Clinical Trial News and Research

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Offering screening options boosts colorectal cancer test rates

The rate of colorectal cancer screenings more than doubled when patients were given a choice between which type of screening they wanted-;a take-home kit or colonoscopy-;compared to those who were only offered the colonoscopy, according to new research led by the Perelman School of Medicine at the University of Pennsylvania.

16 May 2024

Text messages with financial rewards boost weight loss in obese men, study finds

Study found that combining behavioral text messages with financial incentives promotes significant weight loss in obese men, while text messages alone do not.

16 May 2024

New therapy shows greater weight loss in mice by targeting brain's appetite center

A groundbreaking paper in Nature describes a promising new therapy for obesity that leads to greater weight loss in mice than existing medications.

16 May 2024

CONVINCE trial reveals the effect of long-term colchicine on recurrent stroke and cardiovascular events

In the international CONVINCE trial, presented today (15 May 2024) at the European Stroke Organisation Conference (ESOC) 2024, anti-inflammatory treatment with long-term colchicine did not reduce rates of recurrent stroke and cardiovascular events in patients with non-cardioembolic stroke in the primary intention-to-treat analysis.

16 May 2024

Clinical trial suggests hypertension self-management strategies may be effective to control blood pressure

The study findings suggest that self-management strategies for hypertension may effectively reduce blood pressure levels over 24 months without increasing healthcare resource utilization or adverse events as compared to usual care.

16 May 2024

Technology alone insufficient for meaningful weight loss in obesity, study shows

A new Northwestern Medicine study shows that technology alone can't replace the human touch to produce meaningful weight loss in obesity treatment.

15 May 2024

More than 20,000 volunteers join effort to accelerate dementia drug development

More than 20,000 volunteers have been recruited to a resource aimed at speeding up the development of much-needed dementia drugs. The cohort will enable scientists in universities and industry to involve healthy individuals in clinical trials to test whether new drugs can slow the decline in various brain functions including memory and delay the onset of dementia.

15 May 2024

Investigational drug shows promise in increasing oxygen uptake for patients with heart condition

People with a common heart condition were able to use significantly more oxygen while exercising after taking an investigational drug in an international clinical trial, according to a study published today in the New England Journal of Medicine.

14 May 2024

Study reveals unintended consequences of antibiotic choice in sepsis treatment

In emergency rooms and intensive care units across the country, clinicians make split-second decisions about which antibiotics to give a patient when a life-threatening infection is suspected.

14 May 2024

Clinical trial in Seattle aims to transform treatment approaches for pediatric IBD

With pediatric inflammatory bowel disease (IBD) diagnoses on the rise globally, a clinical trial in Seattle aims to transform treatment approaches through deep molecular profiling.

14 May 2024

Children can boost vaccination rates by educating their grandparents

Whether a health education intervention offered to Chinese college students will increase severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) booster vaccinations.

14 May 2024

Obesity, metabolic syndrome impact breast cancer subtypes and mortality

In the Women's Health Initiative (WHI) randomized trial, a low-fat diet reduced breast cancer mortality, especially in women with more metabolic syndrome (MetS) components (obesity, high blood pressure, elevated blood sugar, and abnormal cholesterol).

13 May 2024

SHINE trial reveals risks of high blood sugar in post-thrombolysis stroke care

An ambitious, nationwide clinical trial led by UVA Health's Karen Johnston, MD, has provided doctors with long-needed insights into the importance of managing stroke patients' blood sugar after treatment with clot-busting therapy.

13 May 2024

New collaboration to combat river blindness and lymphatic filariasis

Prof. Achim Hoerauf, Director of the Institute of Medical Microbiology, Immunology and Parasitology at the University Hospital Bonn (UKB), and his team have succeeded in collaborating with the Department of Pharmaceutical Technology and Biopharmacy at the University of Bonn and the Helmholtz Center for Infection Research (HZI), to enter into a partnership with the Japanese pharmaceutical company Eisai for the further development of the antibiotic corallopyronin A (CorA) as a treatment for the neglected tropical diseases river blindness and lymphatic filariasis and to raise a large amount of funding.

10 May 2024

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an aggressive type of brain tumor that is fast growing and difficult to treat.

9 May 2024

Study examines association between neighborhood disadvantage and DNA methylation in brain tissue

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "The association between neighborhood deprivation and DNA methylation in an autopsy cohort."

9 May 2024

First-in-class drug could prevent sepsis-related organ failure and death

A new drug could prevent sepsis-related organ failure and death by restoring the health of a patient's blood vessels.

8 May 2024

Brain-computer interface translates ALS patient's brain activity into spoken words

Researchers successfully used a brain-computer interface to synthesize speech directly from brain activity in an ALS patient, achieving 80% word recognition accuracy by listeners, showcasing the interface's potential for aiding communication in severe speech impairments.

8 May 2024

New tool more accurately predicts an individual's 10-year risk of cardiovascular diseases

Collaborative research, led from the University of Oxford and published today in Nature Medicine, has developed a new tool called QR4 that more accurately predicts an individual's 10-year risk of cardiovascular diseases, like heart disease and stroke, particularly identifying high-risk patients that current prediction tools miss.

8 May 2024

Clinical trial shows CRISPR gene editing has exciting potential to treat a rare form of blindness

A recent study published in The New England Journal of Medicine investigated the potential use of gene editing to correct a congenital retinal degeneration called CEP290 that causes early-onset vision loss.

8 May 2024

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Clinical Trial News and Research

Offering screening options boosts colorectal cancer test rates

Text messages with financial rewards boost weight loss in obese men, study finds

New therapy shows greater weight loss in mice by targeting brain's appetite center

CONVINCE trial reveals the effect of long-term colchicine on recurrent stroke and cardiovascular events

Clinical trial suggests hypertension self-management strategies may be effective to control blood pressure

Technology alone insufficient for meaningful weight loss in obesity, study shows

More than 20,000 volunteers join effort to accelerate dementia drug development

Investigational drug shows promise in increasing oxygen uptake for patients with heart condition

Study reveals unintended consequences of antibiotic choice in sepsis treatment

Clinical trial in Seattle aims to transform treatment approaches for pediatric IBD

Children can boost vaccination rates by educating their grandparents

Obesity, metabolic syndrome impact breast cancer subtypes and mortality

SHINE trial reveals risks of high blood sugar in post-thrombolysis stroke care

New collaboration to combat river blindness and lymphatic filariasis

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Study examines association between neighborhood disadvantage and DNA methylation in brain tissue

First-in-class drug could prevent sepsis-related organ failure and death

Brain-computer interface translates ALS patient's brain activity into spoken words

New tool more accurately predicts an individual's 10-year risk of cardiovascular diseases

Clinical trial shows CRISPR gene editing has exciting potential to treat a rare form of blindness

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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