Initially developed to treat hematological malignancies, CAR-T therapy is currently being expanded to treat solid tumors by employing specialized CAR-T cells that attack specific antigens. Clinical trials are now underway to assess the efficacy of CAR-T cells that target GPC3, FAP, L1CAM, HER2, MSLN, CEACAM5, IL-13RA2, EpCAM, PSMA, and EGFR.
Third-generation HER2 CAR-T cells have been shown in studies to remove glioblastoma cells successfully, and their efficacy can be increased by combining them with PD-1 and CTLA-4 blockade.
Cytokines, such as IL4, TGF-beta, IL-2, IL-7, IL-10, IL-12, and IL-15, have also been linked to the therapeutic effects of CAR-T therapy. Sino Biological offers a wide range of reagents and services to aid in developing CAR-T treatments for solid tumors.
Figure 1. CAR-T recognizes target antigens and kills tumor cells. Image Credit: Sino Biological Inc.
Featured recombinant proteins
Sino Biological provides high-quality recombinant proteins to aid in developing CAR-T treatments for solid tumors.
- High-purity
- Activity-validated
- Low-endotoxin
- Cited by researchers
Human EGFR protein Cat#: 10001-H08H. HPLC verified
Purity: >90% as determined by HPLC. Image Credit: Sino Biological Inc.
Immobilized human EGF protein (Cat#: 10605-H01H) can bind human EGFR protein.
Human IL13RA2 protein Cat#: 10350-H08H-B
Immobilized human IL13 protein (Cat#: 10369-H01H) can bind human IL13RA2 protein. Image Credit: Sino Biological Inc.
Human HER2/ERBB2 protein Cat#: 10004-H08H. HPLC verified
Ability to block anti-HER2 mediated inhibition of BT474 human breast ductal carcinoma cell proliferation. Image Credit: Sino Biological Inc.
Immobilized human HER2/ERBB2 protein can bind Anti-HER2 antibody (Trastuzumab). Image Credit: Sino Biological Inc.
Human GPC3 protein Cat#: 10088-H08H 8 Citations
Immobilized human GPC3 protein can bind to human bFGF/FGF2 protein. Image Credit: Sino Biological Inc.
More recombinant proteins (partial)
Table 1. Source: Sino Biological Inc.
Cat# |
Proteins |
Species |
Expression Host |
Purity |
Activity |
Tag |
10464-H07H
1 Citation |
FAP |
Human |
HEK293 Cells |
≥ 90 % (SEC-HPLC) |
Active |
His |
10464-H07B
1 Citation |
Human |
Baculovirus-Insect Cells |
> 85 % |
|
His |
90879-C07H |
Cynomolgus |
HEK293 Cells |
> 90 % |
|
His |
10088-H02H2
2 Citations |
GPC3 |
Human |
HEK293 Cells |
> 95 % |
Active |
hFc |
50989-M08B |
Mouse |
Baculovirus-Insect Cells |
> 95 % |
Active |
His |
70265-D08H |
Canine |
HEK293 Cells |
≥ 95 % (SEC-HPLC) |
|
His |
10004-H02H
73 Citations |
HER2 |
Human |
HEK293 Cells |
> 90 % |
Active |
hFc |
10004-HCCH-B
19 Citations |
Human |
HEK293 Cells |
> 95 % |
Active |
|
10004-H20B1 |
Human |
Baculovirus-Insect Cells |
> 85 % |
|
His & GST |
50714-M02H
8 Citations |
Mouse |
HEK293 Cells |
> 90 % |
Active |
hFc |
50714-M08H
1 Citation |
Mouse |
HEK293 Cells |
> 95 % |
Active |
His |
70024-D08H |
Canine |
HEK293 Cells |
> 95 % |
Active |
His |
80079-RCCH
3 Citations |
Rat |
HEK293 Cells |
> 92 % |
|
|
90020-K02H
2 Citations |
Rhesus |
HEK293 Cells |
> 90 % |
Active |
hFc |
90020-K08H |
Rhesus |
HEK293 Cells |
> 90 % (SEC-HPLC) |
Active |
His |
10140-H08H
