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New fluorescent probes improve tumor detection in mice

Building on his Nobel Prize-winning work creating fluorescent proteins that light up the inner workings of cells, a team of researchers led by Howard Hughes Medical Institute investigator Roger Tsien, PhD, professor of pharmacology, chemistry and biochemistry at the University of California, San Diego and the Moores UCSD Cancer Center has developed biological probes that can stick to and light up tumors in mice.

17 Feb 2010

Amgen and Centocor Ortho Biotech Products: FDA approves REMS for Aranesp, EPOGEN and PROCRIT ESAs

Amgen Inc. and Centocor Ortho Biotech Products, L.P., today announced that the U.S. Food and Drug Administration (FDA) has approved the Risk Evaluation and Mitigation Strategy (REMS) for erythropoiesis-stimulating agents (ESAs), which include Aranesp® (darbepoetin alfa), EPOGEN® (Epoetin alfa) and PROCRIT® (Epoetin alfa).

17 Feb 2010

Embera NeuroTherapeutics establishes clinical development partnership for its cocaine dependence program

Embera NeuroTherapeutics, Inc., a specialty pharmaceutical company developing novel treatments for drug dependence, smoking cessation and obesity, announced today that the company has retained Exponential Pharma Ventures LLC to assist in establishing a clinical development partnership for its cocaine dependence program with a fully integrated pharmaceutical company.

17 Feb 2010

Chemists adopt new approach to optimise enzyme for practical applications

Engineers are unlikely to tinker with the cooling system if they want to increase the size of an engine. Yet chemists at the Max Planck Institute for Coal Research have adopted an approach similar to this in their efforts to optimise an enzyme for practical applications. They

16 Feb 2010

Researchers use model organism to test new therapies for retinal degeneration

Research by Johns Hopkins sensory biologists studying fruit flies, has revealed a critical step in fly vision. Humans with problems in this same step suffer retinal dystrophies, which manifest as visual defects ranging from mild visual impairments to complete blindness.

16 Feb 2010

Eat 'heart-healthy' oats to prevent atherosclerosis

Nutritionist Mohsen Meydani, director of the Vascular Biology Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Boston, Mass., led the research on the oat compounds, called avenanthramides. Meydani previously has shown that phenolic antioxidants in oats obstruct the ability of blood cells to stick to artery walls.

16 Feb 2010

Fourth-quarter and full-year 2009 results announced by Vanda Pharmaceuticals

Vanda Pharmaceuticals Inc., a biopharmaceutical company focused on the development and commercialization of clinical-stage products for central nervous system disorders, today announced financial and operational results for the fourth quarter and full year ended December 31, 2009.

16 Feb 2010

Oncolytics Biotech receives U.K. MHRA approval for REOLYSIN combination Phase 3 trial

Oncolytics Biotech Inc. today announced that it has received a letter of approval from the U.K. Medicines and Healthcare products Regulatory Agency (MHRA) to conduct its Phase 3 trial examining REOLYSIN in combination with paclitaxel and carboplatin in patients with platinum-refractory head and neck cancers. This is the same trial that the Company previously reached an agreement on with the U.S. Food and Drug Administration (FDA) under the Special Protocol Assessment (SPA) process.

16 Feb 2010

12 minutes of activity a day is all you need to reclaim maximum health

You're hitting the gym four to five times a week. You're dutifully doing the elliptical trainer or treadmill for an hour at a time. But all those long, boring workouts do nothing to strengthen your heart or slim your waistline. Do enough cardio and aerobics and you'll get old before your time.

16 Feb 2010

When blood sugar levels rise in healthy people, insulin signals cells to increase production: Study

In type 2 diabetes, which is occurring at alarming rates, the hormone insulin does not work effectively to lower blood sugars and patients also do not make enough insulin. These two processes have been widely considered as separate.

16 Feb 2010

TB's mechanism to evade body's immune system identified

Indiana University School of Medicine researchers have identified a mechanism used by the tuberculosis bacterium to evade the body's immune system and have identified a compound that blocks the bacterium's ability to survive in the host, which could lead to new drugs to treat tuberculosis.

16 Feb 2010

Study: sdNVP can lead to HIV treatment failure in women receiving drug to prevent infant infection

A new international study reported in PLoS Medicine confirms that a single dose of nevirapine (sdNVP) can lead to HIV treatment failure in women who receive the drug to prevent transmission of the AIDS virus to their infants. However, the increased risk of failure could only be detected in women who began full HIV treatment within about a year after receiving sdNVP.

