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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Improving sensitivity of liquid biopsy using 'loosely stacked' detection layers

By detecting DNA fragments in body fluids like urine, some types of cancer can already be traced in an early stage. But in order to capture them, detection sensitivity has to be improved.

4 Nov 2020

Europe is the main source of COVID-19 spread, shows study

The University of Huddersfield's Archaeogenetics Research Group has mapped out the dispersal of the SARS-CoV-2 coronavirus, responsible for the current worldwide COVID-19 pandemic, putting Europe centre-stage as the main source of the spread.

4 Nov 2020

Rapid generation of divergent synthetic antibodies against SARS-CoV-2 in a cell-free engineering platform

In a groundbreaking bioRxiv paper, a research group from the Massachusetts Institute of Technology (MIT), Harvard University and Howard Hughes Medical Institute in the US engineered antibodies against the receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein by using a novel approach. In doing so, they also identified more than 800 predicted binder families.

3 Nov 2020

UConn researcher identifies genes and regulatory elements critical to heart development

The advent of genome science has given researchers an unprecedented ability to understand the root causes of a host of conditions.

3 Nov 2020

Machine-learning algorithm helps sort out huge amounts of data for protein research

Sorting huge amounts of data is a bottleneck in protein research, a field that is crucial to make use of the gene-editing technology CRISPR and fully understand diseases like cancer, Alzheimer's and Parkinson's

3 Nov 2020

Biomarkers that are predictive of clinical benefit in Trop-2-expressing triple-negative breast cancer

Oncotarget recently published "Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer" which reported that the authors investigated whether Trop-2-expression and homologous recombination repair of SN-38-mediated double-strand DNA breaks play a role in the sensitivity of triple-negative breast cancer to SG.

3 Nov 2020

Researchers identify a novel vulnerability in advanced prostate cancer

Researchers at the University of Bern led an international team that has identified a novel vulnerability in advanced prostate cancer that is no longer responding to hormonal therapy.

3 Nov 2020

Estonian researchers provide clues to control the aggressive nature of SARS-CoV-2

Recent study by Estonian researchers in University of Tartu explains how coronavirus is activated before attacking the cell and what could help to impede that.

2 Nov 2020

New project aims to find the effect of COVID-19 infection on the next generation

So far, 50 Covid-19 patients between 30 and 40 have delivered a sperm sample. Students are next in line. The plan is that participants will return after 12 months for more testing.

2 Nov 2020

5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

Researchers tested 5-amino levulinic acid in vitro in human-derived cells and found it prevents severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Because it is safe and ubiquitous in plants and animals, it could be a potential drug against SARS-CoV-2.

1 Nov 2020

First-of-its-kind synthetic DNA vaccine designed against Powassan virus

Scientists at The Wistar Institute have designed and tested the first-of-its-kind synthetic DNA vaccine against Powassan virus (POWV), targeting portions of the virus envelope protein.

30 Oct 2020

Study identifies new cause of inflammation in people living with HIV

While current antiretroviral treatments for HIV are highly effective, data has shown that people living with HIV appear to experience accelerated aging and have shorter lifespans - by up to five to 10 years - compared to people without HIV.

30 Oct 2020

Study reveals molecular mechanism that increases the invasiveness of radioresistant cancer cells

Scientists have revealed the molecular mechanism regulating the trafficking of lysosomes that increases the invasiveness of radioresistant cancer cells following radiotherapy.

30 Oct 2020

Researchers identify distinct link between autism and brain cell abnormalities

Johns Hopkins Medicine researchers report that new experiments with genetically engineered mice have found clear connections among a range of autism types and abnormalities in brain cells whose chemical output forges platonic (non-sexual) feelings of love and sociability.

30 Oct 2020

Antiviral inhibitor DDX42 shows broad activity against Chikungunya, HIV and SARS-CoV-2

By exploiting type 1 interferon's ability to foster an antagonistic cellular environment for viral replication, a research group from France pinpointed DEAD-box RNA helicase DDX42 as an intrinsic inhibitor of HIV, but also other pathogenic viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Chikungunya virus.

29 Oct 2020

Tumor suppressor gene represses 'jumping genes'

About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now, UT Southwestern scientists have discovered a new role for p53 in its fight against tumors: preventing retrotransposons, or "jumping genes," from hopping around the human genome.

29 Oct 2020

Severe ulcerative colitis linked to a newly-discovered strain of oral bacteria

Bacteria from the mouth could hold clues to understanding – and potentially treating – severe ulcerative colitis, a painful bowel disease.

29 Oct 2020

Study sheds new light on cell division fidelity, can impact future regenerative medicine

Researchers discover that a specialized part of the chromosomes, essential for a correct cell division, is smaller and weaker in stem cells, when compared to the ones of differentiated cells.

29 Oct 2020

High dose radiation therapy linked to shorter survival times in NSCLC patients

A genetic analysis of non-small cell lung cancer (NSCLC) patients on the phase III NRG Oncology RTOG 0617 clinical trial assessing radiation dose discovered that high dose radiation therapy is associated with shorter survival times among patients with a radiation-sensitive genotype in DNA repair pathway.

29 Oct 2020

Cell biologists and bioimaging expert team up to solve fourth dimension secrets

Cell biologists at the University of Illinois at Urbana-Champaign and Bar-Ilan University at Israel and a bioimaging expert at the University of Central Florida are teaming up in what they hope may lead to a major breakthrough in understanding of the three-dimensional organization of the nucleus over time and their role in certain diseases.

29 Oct 2020

DNA News and Research

Further Reading

Improving sensitivity of liquid biopsy using 'loosely stacked' detection layers

Europe is the main source of COVID-19 spread, shows study

Rapid generation of divergent synthetic antibodies against SARS-CoV-2 in a cell-free engineering platform

UConn researcher identifies genes and regulatory elements critical to heart development

Machine-learning algorithm helps sort out huge amounts of data for protein research

Biomarkers that are predictive of clinical benefit in Trop-2-expressing triple-negative breast cancer

Researchers identify a novel vulnerability in advanced prostate cancer

Estonian researchers provide clues to control the aggressive nature of SARS-CoV-2

New project aims to find the effect of COVID-19 infection on the next generation

5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

First-of-its-kind synthetic DNA vaccine designed against Powassan virus

Study identifies new cause of inflammation in people living with HIV

Study reveals molecular mechanism that increases the invasiveness of radioresistant cancer cells

Researchers identify distinct link between autism and brain cell abnormalities

Antiviral inhibitor DDX42 shows broad activity against Chikungunya, HIV and SARS-CoV-2

Tumor suppressor gene represses 'jumping genes'

Severe ulcerative colitis linked to a newly-discovered strain of oral bacteria

Study sheds new light on cell division fidelity, can impact future regenerative medicine

High dose radiation therapy linked to shorter survival times in NSCLC patients

Cell biologists and bioimaging expert team up to solve fourth dimension secrets

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