3 Citations |
L1CAM |
Human |
HEK293 Cells |
> 85 % |
|
His |
50835-M02H |
Mouse |
HEK293 Cells |
≥ 95 % (SEC-HPLC) |
|
hFc |
11077-H02H
7 Citations |
CEACAM5 |
Human |
HEK293 Cells |
≥ 95 % (SEC-HPLC) |
|
hFc |
11077-H08H
5 Citations |
Human |
HEK293 Cells |
≥ 95 % (SEC-HPLC) |
|
His |
54867-M02H1 |
Mouse |
HEK293 Cells |
≥ 90 % (SEC-HPLC) |
|
hFc |
90891-C08H |
Cynomolgus |
HEK293 Cells |
≥ 95 % (SEC-HPLC) |
|
His |
13128-H01H-B
1 Citation |
Mesothelin |
Human |
HEK293 Cells |
> 85 % |
|
hFc |
13128-HNCH |
Human |
HEK293 Cells |
≥ 95 % (SEC-HPLC) |
|
|
5A0830-M08H |
Mouse |
HEK293 Cells |
≥ 95 % (SEC-HPLC) |
|
His |
10350-H03H
4 Citations |
IL13RA2 |
Human |
HEK293 Cells |
> 75 % |
Active |
His & hFc |
10350-H08H
1 Citation |
Human |
HEK293 Cells |
> 85 % |
Active |
His |
50061-M03H |
Mouse |
HEK293 Cells |
> 85 % |
Active |
His & hFc |
70079-D02H
1 Citation |
Canine |
HEK293 Cells |
> 95 % |
Active |
hFc |
80204-R02H |
Rat |
HEK293 Cells |
> 90 % |
Active |
hFc |
10694-H02H
8 Citations |
EpCAM |
Human |
HEK293 Cells |
> 95 % |
|
hFc |
10694-H08H
1 Citation |
Human |
HEK293 Cells |
≥ 90 % (SEC-HPLC) |
Active |
His |
50591-M08H
7 Citations |
Mouse |
HEK293 Cells |
> 95 % |
|
His |
90299-CCCH |
Cynomolgus, Rhesus |
HEK293 Cells |
> 85 % |
|
|
15877-H07H
1 Citation |
PSMA |
Human |
HEK293 Cells |
> 95 % |
Active |
His |
50214-M07H |
Mouse |
HEK293 Cells |
> 88 % |
|
His |
10001-H02H
20 Citations |
EGFR |
Human |
HEK293 Cells |
> 85 % (SEC-HPLC) |
Active |
His |
10001-H20B2
11 Citations |
Human |
Baculovirus-Insect Cells |
> 75 % |
Active |
His & GST |
10001-H27H-B |
Human |
HEK293 Cells |
> 95 % (SEC-HPLC) |
Active |
His & AVI |
51091-M08H
2 Citations |
Mouse |
HEK293 Cells |
> 85 % (SEC-HPLC) |
Active |
His |
70026-D08B |
Canine |
Baculovirus-Insect Cells |
> 90 % |
Active |
His |
80100-R08H
2 Citations |
Rat |
HEK293 Cells |
> 98 % |
Active |
His |
90285-C08H |
Cynomolgus |
HEK293 Cells |
> 90 % (SEC-HPLC) |
Active |
His |
90317-K08H |
Rhesus |
HEK293 Cells |
> 85 % |
Active |
His |
Featured antibodies for target antigens
Sino Biological has created a panel of antibodies for cell therapy research in solid tumors, including IHC-P, ELISA, IP, FCM, and WB.
Anti-EpCAM antibody (Cat#: 10694-R028)
- Type: Rabbit MAb
- Ig Type: Rabbit IgG
- Applications: WB, ELISA, IHC-P, FCM, ICC/IF, IP
Immunochemical staining of human EpCAM in human bladder carcinoma. Image Credit: Sino Biological Inc.
Anti-L1CAM antibody (Cat#: 10140-R014)
- Type: Rabbit MAb
- Ig Type: Rabbit IgG
- Applications: ELISA (Det), IHC-P, FCM, ICC/IF
Flow cytometric analysis of human CD171 expression on HeLa cells. Image Credit: Sino Biological Inc.
Anti-EGFR antibody (Cat#: 10001-R021)
- Type: Rabbit MAb
- Ig Type: Rabbit IgG
- Applications: ELISA, ELISA (Det), ICC/IF
Immunofluorescence staining of Human EGFR in A431 cells. Image Credit: Sino Biological Inc.
Anti-CEACAM5 antibody (Cat#: 11077-R327)
- Type: Rabbit MAb
- Ig Type: Rabbit IgG
- Applications: IHC-P
Immunochemical staining of human CEACAM5 in human colon carcinoma. Image Credit: Sino Biological Inc.
More antibodies for target antigens (partial)
Table 2. Source: Sino Biological Inc.