16 Feb 2010

SimMan 3G robotic patient helps pharmacy students practice diagnostic skills

A robot that can be programmed to have a range of medical conditions, from heart disease to constipation, is being used by Pharmacy students at the University of Bath to help practise diagnostic skills and treating patients.

16 Feb 2010

Three Dutch life-science sectors announce joint investment to research on personalized medicine

The Netherlands' three Top Institutes for life-science research (the BioMedical Materials program, the Center for Translational Molecular Medicine and Top Institute Pharma) today announced a joint investment of MEUR 28 on innovative research targeted at bringing personalized medicine closer to reality.

16 Feb 2010

Use of non-steroidal anti-inflammatory drugs not associated with risk of squamous cell skin cancer

Contrary to previous hypotheses, the use of non-steroidal anti-inflammatory drugs does not appear associated with risk of squamous cell skin cancer, according to a report posted online today that will appear in the April print issue of Archives of Dermatology, one of the JAMA/Archives journals.

16 Feb 2010

NorTech announces winners of annual Innovation Awards program

NorTech, in partnership with Crain's Cleveland Business, is pleased to announce the winners of its annual Innovation Awards program which honors the achievements of Northeast Ohio's most innovative organizations and leaders.

16 Feb 2010

Researchers discover chemical compound to combat malaria and bacterial diseases

Researchers report that they have discovered - and now know how to exploit - an unusual chemical reaction mechanism that allows malaria parasites and many disease-causing bacteria to survive. The research team, from the University of Illinois, also has developed the first potent inhibitor of this chemical reaction.

16 Feb 2010

Researchers discover new mechanism within human cells that constantly protects against disease

Researchers at Oregon Health & Science University have discovered a new mechanism within human cells that constantly protects us against disease. P. Michael Conn, Ph.D., a researcher at the OHSU Oregon National Primate Research Center directed the work. The findings are reported in the Feb. 15 issue of the journal Proceedings of the National Academy of Sciences.

16 Feb 2010

Structure of 'DNA repair engine' that reverses beneficial effects of chemotherapy deciphered

Cancer Research UK scientists have deciphered the first structure of 'a DNA repair engine' that reverses the beneficial effects of chemotherapy, according to research published in Nature Structural and Molecular Biology* today.

15 Feb 2010

Research findings may open door to new therapeutic strategies for serious health problems

Drugs that target the way cells convert nutrients into energy could offer new approaches to treating a range of conditions including heart attack and stroke. Using a new way to screen for potential drugs, a team led by Massachusetts General Hospital (MGH) researchers has identified several FDA-approved agents, including an over-the-counter anti-nausea drug, that can shift cellular energy metabolism processes in animals.

15 Feb 2010

Drugs News and Research

New fluorescent probes improve tumor detection in mice

Amgen and Centocor Ortho Biotech Products: FDA approves REMS for Aranesp, EPOGEN and PROCRIT ESAs

Embera NeuroTherapeutics establishes clinical development partnership for its cocaine dependence program

Chemists adopt new approach to optimise enzyme for practical applications

Researchers use model organism to test new therapies for retinal degeneration

Eat 'heart-healthy' oats to prevent atherosclerosis

Fourth-quarter and full-year 2009 results announced by Vanda Pharmaceuticals

Oncolytics Biotech receives U.K. MHRA approval for REOLYSIN combination Phase 3 trial

12 minutes of activity a day is all you need to reclaim maximum health

When blood sugar levels rise in healthy people, insulin signals cells to increase production: Study

TB's mechanism to evade body's immune system identified

Study: sdNVP can lead to HIV treatment failure in women receiving drug to prevent infant infection

SimMan 3G robotic patient helps pharmacy students practice diagnostic skills

Three Dutch life-science sectors announce joint investment to research on personalized medicine

Use of non-steroidal anti-inflammatory drugs not associated with risk of squamous cell skin cancer

NorTech announces winners of annual Innovation Awards program

Researchers discover chemical compound to combat malaria and bacterial diseases

Researchers discover new mechanism within human cells that constantly protects against disease

Structure of 'DNA repair engine' that reverses beneficial effects of chemotherapy deciphered

Research findings may open door to new therapeutic strategies for serious health problems

Drug Discovery - Second Edition eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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