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FDA-approved TIVDAK®: Targeting tissue factor in cervical cancer

On April 29th, 2024, the U.S. FDA granted full approval for Seagen Inc.'s TIVDAK® (tisotumab vedotin) targeting tissue factor (TF) for the treatment of patients with recurrent or metastatic cervical cancer who have progressed on or after chemotherapy. This marks a significant advancement in the therapeutic landscape for cervical cancer, highlighting the potential of antibody-drug conjugates (ADCs) in oncology.

10 May 2024

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

Researchers developed bispecific antibodies targeting both the N-terminal and receptor binding domains of SARS-CoV-2, demonstrating significant neutralization across various Omicron variants, suggesting potential for new COVID-19 treatments.

9 May 2024

Compound 12: A promising candidate for heart failure therapy with reduced glucose-lowering activity

Prior research showed that thoughtful structural modifications can dissociate the anti-heart failure activity from glucose-lowering effects.

8 May 2024

New Quartet nanocage vaccine shows promise against coronavirus variants

Researchers have developed a novel vaccination approach using Quartet nanocages that display receptor-binding domains (RBDs) from different sarbecoviruses, showing enhanced immune responses and potential protection against diverse coronavirus strains including SARS-CoV-2 and its variants.

8 May 2024

Analysis reveals composition of counterfeit pills in Rhode Island's illicit drug supply

A new analysis revealed the frequency of potentially lethal substances, such as fentanyl and xylazine, in counterfeit pills that had been circulating in Rhode Island's illicit drug supply.

7 May 2024

UQ's AMTAR hub advances the development of hyper-accurate cancer drugs

A range of hyper accurate cancer drugs is in production at a newly opened research and manufacturing hub at The University of Queensland.

7 May 2024

Amgen plows ahead with costly, highly toxic cancer dosing despite FDA challenge

When doctors began using the drug sotorasib in 2021 with high expectations for its innovative approach to attacking lung cancer, retired medical technician Don Crosslin was an early beneficiary.

7 May 2024

50 years of lifesaving vaccinations: WHO's EPI saves 154 million lives

The World Health Organization’s Expanded Programme on Immunization (EPI) has prevented 154 million deaths since 1974, significantly reducing global infant mortality and contributing 10.2 billion years of healthy life due to vaccinations.

7 May 2024

Purdue researcher receives $2.4 million NIH grant to combat antimicrobial resistance in lung infections

Qi "Tony" Zhou, a researcher in Purdue University's College of Pharmacy has received a $2.4 million grant from the National Institutes of Health to fight lung infections that have established a resistance to antimicrobial drugs.

6 May 2024

Efficient intranasal delivery of agomelatine via micellar encapsulation

Announcing a new publication for Acta Materia Medica journal. Agomelatine (AGO) is an antidepressant with limited clinical application due to its low bioavailability caused by poor water solubility, severe hepatic degradation, and poor intracerebral distribution.

6 May 2024

Janssen-Cilag seeks European approval for guselkumab in ulcerative colitis and Crohn’s disease treatment

Janssen-Cilag International NV, a Johnson & Johnson company, today announced it has submitted applications to the European Medicines Agency (EMA) seeking to expand the Marketing Authorization Application for TREMFYA® (guselkumab) to include the treatment of adult patients with moderately to severely active ulcerative colitis and moderately to severely active Crohn’s disease.

6 May 2024

New influenza vaccine strategies aim to enhance protection with T-cell responses

A recent review highlights the need for innovative influenza vaccines that combine T-cell and antibody responses to enhance protection across multiple strains and seasons.

6 May 2024

Varenicline dosage increase helps persistent smokers quit

For most smokers, quitting on the first attempt is likely to be unsuccessful, but a new study from The University of Texas MD Anderson Cancer Center found patients were more likely to quit if their cessation regimen was altered and doses were increased.

3 May 2024

Rapamycin shows promise in slowing Alzheimer's disease progression linked to seizures

Protein imbalances that increase brain cell excitability may explain why individuals with Alzheimer's disease (AD) who also experience seizures demonstrate more rapid cognitive decline than those who do not experience seizures.

2 May 2024

Nuclera eProtein Discovery system installed at leading academic institutes

Novel platform automates and accelerates protein production, enabling scale-up to mg amount in less than 48 hours.

From Nuclera 2 May 2024

ELRIG UK announces Profs Ijeoma Uchegbu and Marcus Schindler as keynote speakers at Drug Discovery 2024

Drug Discovery 2024: Connecting Minds, Transforming Science, Empowering Community will take place at ExCeL London from 2–3 October.

From ELRIG (UK) Ltd. 2 May 2024

Psilocybin found to be more effective than controls for treating depression symptoms

Psilocybin - the active ingredient in "magic" mushrooms - is a more effective treatment for symptoms of depression than controls, providing further support for its potential as an antidepressant, suggests a study published by The BMJ today.

1 May 2024

Disruption of smoking cessation medicine linked to avoidable deaths

The disruption to the supply of a prescription medicine that helps people stop smoking may have led to thousands fewer people quitting each year in England, which will lead to avoidable deaths in future, suggests a new study led by UCL (University College London) researchers.

30 Apr 2024

UNIGE's synthetic anticoagulant provides reliable alternative to heparin

Anticoagulant treatments are crucial for managing many conditions, such as heart disease, stroke and venous thrombosis.

30 Apr 2024

Psychedelic compound shows promise in stress relief for socially aggressive mice

A study in Neuropharmacology reveals that a single dose of the psychedelic compound (R)-DOI significantly improves stress-coping behaviors and reduces inflammatory markers in mice subjected to social aggression.

30 Apr 2024

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Pharmaceutical News

FDA-approved TIVDAK®: Targeting tissue factor in cervical cancer

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

Compound 12: A promising candidate for heart failure therapy with reduced glucose-lowering activity

New Quartet nanocage vaccine shows promise against coronavirus variants

Analysis reveals composition of counterfeit pills in Rhode Island's illicit drug supply

UQ's AMTAR hub advances the development of hyper-accurate cancer drugs

Amgen plows ahead with costly, highly toxic cancer dosing despite FDA challenge

50 years of lifesaving vaccinations: WHO's EPI saves 154 million lives

Purdue researcher receives $2.4 million NIH grant to combat antimicrobial resistance in lung infections

Efficient intranasal delivery of agomelatine via micellar encapsulation

Janssen-Cilag seeks European approval for guselkumab in ulcerative colitis and Crohn’s disease treatment

New influenza vaccine strategies aim to enhance protection with T-cell responses

Varenicline dosage increase helps persistent smokers quit

Rapamycin shows promise in slowing Alzheimer's disease progression linked to seizures

Nuclera eProtein Discovery system installed at leading academic institutes

ELRIG UK announces Profs Ijeoma Uchegbu and Marcus Schindler as keynote speakers at Drug Discovery 2024

Psilocybin found to be more effective than controls for treating depression symptoms

Disruption of smoking cessation medicine linked to avoidable deaths

UNIGE's synthetic anticoagulant provides reliable alternative to heparin

Psychedelic compound shows promise in stress relief for socially aggressive mice

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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