Amyotrophic Lateral Sclerosis News and Research

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Researchers identify nonelectrical cells that transition the brain from plasticity to stability

Researchers exploring the developing central nervous system of fruit flies have identified nonelectrical cells that transition the brain from highly plastic into a less moldable, mature state.

8 Apr 2021

Researchers test novel gene regulation approach to treat brain diseases

Researchers at the DZNE (Germany), at Massachusetts General Hospital (USA) and at the genomic medicine company Sangamo Therapeutics, Inc. tested a novel gene regulation approach to treat brain diseases such as Alzheimer's in laboratory studies.

22 Mar 2021

Researchers unveil a neuroprotective pathway that suppresses ALS

In general, the RAN proteins are more abundant in the cell nucleus, but in patients with Lou Gehrig's disease, they begin to leak out into the cytoplasm, thereby resulting in abnormal concentration differences.

19 Mar 2021

New high-throughput system for testing drug candidates to treat brain diseases

On the basis of a license agreement with the German Center for Neurodegenerative Diseases (DZNE) and the Leibniz Institute of Polymer Research Dresden (IPF), the Dresden-based start-up "Neuron-D GmbH" is developing a high-throughput system for testing drug candidates to treat neurodegenerative diseases.

18 Mar 2021

Newly discovered cellular stress enzyme may be a target for neurodegenerative disease treatments

An enzyme called MARK2 has been identified as a key stress-response switch in cells in a study by researchers at Johns Hopkins Bloomberg School of Public Health.

11 Mar 2021

Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis

Scientists at the Francis Crick Institute and UCL have identified the trigger of a key cellular change in amyotrophic lateral sclerosis (ALS), a type of motor neurons disease.

4 Mar 2021

Researchers identify drug target to fight Parkinson’s and Alzheimer’s disease

Neurodegenerative disorders such as Parkinson's and Alzheimer's disease are in the firing line after researchers identified an attractive therapeutic drug target.

3 Mar 2021

Study demonstrates intricate relationship between Prpf19 and Exoc7 in inherited ataxias

Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph Disease (MJD), describes the most common form of dominantly inherited ataxia in many populations worldwide, including Hong Kong and mainland China.

1 Mar 2021

Study: Heart problems cause disturbed gene activity in the brain's memory center

Heart problems cause disturbed gene activity in the brain's memory center, from which cognitive deficits arise.

27 Feb 2021

Study offers new insights into "Niemann-Pick type C disease"

In the journal Nature Communications, scientists of the German Center for Neurodegenerative Diseases (DZNE) report new findings on the mechanisms of "Niemann-Pick type C disease" (NPC).

24 Feb 2021

Scientists identify new compound that reverses ALS neuron damage

Northwestern University scientists have identified the first compound that eliminates the ongoing degeneration of upper motor neurons that become diseased and are a key contributor to ALS (amyotrophic lateral sclerosis), a swift and fatal neurodegenerative disease that paralyzes its victims.

23 Feb 2021

Researchers discover first evidence of protein folding driven by liquid-liquid phase separation

Scientists have discovered the first evidence of protein folding driven by liquid-liquid phase separation, a phenomenon in which fluids form into microscopic droplets and separate inside cells -- like drops of oil in water.

20 Feb 2021

Researchers measure baseline activity of single neurons

Our brains are complicated webs of billions of neurons, constantly transmitting information across synapses, and this communication underlies our every thought and movement.

18 Feb 2021

Canadian Neuromuscular Disease Registry increases patient access to research, clinical trials

The Canadian Neuromuscular Disease Registry (CNDR) was launched in 2010 to increase efficient patient access to cutting-edge research and clinical trials, to increase understanding of the natural history and epidemiology of neuromuscular disease across Canada, and to facilitate research collaboration.

3 Feb 2021

Amyotrophic Lateral Sclerosis News and Research

Researchers identify nonelectrical cells that transition the brain from plasticity to stability

Researchers test novel gene regulation approach to treat brain diseases

Researchers unveil a neuroprotective pathway that suppresses ALS

New high-throughput system for testing drug candidates to treat brain diseases

Newly discovered cellular stress enzyme may be a target for neurodegenerative disease treatments

Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis

Researchers identify drug target to fight Parkinson’s and Alzheimer’s disease

Study demonstrates intricate relationship between Prpf19 and Exoc7 in inherited ataxias

Study: Heart problems cause disturbed gene activity in the brain's memory center

Study offers new insights into "Niemann-Pick type C disease"

Scientists identify new compound that reverses ALS neuron damage

Researchers discover first evidence of protein folding driven by liquid-liquid phase separation

Researchers measure baseline activity of single neurons

Canadian Neuromuscular Disease Registry increases patient access to research, clinical trials

Researchers use new imaging technique to understand motor deficits in ALS disease

£1.6 million grant awarded to advance development of MND drug candidate

After a decade of lobbying, ALS patients gain faster access to disability payments

ALS study underscores the unique genetics of Maltese population

Researchers identify link between ALS and accumulation of DNA-RNA hybrids in the genome

Additional data demonstrates positive results of pridopidine drug on Total Functional Capacity

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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