Colon News and Research

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Whole-organ genomic survey depicts journey from normal to malignant cell

Whole-organ maps that superimpose genetic information over the terrain of cancerous bladders chart the molecular journey from normal cell to invasive cancer, an international research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports online at the journal Laboratory Investigation.

5 May 2008

New understanding of colon tumor development

Recent work from the Finnish Academy Center of Excellence on Cancer Biology at the University of Helsinki, Finland, has shed light on the mechanisms of colon tumor development and may help to design better treatment for this disease.

5 May 2008

Epidermal growth factor receptor protects cancer cells from starving

A growth factor receptor found abundantly on the surface of cancer cells and long known to fuel cancer growth also protects tumor cells from starvation by a newly identified mechanism, researchers at The University of Texas M. D. Anderson Cancer Center report in the May 5 issue of Cancer Cell.

5 May 2008

AMPK signaling helps explain how cell growth is inhibited when nutrients are low

A team of scientists at the Salk Institute for Biological Studies think they know how many-if not most-living organisms answer this question. They recently showed that when food supplies dwindle, mammals, fruitflies, or frogs probably activate the same ancient cell signaling pathway in order to conserve energy.

24 Apr 2008

Competency in colonoscopy requires experience with 150 cases or more

Researchers from Korea have found that technically efficient screening and diagnostic colonoscopy generally requires experience with 150 cases or more.

23 Apr 2008

Discovery of new cell targets for preventing growth of breast and other tumors

Researchers at the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill have discovered new targets for cancer treatment aimed at blocking a key step in tumor progression.

23 Apr 2008

MacroChem acquires Virium Pharmaceuticals

MacroChem Corporation announced today that on April 18, 2008 it acquired Virium Pharmaceuticals Inc., a non-public, development stage company developing and commercializing novel therapeutics, with a portfolio of clinical stage product candidates focused in oncology, including its next generation nucleoside analogue licensed from the Southern Research Institute.

23 Apr 2008

Cisplatin found to be less effective than standard treatment for patients with anal cancer

When administered before chemoradiation, the common anti-cancer drug cisplatin neither improved disease-free survival nor reduced the number of colostomies needed when compared to the standard treatment for patients with anal canal cancer, according to a study published in the April 23 issue of the JAMA, the Journal of the American Medical Association.

22 Apr 2008

Chemotherapy causes delayed severe neural damage

Cancer treatment with chemotherapeutic agents is often associated with delayed adverse neurological consequences - an occurrence often referred to as "chemobrain" - that may compromise the quality of life of a proportion of cancer survivors.

21 Apr 2008

The limits of observational data in determining outcomes from cancer therapy

Certain biases may exist in observational studies that compare outcomes of different cancer therapies, making the results questionable.

21 Apr 2008

Hypertension all about what you eat and drink

Scientific research on human metabolism based on people from around the world has revealed compounds in urine indicate surprising differences affecting blood pressure.

20 Apr 2008

Inherited cancer gene mutation more common than formerly believed

A gene mutation responsible for the most common form of inherited colon cancer is older and more common than formerly believed, according to a recent study.

17 Apr 2008

New type of drug shrinks primary breast cancer tumours significantly in just six weeks

A drug that targets the cell surface receptors that play an important role in many types of cancer can bring about significant tumour regression in breast cancer after only six weeks of use, a scientist told the 6th European Breast Cancer Conference (EBCC-6) (Thursday 17 April).

17 Apr 2008

Wild Mediterranean plant provides potential anticancer medicines

A group of scientists from the Department of Organic Chemistry and the Biotechnology Institute of the University of Granada have found out that the plant “Dittirichia viscose”, known as elecampe, can be used to obtain inhibitors of neurogenic vasodilatation, a significant progress in migraine and cancer treatments.

17 Apr 2008

An effective colon cancer prevention treatment

Using a combination of a targeted cancer-fighting agent called DFMO and a low dose of an anti-inflammatory drug, UC Irvine researchers have reduced the risk of reoccurring colorectal polyps, an early sign of colon cancer, by as much as 95 percent with fewer toxic side effects.

15 Apr 2008

Stem cell marker controls two key cancer pathways

Researchers at Georgetown University Medical Center have discovered that a gene associated with human breast stem cells can stimulate development of mammary cells by activating two critical cancer pathways.

15 Apr 2008

Women's colon cancer risk perception associated with screening behavior

Women's perception of their cancer risk appears to vary by race and may affect how likely they are to undergo screenings, particularly for colon cancer, according to a report in the April 14 issue of Archives of Internal Medicine.

15 Apr 2008

Cancer prevention

Tapping into a growing body of knowledge about the origins and progression of cancer, researchers are now developing and testing new preventive therapies to stop it in its tracks.

15 Apr 2008

Targeted therapy combo overcomes treatment resistance in liver cancer

Researchers at the University of Pennsylvania School of Medicine and Abramson Cancer Center reported at the annual meeting of the American Association for Cancer Research that combining two targeted therapies overcomes treatment resistance in liver cancer cell lines.

13 Apr 2008

Targeted therapies overcome treatment resistance in liver cancer cell lines

Researchers at the University of Pennsylvania School of Medicine and Abramson Cancer Center reported today at the annual meeting of the American Association for Cancer Research that combining two targeted therapies overcomes treatment resistance in liver cancer cell lines.

13 Apr 2008