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Key protein EPAC1 found to regulate brown fat growth, offering obesity treatment potential

Study reveals that EPAC1 protein plays a crucial role in regulating the growth of brown and beige adipose tissue, offering potential avenues for treating obesity and improving cardiometabolic health.

11 Jan 2024

Glioblastoma tumor cells mimic neurons to evade treatment

Certain cancers are more difficult to treat because they contain cells that are highly skilled at evading drugs or our immune systems by disguising themselves as healthy cells.

11 Jan 2024

Protein linked to neurodegeneration turns out to be crucial for healthy brain function

Researchers have discovered that a protein called phosphorylated α-synuclein, which is associated with several neurodegenerative diseases such as Parkinson's disease and Lewy body dementia, is also involved in the normal processes of how neurons communicate with each other in a healthy brain.

9 Jan 2024

New peptide library paves the way for targeting elusive cancer factor MYC

Researchers developed a second-generation NTB bicyclic peptide library, identifying NT-B2R, a peptide that effectively targets MYC, a key factor in most human cancers, demonstrating its potential in inhibiting MYC transcription activities and cancer cell proliferation.

8 Jan 2024

Long COVID's hidden toll: How does post-exertional malaise affect skeletal muscles?

Study investigates the pathophysiology of post-exertional malaise in long COVID patients, revealing skeletal muscle changes, exercise capacity reduction, metabolic disturbances, and tissue alterations.

8 Jan 2024

Angelica gigas extract emerges as a potential treatment for vascular disease

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in vascular dysfunction."

28 Dec 2023

Cadmium linked to DNA damage and morphological changes caused by particulate matter

Particulate matter causes health problems for those who inhale the fine droplets and particles, but the chemical composition of the mixture matters-;and can vary widely across space and time.

28 Dec 2023

St. Jude researchers reveal structure of Parkinson's-linked proteins

Scientists at St. Jude Children's Research Hospital revealed the complex structure of two Parkinson's disease-related proteins, both of which are implicated in late-onset cases.

21 Dec 2023

New study pinpoints mitochondria as key player in dietary fat-cancer connection

The research study is entitled "The Central Role of Mitochondria in the Relationship between Dietary Lipids and Cancer Progression". It revealed new findings on the factors that influence the development of diseases, such as the particularly interesting relationship between dietary fats and the development of cancer.

20 Dec 2023

Research uncovers potential treatment target for rare, genetic type of epilepsy

Researchers at the Francis Crick Institute, UCL and MSD have identified a potential treatment target for a genetic type of epilepsy.

11 Dec 2023

Osteopontin-c: A key player in mitochondrial biogenesis and cancer metastasis

A new research paper was published in Oncotarget's Volume 14 on December 1, 2023, entitled, "Osteopontin induces mitochondrial biogenesis in deadherent cancer cells."

5 Dec 2023

Researchers evaluate possible mitochondrial factors in Alzheimer's pathogenesis

A group of authors critically evaluated and interpreted the evidence linking mitochondrial dysfunction and metabolic changes to the pathogenesis of Alzheimer's disease (AD).

5 Dec 2023

New insights into sporadic early-onset Alzheimer's disease

Alzheimer's disease (AD), the most prevalent neurodegenerative disease globally, poses a significant threat to human health.

17 Nov 2023

Study sheds new light on key cellular processes involved in Parkinson's disease progression

In a study published in Nature Communications, investigators at Beth Israel Deaconess Medical Center (BIDMC) shed new light on key cellular processes involved in the progression of Parkinson's disease (PD).

15 Nov 2023

Novel cancer immunotherapy compound degrades an enzyme found in cancer cells and T cells

Researchers in Purdue University's College of Pharmacy are leveraging the dual roles played by an enzyme found in both cancer cells and T cells to create a novel cancer immunotherapy compound.

14 Nov 2023

Synthetic melanin nanoparticles boost wound healing and tissue repair in skin

In a recent study published in npj Regenerative Medicine, researchers discuss the ability of melanin nanoparticles to support wound recovery in mice. The effects at histological and gene levels were explored and confirmed on biomimetic models and human skin explants.

5 Nov 2023

Speeding up Alzheimer's research: Progerin turbocharges cellular models for quicker drug screening

The study reveals that introducing progerin, a protein associated with accelerated aging, into cellular models of Alzheimer's Disease (AD) can hasten the development of AD-related traits. This innovative approach offers a more efficient method for studying AD mechanisms, potentially accelerating the discovery of new treatments.

31 Oct 2023

Redefining the battle against Alzheimer's with tau-focused treatments

Researchers explore the potential of tau-targeting therapies in treating Alzheimer's disease, focusing on immunotherapies and strategies to improve their efficacy. The study dives into the complex biology of tau proteins, their modifications, and how they can be targeted to halt the progression of Alzheimer's.

29 Oct 2023

Is sleep apnea the missing link between high blood pressure and Alzheimer's?

Researchers explore the links between non-dipper hypertension, obstructive sleep apnea (OSA), and Alzheimer's disease (AD). They find that OSA may cause non-dipper hypertension, a condition that exacerbates AD symptoms, but also note that treating OSA can mitigate hypertension and potentially slow AD progression.