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New collaboration to combat river blindness and lymphatic filariasis

Prof. Achim Hoerauf, Director of the Institute of Medical Microbiology, Immunology and Parasitology at the University Hospital Bonn (UKB), and his team have succeeded in collaborating with the Department of Pharmaceutical Technology and Biopharmacy at the University of Bonn and the Helmholtz Center for Infection Research (HZI), to enter into a partnership with the Japanese pharmaceutical company Eisai for the further development of the antibiotic corallopyronin A (CorA) as a treatment for the neglected tropical diseases river blindness and lymphatic filariasis and to raise a large amount of funding.

10 May 2024

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

Researchers developed bispecific antibodies targeting both the N-terminal and receptor binding domains of SARS-CoV-2, demonstrating significant neutralization across various Omicron variants, suggesting potential for new COVID-19 treatments.

9 May 2024

Youth-onset diabetes linked to higher Alzheimer's risk

Young people with diabetes may have a significantly higher risk of developing Alzheimer's disease later in life, according to a new study by researchers in the Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center at the University of Colorado Anschutz Medical Campus.

8 May 2024

APOE4 gene linked to early onset Alzheimer's, target for therapeutic intervention

A study published in Nature Medicine delineates how APOE4 homozygosity distinctly accelerates Alzheimer's disease pathology and biomarkers from the age of 55, suggesting a unique form of the disease and a potential focus for targeted therapies.

8 May 2024

New diagnostic and treatment approach could revolutionize bladder cancer care

A new diagnostic and treatment approach for bladder cancer will undergo a clinical trial in Queensland.

6 May 2024

Innovative nanoparticle breaks blood-brain barrier to target breast cancer and brain metastases

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have developed a nanoparticle that can penetrate the blood-brain barrier.

6 May 2024

Purdue researcher receives $2.4 million NIH grant to combat antimicrobial resistance in lung infections

Qi "Tony" Zhou, a researcher in Purdue University's College of Pharmacy has received a $2.4 million grant from the National Institutes of Health to fight lung infections that have established a resistance to antimicrobial drugs.

6 May 2024

CRISPR gene editing shows promise for treating individuals with a form of inherited blindness

Results from a groundbreaking clinical trial of CRISPR gene editing in 14 individuals with a form of inherited blindness show that the treatment is safe and led to measurable improvements in 11 of the participants treated.

6 May 2024

Durable lymph-node expansion improves vaccine responses against tumors

Each one of us has around 600 lymph nodes (LNs) – small, bean-shaped organs that house various types of blood cells and filter lymph fluid – scattered throughout our bodies.

6 May 2024

Study: Omega-6 fatty acids could reduce the risk of bipolar disorder

Omega-6 fatty acids, commonly found in eggs, poultry, and seafood, could reduce the risk of bipolar disorder, according to a world-first study from the University of South Australia.

6 May 2024

Novel vaccine approach targets AML and other blood cancers

Acute myeloid leukemia (AML) is a type of blood cancer that forms in the soft marrow of the bones, typically attacking cells that would otherwise form the key component of the body's immunodefense system, white blood cells.

3 May 2024

Unlocking glioblastoma's immune suppression mechanism

The Wistar Institute assistant professor Filippo Veglia, Ph.D., and team, have discovered a key mechanism of how glioblastoma -; a serious and often fatal brain cancer -; suppresses the immune system so that the tumor can grow unimpeded by the body's defenses.

3 May 2024

Gyros Protein Technologies introduces Gyrolab Generic Rodent ADA Kit Reagents to support preclinical immunogenicity assessment

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From Gyros Protein Technologies AB 3 May 2024

Inulin fiber exacerbates inflammatory bowel disease, study finds

Inulin, a type of fiber found in certain plant-based foods and fiber supplements, causes inflammation in the gut and exacerbates inflammatory bowel disease in a preclinical model, according to a new study by Weill Cornell Medicine investigators.

2 May 2024

Study reveals how photobiomodulation improves cognitive alterations from chronic stress

Some neurological disorders can be improved through photobiomodulation, a non-invasive technique based on the application of low-intensity light to stimulate altered functions in specific regions of the body.

2 May 2024

Do flavonoids enhance cognitive function?

A recent study in Nutrients links flavonoid intake to improved cognitive function, though findings indicate further research is needed to understand its impact across diverse populations.

2 May 2024

New monoclonal antibody vaccine slashes malaria risk in children

A recent study demonstrates that the monoclonal antibody-based vaccine L9LS is safe for children aged 6 to 10 and significantly reduces the risk of malaria infection and clinical symptoms by 70% and 77%, respectively.

30 Apr 2024

U of T researchers develop new approach for controlling neuron generation in Parkinson's disease

Researchers at the University of Toronto have found a way to better control the preclinical generation of key neurons depleted in Parkinson's disease, pointing toward a new approach for a disease with no cure and few effective treatments.

30 Apr 2024

Genetic propensity to higher arachidonic acid levels linked to lower bipolar disorder risk

A genetic propensity to higher circulating levels of lipids containing arachidonic acid, an omega-6 polyunsaturated fatty acid found in eggs, poultry, and seafood, has been found to be linked with a lower risk for bipolar disorder, according to a new study in Biological Psychiatry, published by Elsevier.

30 Apr 2024

Genetic associations of key genes in breast cancer pathogenesis

Breast cancer remains a significant global health concern, warranting further exploration into its genetic basis and potential therapeutic targets.

29 Apr 2024

Preclinical News and Research

New collaboration to combat river blindness and lymphatic filariasis

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

Youth-onset diabetes linked to higher Alzheimer's risk

APOE4 gene linked to early onset Alzheimer's, target for therapeutic intervention

New diagnostic and treatment approach could revolutionize bladder cancer care

Innovative nanoparticle breaks blood-brain barrier to target breast cancer and brain metastases

Purdue researcher receives $2.4 million NIH grant to combat antimicrobial resistance in lung infections

CRISPR gene editing shows promise for treating individuals with a form of inherited blindness

Durable lymph-node expansion improves vaccine responses against tumors

Study: Omega-6 fatty acids could reduce the risk of bipolar disorder

Novel vaccine approach targets AML and other blood cancers

Unlocking glioblastoma's immune suppression mechanism

Gyros Protein Technologies introduces Gyrolab Generic Rodent ADA Kit Reagents to support preclinical immunogenicity assessment

Inulin fiber exacerbates inflammatory bowel disease, study finds

Study reveals how photobiomodulation improves cognitive alterations from chronic stress

Do flavonoids enhance cognitive function?

New monoclonal antibody vaccine slashes malaria risk in children

U of T researchers develop new approach for controlling neuron generation in Parkinson's disease

Genetic propensity to higher arachidonic acid levels linked to lower bipolar disorder risk

Genetic associations of key genes in breast cancer pathogenesis

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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