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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Researchers apply CRISPR technology to eliminate fusion genes present in tumor cells

The CRISPR/Cas9 gene-editing tool is one of the most promising approaches to advancing treatments of genetic diseases - including cancer -, an area of research where progress is constantly being made.

9 Oct 2020

Excess genetic exchanges impede the segregation of chromosomes into eggs

The exchange of DNA between chromosomes during the early formation of sperm and egg cells normally is limited to assure fertility.

8 Oct 2020

Virginia Tech to build a cyberinfrastructure for wastewater antibiotic-resistant gene monitoring

Antibiotic resistance is a grand challenge of the 21st century. According to the U.S. Centers for Disease Control and Prevention, antibiotic resistance rates are increasing globally, with an estimated 35,000 related deaths per year in the United States in 2019, compared to 23,000 in 2013.

8 Oct 2020

Using mRNA therapies or CRISPR gene editing to treat cystic fibrosis

The potential for treating cystic fibrosis (CF) using mRNA therapies or CRISPR gene editing is possible regardless of the causative mutation. CF clinical trials showing that a genotype-agnostic gene therapy for CF is possible are reviewed in the peer-reviewed journal Human Gene Therapy.

8 Oct 2020

Detection of SARS-CoV-2 viral persistence in built environments

In a recent paper in an open-access journal, mSystems, published by The American Society for Microbiology, Ceth W. Parker et al. show challenges in recovering the virus, change in infectivity, and the case of viral persistence in built environments.

8 Oct 2020

Exome sequencing sheds light on genetic causes of nonimmune hydrops fetalis

A new study by University of California researchers shows the promise of high-throughput DNA-sequencing technologies to improve prenatal diagnosis and pregnancy outcomes for women who have experienced an abnormal prenatal ultrasound.

8 Oct 2020

Researchers discover a principle that explains metastasizing of prostate cancer

An international research team has discovered a principle that explains the metastasizing of prostate cancer.

8 Oct 2020

PCR Biosystems launches NGSBIO Library Quant Kit for Illumina

PCR Biosystems, the UK-based PCR experts, have expanded their range of specialist molecular biology kits with the introduction of NGSBIO Library Quant Kit for Illumina®.

From PCR Biosystems Ltd. 8 Oct 2020

UC Davis School of Medicine and UTHealth receive NIH grant for dementia research

A team of brain scientists from UC Davis School of Medicine and The University of Texas Health Science Center at Houston has been awarded a six-year grant expected to total $53.6 million from the National Institutes of Health.

7 Oct 2020

Rare gene mutations can cause cerebral palsy, confirms new study

An international research team including the University of Adelaide has found further evidence that rare gene mutations can cause cerebral palsy, findings which could lead to earlier diagnosis and new treatments for this devastating movement disorder.

7 Oct 2020

Case report of arthritis in a COVID-19 patient

The current paper published in the The Lancet Rheumatology discusses arthritis in a 58-year-old white woman with COVID-19 of less than severe intensity.

7 Oct 2020

Study: Leukocyte telomere length may offer key insights into woman's longevity

No one knows for sure how long they will live. A new study, however, suggests that leukocyte telomere length may offer some key insights into a woman's longevity and further demonstrates how maternal age at birth of last child affects telomere length and long-term health.

7 Oct 2020

Study determines frequency and patterns of T-cell escape mutations in HIV patients undergoing antiretroviral therapy

Immune cells that can recognize residual HIV-infected cells in people living with HIV (PLWH) who take antiretroviral therapy (ART) remain active for years, says a new study published today in eLife.

7 Oct 2020

Researchers decipher evolution of the Y chromosome in great apes

New analysis of the DNA sequence of the male-specific Y chromosomes from all living species of the great ape family helps to clarify our understanding of how this enigmatic chromosome evolved.

6 Oct 2020

Sperm mitochondrial DNA biomarkers may predict male reproductive health and pregnancy success

Researchers at the University of Massachusetts Amherst have identified a single-measure biomarker in sperm mitochondrial DNA that may predict male reproductive health and pregnancy success.

6 Oct 2020

'Dipstick' technology could be used for mobile and accurate COVID-19 testing

Technology that helps to quickly extract and analyze genetic material could be used for cheap, accurate and mobile COVID-19 testing, including at airports and remote testing centres.

6 Oct 2020

Cancer mutations are found in distinct regions that vary based on genomic structure and mutation

A new study from researchers at The University of Texas MD Anderson Cancer Center has discovered that mutations found in cancers do not accumulate randomly, but are found in distinct patterns that vary based on the three-dimensional organization of the genome in the cell as well as the underlying factors causing the mutations

6 Oct 2020

CAR T cell therapy can predict treatment response in patients with large B-cell lymphoma

Researchers at The University of Texas MD Anderson Cancer Center have identified molecular and cellular characteristics of anti-CD19 CAR T cell infusion products associated with how patients with large B-cell lymphoma (LBCL) respond to treatment and develop side effects.

6 Oct 2020

Researchers discover a new, rapid method to fabricate nanoparticles

Northwestern University researchers are casting a net for nanoparticles.The team has discovered a new, rapid method for fabricating nanoparticles from a simple, self-assembling polymer.

6 Oct 2020

Thiopurines could help stop viral replication in human coronaviruses

Researchers from the Department of Microbiology & Immunology, Dalhousie University, University of Calgary, and Department of Biochemistry and Molecular Biology, University of British Columbia, Canada, worked with human coronaviruses in cell cultures to look for drugs that might prevent accumulation and replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

6 Oct 2020