Cat# |
Antigen |
Species |
Clonality |
Ig Type |
Application |
10464-T16 |
FAP |
Human |
Rabbit PAb |
Rabbit IgG |
ELISA |
100393-R024
2 Citations |
GPC3 |
Human |
Rabbit MAb |
Rabbit IgG |
FCM, ICC/IF |
10088-T16 |
Human |
Rabbit PAb |
Rabbit IgG |
ELISA |
10004-R002
7 Citations |
HER2 |
Human |
Rabbit MAb |
Rabbit IgG |
ELISA, IHC-P, ICC/IF |
10004-R002A |
Human |
Rabbit MAb |
Rabbit IgG |
ELISA, IHC-P, FCM, ICC/IF |
10004-T60
1 Citation |
Human |
Rabbit PAb |
Rabbit IgG |
WB, ELISA, IHC-P, IP |
10004-MM01
11 Citations |
Human |
Mouse MAb |
Mouse IgG2a |
ELISA |
10004-MM03
4 Citations |
Human |
Mouse MAb |
Mouse IgG1 |
FCM, ICC/IF |
10004-MM40 |
Human |
Mouse MAb |
Mouse IgG2b |
IHC-P |
10140-R004
1 Citation |
L1CAM |
Human |
Rabbit MAb |
Rabbit IgG |
ELISA |
10140-R014-F |
Human |
Rabbit MAb |
Rabbit IgG |
FCM |
101901-T08 |
Mouse |
Rabbit PAb |
Rabbit IgG |
IHC-P |
10140-MM01
5 Citations |
Human |
Mouse MAb |
Mouse IgG1 |
ELISA |
11077-R061 |
CEACAM5 |
Human |
Rabbit MAb |
Rabbit IgG |
FCM |
11077-RP01
1 Citation |
Human |
Rabbit PAb |
Rabbit IgG |
ELISA |
11077-MM08 |
Human |
Mouse MAb |
Mouse IgG2a |
ELISA, IHC-P |
13128-MM12 |
Mesothelin |
Human |
Mouse MAb |
Mouse IgG1 |
ELISA, IHC-P |
10350-R018-F |
IL13RA2 |
Human |
Rabbit MAb |
Rabbit IgG |
FCM |
10350-T16 |
Human |
Rabbit PAb |
Rabbit IgG |
ELISA |
80204-T24 |
Human |
Rabbit PAb |
Rabbit IgG |
ELISA, IHC-P |
10694-MM05
6 Citations |
EpCAM |
Human |
Mouse MAb |
Mouse IgG1 |
WB |
10694-MM06-F
1 Citation |
Human |
Mouse MAb |
Mouse IgG1 |
FCM |
10694-R028-A |
Human |
Rabbit MAb |
Rabbit IgG |
FCM |
10694-T52 |
Human |
Rabbit PAb |
Rabbit IgG |
WB, ELISA, IP |
50591-R002 |
Mouse |
Rabbit MAb |
Rabbit IgG |
WB, ELISA, IHC-P |
50591-R065 |
Mouse |
Rabbit MAb |
Rabbit IgG |
IHC-P |
15877-T24 |
PSMA |
Human |
Rabbit PAb |
Rabbit IgG |
ELISA, IHC-P |
15877-T26 |
Human |
Rabbit PAb |
Rabbit IgG |
ELISA, IHC-P, ICC/IF |
201427-T10 |
Human |
Rabbit PAb |
Rabbit IgG |
IHC-P, ICC/IF |
10001-R043 |
EGFR |
Human |
Rabbit MAb |
Rabbit IgG |
ELISA, ICC/IF |
10001-RE01-F |
Human |
Rabbit MAb |
Rabbit IgG |
FCM |
10001-REN01 |
Human |
Rabbit MAb |
Rabbit IgG |
Neutralization |
10001-T48 |
Human |
Rabbit PAb |
Rabbit IgG |
WB, ELISA |
10001-T24 |
Human |
Rabbit PAb |
Rabbit IgG |
ELISA, IHC-P |
10001-MM01
1 Citation |
Human |
Mouse MAb |
Mouse IgG2b |
ELISA |
10001-MM08T |
Human |
Mouse MAb |
Mouse IgG1 |
FCM, ICC/IF |
10001-MM11 |
Human |
Mouse MAb |
Mouse IgG1 |
IHC-P |
Cell therapy-related cytokines
- TGF-β
- IL2
- IL4
- IL7
- IL12
- IL15