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How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors

Researchers investigate the genetic, immunological, and evolutionary factors that determine the vast variability observed in clinical manifestations of COVID-19.

28 Nov 2022

Feline coronavirus-infected domesticated cats found to possess cross-reactive anti-SARS-CoV-2 antibodies

In a recent study, researchers confirmed that feline coronavirus infection induced the production of cross-reactive antibodies against the SARS-CoV-2 receptor-binding domain in domestic cats.

28 Nov 2022

Memory B and T cells responses differ when induced by SARS-CoV-2 infections or booster vaccinations

In a recent study published in The Journal of Immunology, a team of researchers from Japan examined the memory B and T cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein after the booster dose of the coronavirus disease 2019 (COVID-19) messenger ribonucleic acid (mRNA) vaccine BNT162b2.

27 Nov 2022

High-risk stage III-IV melanoma patients treated with pembrolizumab report better quality of life

Patients with high-risk stage III-IV melanoma who received pembrolizumab after their surgery reported a better quality of life than patients who received the previous standard-of-care treatment with either ipilimumab or high-dose interferon.

23 Nov 2022

New York sewer rats are easily infected by SARS-CoV-2, according to new study

Researchers evaluated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure among rats inhabiting New York City (NYC) during the fall of 2021.

23 Nov 2022

Proteomic analysis identifies novel phenotypes associated with COVID-19 severity in circulating immune cells

In a recent study, researchers used proteomic analysis to identify novel immune cell phenotypes associated with severe coronavirus disease 2019 (COVID-19).

22 Nov 2022

SARS-CoV-2 infection and mRNA vaccination prime transcriptionally distinct CD4+ T cell memory landscapes

Researchers reported that SARS-CoV-2 infection and mRNA vaccination induce distinct memory T cells.

21 Nov 2022

How gut microbes influence immune response to SARS-CoV-2

An article published in Critical Reviews in Food Science and Nutrition journal provides an overview of the role of gut microbiota in shaping the host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Nov 2022

COVID-19 carries a much higher risk of epilepsy and seizures than influenza

COVID-19 increases risk of both seizures and epilepsy as compared to influenza infection

17 Nov 2022

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

Researchers presented a functional analysis of the SARS-CoV-2 open reading frame 3c (ORF3c) protein.

17 Nov 2022

SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

Researchers characterized the expression of IFN-1 and IFN-2, ISGs, and NF-κB in the upper respiratory tracts of patients with mild and severe COVID-19, to understand innate immune responses to SARS-CoV-2 infections.

17 Nov 2022

Research sheds light on cardiac pathology mechanisms of COVID-19

Researchers compared cardiac autopsy samples from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive cases with age-matched samples from influenza hemagglutinin 1 neuraminidase 1 (H1N1) cases, non-influenza lymphocytic myocarditis cases, and heart tissue with no inflammation to understand the mechanisms underlying the pathology of the cardiac complications during coronavirus disease 2019 (COVID-19).

15 Nov 2022

Polyphenols in Mediterranean diet may modulate COVID-19 inflammation

Researchers discuss the beneficial role of polyphenolic plant compounds in the Mediterranean diet in the prevention and treatment of COVID-19.

15 Nov 2022

The impact of lung remodeling from prior helminth infection on SARS-CoV-2 disease pathogenesis

A recent study reported that helminth exposure enhances viral clearance and survival of mice challenged with SARS-CoV-2.

15 Nov 2022

New discovery reveals which patients will survive longer after receiving immunotherapy

Patients with head and neck cancer who have more genetic material on chromosome 9 in their cancer cells survive three times longer after receiving immunotherapy than those with less genetic material there, a new study finds.

14 Nov 2022

First placebo-controlled long-term trial of anifrolumab shows positive results in patients with lupus

Type I interferon (IFN) is a powerful immune activator that is present at high levels in the majority of patients with lupus, an autoimmune disease. In Arthritis & Rheumatology, researchers report positive results from the first placebo-controlled long-term trial of anifrolumab-;a human monoclonal antibody that targets the type I IFN receptor-;in patients with lupus.

14 Nov 2022

A knowledgebase of currently known categorized COVID-19 severity variants

In a recent study posted to the medRxiv* preprint server, researchers assessed human genome variants related to the susceptibility and severity of coronavirus disease 2019 (COVID-19).

10 Nov 2022

Experimental therapeutic cancer vaccine leads to significant tumor regression in mice

An experimental therapeutic cancer vaccine induced two distinct and desirable immune system responses that led to significant tumor regression in mice, report investigators from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

10 Nov 2022

The roles of innate and adaptive immunity in Alzheimer’s disease development and progression

Researchers reviewed research advancements showing the significant role both innate and adaptive immune systems play in the pathological course of Alzheimer’s disease.

10 Nov 2022

Researchers demonstrate that neutralizing antibody titers wane over time in ChAdOx1, BNT162b2 and mRNA-1273 vaccinees

Researchers investigated the neutralization antibody titers and the efficacy of the humoral and cellular immunities in individuals vaccinated with three COVID-19 vaccines.

10 Nov 2022

Interferon News and Research

How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors

Feline coronavirus-infected domesticated cats found to possess cross-reactive anti-SARS-CoV-2 antibodies

Memory B and T cells responses differ when induced by SARS-CoV-2 infections or booster vaccinations

High-risk stage III-IV melanoma patients treated with pembrolizumab report better quality of life

New York sewer rats are easily infected by SARS-CoV-2, according to new study

Proteomic analysis identifies novel phenotypes associated with COVID-19 severity in circulating immune cells

SARS-CoV-2 infection and mRNA vaccination prime transcriptionally distinct CD4+ T cell memory landscapes

How gut microbes influence immune response to SARS-CoV-2

COVID-19 carries a much higher risk of epilepsy and seizures than influenza

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

Research sheds light on cardiac pathology mechanisms of COVID-19

Polyphenols in Mediterranean diet may modulate COVID-19 inflammation

The impact of lung remodeling from prior helminth infection on SARS-CoV-2 disease pathogenesis

New discovery reveals which patients will survive longer after receiving immunotherapy

First placebo-controlled long-term trial of anifrolumab shows positive results in patients with lupus

A knowledgebase of currently known categorized COVID-19 severity variants

Experimental therapeutic cancer vaccine leads to significant tumor regression in mice

The roles of innate and adaptive immunity in Alzheimer’s disease development and progression

Researchers demonstrate that neutralizing antibody titers wane over time in ChAdOx1, BNT162b2 and mRNA-1273 vaccinees

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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