

How the brain switches between daydreaming and reality

Targeting a non-encoding stretch of RNA may shrink pediatric brain tumors in mice

Limoncella apple polyphenol extract shines in IBD liver damage study

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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