Bone Mineral Density News and Research

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Specific precautions must be taken for individuals on longer-term oral glucocorticoid therapy

Millions of people around the world are prescribed glucocorticoids for a wide variety of inflammatory conditions, including, rheumatoid arthritis, asthma and inflammatory bowel diseases. Although they are effective and widely used, one of the potentially serious side effects of these medications is glucocorticoid-induced osteoporosis.

28 Mar 2012

UK researcher receives IOF-Servier Young Investigator Research Grant

The IOF-Servier Young Investigator Research Grant has been awarded to Dr Mark Edwards, clinical research fellow at the MRC Lifecourse Epidemiology Unit at Southhampton General Hospital in the UK.

27 Mar 2012

Combination of everolimus and exemestane reduces spread of cancer in the bone

Results from a phase III clinical trial evaluating a new treatment for breast cancer in post-menopausal women show that the combination of two cancer drugs, everolimus and exemestane, significantly improves bone strength and reduces the chances of cancer spreading (metastasising) in the bone.

23 Mar 2012

Tarsa advances OSTORA NDA filing through $28M Series B financing

Tarsa Therapeutics, Inc. today announced completion of a $28 million Series B equity financing led by new investor Foresite Capital.

17 Mar 2012

Highlights from Journal of the American Academy of Orthopaedic Surgeons

The Spine Patient Outcomes Research Trial (SPORT) is the first comprehensive study to look at the effectiveness of different treatments for low back and leg pain. It was designed to provide data and outcomes to guide doctors and their patients in their treatment choices for three common spinal disorders: intervertebral disk herniation (IDH), degenerative spondylolisthesis (DS), and lumbar spinal stenosis (LSS).

14 Mar 2012

Vitamin E may lead to thinning and weakening of bones: Study

From studies in laboratory animals it was found that the most common form of vitamin E stimulates the generation of bone-degrading cells. Scientists who carried out the research in Japan are now calling for their results to be followed up in humans.

4 Mar 2012

$DXA scan should be done at shorter intervals for women at high risk for fracture$

DXA scan should be done at shorter intervals for women at high risk for fracture

Although a recent study suggests that women with normal results on dual-energy X-ray absorptiometry (DXA) scans at ages 67 and older may wait up to 15 years for a second test, a Viewpoint article published today in the Journal of Bone and Mineral Research (JBMR) cautions that such a lengthy interval is inappropriate for many adults.

2 Mar 2012

Mechanical dose of load through muscle force may slow bone loss in SCI patients

Loss of bone density leads to brittle bones that fracture easily. It is a major complication of spinal cord injury (SCI), which affects about 250,000 Americans every year.

17 Feb 2012

Genzyme announces four-year data from eliglustat tartrate phase 2 trial on Gaucher disease type 1

Genzyme, a Sanofi company, announced today four-year follow-up data from patients enrolled in the phase 2 clinical trial for its investigational oral therapy for Gaucher disease type 1 known as eliglustat tartrate.

8 Feb 2012

Exemestane has negative effect on postmenopausal women's bone health

Exemestane, a drug used in the prevention of breast cancer in postmenopausal women, has a negative effect on bone density and structure in these women, despite calcium and vitamin D supplements.

8 Feb 2012

$Heart failure associated with 30% increase in major fractures$

Heart failure associated with 30% increase in major fractures

Heart failure is associated with a 30 percent increase in major fractures and also identifies a high-risk population that may benefit from increased screening and treatment for osteoporosis, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

3 Feb 2012

Research roundup: 'No individual mandate' scenarios; Breaking down health care expenditures

This paper expands 2011 research examining whether the health law's controversial individual mandate – which requires most people to have health insurance -- will be effective.

21 Jan 2012

Testing for osteoporosis – how often?

A new study shows that many women who get screened for osteoporosis may not need it. It suggests that the current guidelines result in too many unnecessary tests, increasing costs and sometimes spurring unnecessary treatment.

19 Jan 2012

Women aged 67 years with normal bone mineral density may not need screening again for 15 years

The U.S. Preventive Services Task Force and other organizations have recommended that women ages 65 and older be routinely screened for osteoporosis using bone mineral density (BMD) screening. However, how often women should be screened is a topic that remains controversial and undecided, with no definitive scientific evidence to provide guidance.

19 Jan 2012

Gilead Sciences receives FDA approval for Viread to treat pediatric HIV infection

Gilead Sciences, Inc. announced today that the U.S. Food and Drug Administration (FDA) has approved Viread in combination with other antiretroviral agents for the treatment of HIV-1 infection in pediatric patients ages 2-12.

19 Jan 2012

FRAX tool now available as version 3.5 in 18 languages

FRAX, which is available free online at http://www.shef.ac.uk/FRAX/, is being used by an increasing number of physicians around the world - the online version alone is used to calculate 10-year probability of fracture in approximately 2.8 million patients annually, with numbers growing steadily.

17 Jan 2012

$Physician notification system can help prevent further fractures in osteoporotic patients$

Physician notification system can help prevent further fractures in osteoporotic patients

A simple physician notification system can help prevent further fractures in osteoporotic patients who have had already had fractures, according to a study in CMAJ.

20 Dec 2011

BioInvent announces new BI-505 preclinical data on multiple myeloma

BioInvent International AB announced today that new preclinical data has been presented on its BI-505 programme that demonstrates anti-cancer activity in multiple myeloma and beneficial effect on bone density.

12 Dec 2011

Ovary removal in younger women may lead to low-bone mineral density, arthritis

Having both ovaries removed before age 45 is strongly associated with low-bone mineral density and arthritis in later years, according to a new study by Johns Hopkins oncologists and epidemiologists. The analysis covered several thousand women who took part in a U.S. government-sponsored, multiyear national health study, and excluded women whose ovaries were removed due to cancer.

9 Dec 2011

Zoledronic acid increases bone mineral density, reduces recurrence in postmenopausal breast cancer

The addition of zoledronic acid to adjuvant endocrine therapy increased bone mineral density and reduced the risk for disease recurrence among postmenopausal women with early hormone receptor-positive breast cancer, according to new data from the ZO-FAST trial.

8 Dec 2011

Bone Mineral Density News and Research

Specific precautions must be taken for individuals on longer-term oral glucocorticoid therapy

UK researcher receives IOF-Servier Young Investigator Research Grant

Combination of everolimus and exemestane reduces spread of cancer in the bone

Tarsa advances OSTORA NDA filing through $28M Series B financing

Highlights from Journal of the American Academy of Orthopaedic Surgeons

Vitamin E may lead to thinning and weakening of bones: Study

DXA scan should be done at shorter intervals for women at high risk for fracture

Mechanical dose of load through muscle force may slow bone loss in SCI patients

Genzyme announces four-year data from eliglustat tartrate phase 2 trial on Gaucher disease type 1

Exemestane has negative effect on postmenopausal women's bone health

Heart failure associated with 30% increase in major fractures

Research roundup: 'No individual mandate' scenarios; Breaking down health care expenditures

Testing for osteoporosis – how often?

Women aged 67 years with normal bone mineral density may not need screening again for 15 years

Gilead Sciences receives FDA approval for Viread to treat pediatric HIV infection

FRAX tool now available as version 3.5 in 18 languages

Physician notification system can help prevent further fractures in osteoporotic patients

BioInvent announces new BI-505 preclinical data on multiple myeloma

Ovary removal in younger women may lead to low-bone mineral density, arthritis

Zoledronic acid increases bone mineral density, reduces recurrence in postmenopausal breast cancer

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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