Metabolome News and Research

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More than 3,000 chemicals or "metabolites" can be detected in urine, say researchers

Researchers at the University of Alberta announced today that they have determined the chemical composition of human urine. The study, which took more than seven years and involved a team of nearly 20 researchers, has revealed that more than 3,000 chemicals or "metabolites" can be detected in urine.

6 Sep 2013

New metabolic biomarkers can detect risk of illnesses in advance

One of the big challenges of biomedicine is understanding the origin of illnesses in order to improve early detection and significantly increase recovery rates, as well as being able to do what CNIO researchers call preventive molecular medicine, which consists of identifying those individuals who have a greater molecular risk of suffering certain pathologies in order to prevent them.

5 Dec 2012

U-M to improve disease diagnosis through metabolic profiling

The University of Michigan Health System has earned a $9.1 million core grant from the National Institutes of Health to improve disease diagnosis through metabolic profiling.

8 Nov 2012

UCSD bioengineers to play a central role in new NIH program to accelerate metabolomics

With a $6 million grant over five years, bioengineers from the University of California, San Diego will play a central role in a new program from the National Institutes of Health (NIH) to accelerate "metabolomics", an emerging field of biomedical research that offers a path to a wealth of information about a person's nutrition, infection, health, disease status and more.

25 Sep 2012

Circadian rhythms control production of metabolites

By analyzing the hundreds of metabolic products present in the liver, researchers with the UC Irvine Center for Epigenetics & Metabolism have discovered that circadian rhythms - our own body clock - greatly control the production of such key building blocks as amino acids, carbohydrates and lipids.

20 Mar 2012

Scientists use metabolomics to discover DMS linked with neuropathic pain

Millions of people worldwide suffer from a type of chronic pain called neuropathic pain, which is triggered by nerve damage. Precisely how this pain persists has been a mystery, and current treatments are largely ineffective. But a team led by scientists from The Scripps Research Institute, using a new approach known as metabolomics, has now discovered a major clue: dimethylsphingosine (DMS), a small-molecule byproduct of cellular membranes in the nervous system.

23 Jan 2012

International conference on polyphenols and health to be held in Sitges

The 5th International Conference on Polyphenols and Health will bring together over 700 researchers from around the world to discuss the latest findings on the polyphenolic components of food and their role in disease prevention and health promotion.

18 Oct 2011

UC San Diego professor receives NIDDK grant to study kidney complications related to diabetes

Kumar Sharma, MD, FAHA, professor of medicine at the University of California, San Diego School of Medicine and director of the Center for Renal Translational Medicine, has received a $5.9 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health, to study kidney complications related to type 1 and type 2 diabetes.

1 Oct 2011

Insight into acrolein-induced acute lung injury

Metabolon, Inc., the leader in metabolomics, biomarker discovery and biochemical analysis, announces the publication of "Integrative Metabolome and Transcriptome Profiling Reveals Discordant Energetic Stress Between Mouse Strains with Differential Sensitivity to Acrolein-Induced Acute Lung Injury" in The Molecular Nutrition and Food Research Journal.

24 Aug 2011

Scientists demonstrate how cigarette smoke produces different 'metabolites' in individuals

Smoke from cigarettes can affect nearly every organ in the body by promoting cell damage and causing inflammation, but no one has understood which smoker is or is not susceptible to disease development.

7 Apr 2011

New discovery in glioma-associated metabolic changes

Metabolon, Inc., the leader in metabolomics, biomarker discovery and analysis, announces the publication of "Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome", in The Proceedings of the National Academy of Sciences.

3 Mar 2011

Harbor BioSciences announces publication of newly discovered anti-inflammatory steroids

Harbor BioSciences, a biopharmaceutical company developing novel therapeutics for the treatment of cancer, metabolic and inflammatory diseases, today announced publication of newly discovered anti-inflammatory steroids naturally present in humans.

2 Feb 2011

Blood 'metabolomics' study uncovers liver, heart, and kidney toxicity in healthy smokers

Examining the blood "metabolomics" profile of smokers immediately after they had a cigarette revealed activation of pathways involved in cell death, inflammation, and other forms of systemic damage, say researchers at Georgetown Lombardi Comprehensive Cancer Center, part of Georgetown University Medical Center.

9 Nov 2010

AB SCIEX and ETH partner to accelerate analysis and improve results for metabolomics

AB SCIEX, a global leader in life science analytical technologies, today announced that it is working with scientists at the ETH Zurich Institute of Molecular Systems Biology as part of the Swiss Systems Biology Program (SystemsX.ch) to accelerate analysis and improve results for metabolomics, which is the scientific study of chemical processes involving metabolites.

21 Jul 2010

Metabolon unveils novel approach to identify patients at preterm delivery risk

Metabolon, Inc., the leader in global metabolism, biomarker discovery and analysis, announces the publication of "Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery", in The Journal of Maternal-Fetal and Neonatal Medicine.

3 Jul 2010

Study pioneers phenotyping of human metabolome

The old excuse, "I am only overweight because of my genes," is suddenly gaining credibility as researchers uncover ever more evidence that the way our bodies digest and process nutrients in the food we eat is different for every person. The budding discipline of metabolomics strives to investigate these differences in a scientific manner.

12 Apr 2010

Scientists provide the first comprehensive picture of minimal cell

What are the bare essentials of life, the indispensable ingredients required to produce a cell that can survive on its own? Can we describe the molecular anatomy of a cell, and understand how an entire organism functions as a system? These are just some of the questions that scientists in a partnership between the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and the Centre de Regulacio Genòmica (CRG) in Barcelona, Spain, set out to address.

28 Nov 2009

Study identifies genetic variants giving rise to differences in metabolism

Common genetic polymorphisms induce major differentiations in the metabolic make-up of the human population, according to a paper published November 28 in the open-access journal PLoS Genetics.

28 Nov 2008

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

Using a combination of enzyme activity and metabolite profiling, we determined that this protein-whose function was previously unknown-serves as a key regulator of a lipid signaling network that contributes to cancer," said Benjamin F. Cravatt, a Scripps Research professor and a member of its Skaggs Institute for Chemical Biology who led the study.

20 Oct 2006

University of Michigan Medical School to study the science of obesity and metabolism

As millions of Americans prepare their New Year’s resolutions to lose weight, eat better or exercise more, the University of Michigan Medical School is launching a new center that may help explain why so many resolutions fail, while others succeed.

29 Dec 2005