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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Simple blood tests can benefit women with breast cancer

A blood test that can identify a variety of mutations in advanced breast cancer can reliably match women to effective targeted treatments, early results of a major clinical trial reveal.

11 Sep 2020

New book gives overview of viruses and how they emerge to cause pandemics

Since the novel coronavirus SARS-Cov-2 emerged late last year, it has been virtually impossible to consume any news without encountering stories about the virus and how it spreads, potential treatments, and the development of new vaccines.

11 Sep 2020

Effective, simple, safe self-amplifying RNA vaccines

A recent review paper in the journal Current Opinion in Virology in September 2020 shows how a new generation of RNA vaccines called self-amplifying RNA vaccines are more potent than conventional mRNA vaccines and could hold the key to the global production of cost-effective potent COVID-19 vaccines.

11 Sep 2020

Study sheds light on how interferon-gamma drives response to immunotherapy in melanoma

A new study by researchers at the UCLA Jonsson Comprehensive Cancer Center sheds light on how interferon-gamma (IFN-y), an immune response-stimulating signaling molecule that helps activate immune cells, guides the treatment response in people with advanced melanoma who are treated with one of the leading immunotherapies -; immune checkpoint blockade.

10 Sep 2020

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Researchers designed DLnano-vaccines displaying 60 copies of protein parts derived from the melanoma-specific antigens Trp2 and Gp100 and tested these in mouse models of melanoma, observing prolonged survival that depended on CD8 T cell activation both in therapeutic and prophylactic settings.

10 Sep 2020

Early epigenetic changes can be detected in patients before the diagnosis of diabetes

Epigenetic changes in the islets of Langerhans of the pancreas can be detected in patients several years before the diagnosis of type 2 diabetes (T2D).

10 Sep 2020

Gestational diabetes may have long-term effects on epigenetic aging in offspring

Children born to mothers who had diabetes during pregnancy may age faster biologically and be at an increased risk for obesity and high blood pressure, according to Rutgers researchers.

10 Sep 2020

Scientists claim serious data discrepancies in RaTG13 sequence

Even as the COVID-19 pandemic enters its ninth month, scientists continue to debate the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) intensely. A new preprint published in September 2020 discusses the current issues with the bat coronavirus (CoV) strain that is often considered to have very close homology with the above-mentioned virus, concluding that there are inadequate grounds to consider it to be the ancestral pool of SARS-CoV-2.

10 Sep 2020

PCR Biosystems introduces RiboShield RNase Inhibitor for use in RNA-sensitive applications

PCR Biosystems has today launched RiboShield RNase Inhibitor. Already an important component of several PCR Biosystems kits, this robust and reliable RNase inhibitor is, for the first time, available as a standalone product.

From PCR Biosystems Ltd. 10 Sep 2020

Researchers identify DNA activation code using artificial intelligence

Scientists have long known that human genes spring into action through instructions delivered by the precise order of our DNA, directed by the four different types of individual links, or "bases," coded A, C, G and T.

10 Sep 2020

New method could advance efforts to find drugs that kill breast cancer cells

Scientists at Johns Hopkins Medicine and the University of Oxford say they have found a new way to kill some multiplying human breast cancer cells by selectively attacking the core of their cell division machinery.

10 Sep 2020

Fungi can develop drug resistance without genetic changes

The management of fungal infections in plants and humans could be transformed by a breakthrough in understanding how fungi develop resistance to drugs.

9 Sep 2020

Researchers discover a new way to limit inflammation from adjuvants in vaccines

Adjuvants are a key ingredient of many modern vaccines, working to unleash an immune response that helps protect the body from disease. Many scientists believe that adjuvants are they key to developing new kinds of vaccines for hard-to-vaccinate viruses, like HIV.

9 Sep 2020

Study sheds new light on function and regulation of APOBEC3B in adrenocortical carcinoma

The cover for issue 36 of Oncotarget features, "Knockdown of APOBEC3B is associated with a lower tumor growth in an adrenocortical carcinoma xenograft mouse model," by Gara, et al. which reported that the role of APOBEC3B in adrenocortical carcinoma and the mechanisms through which its expression is regulated in cancer are not fully understood.

9 Sep 2020

New project seeks to understand the origin and role of ecDNA in cancer development

A team of pediatric oncologists led by PD Dr. Anton G. Henssen has set out to further improve our understanding of the mechanisms involved in cancer development and disease progression.

8 Sep 2020

Six genomics research projects receive grants to address the role of ethnicity in major cancers

Leading cancer scientists working with the New York Genome Center (NYGC) announced today that grants are being awarded to fund six projects that address the role of ethnicity in several major cancer types, taking advantage of the diversity of patients being treated at health care institutions throughout the New York City area.

8 Sep 2020

Acne drug could be a potential treatment for dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, affecting 1 in 250 people. The disease is characterised by an increase in size of the left ventricle of the heart.

8 Sep 2020

Personalized determination of genetic factors may improve treatment for polycythaemia vera

Polycythaemia vera is a chronic malignant disease of the haematopoietic system and is treated with interferon-alpha-based drugs, in most cases with long-lasting success. However, in some cases this therapy is unsuccessful for reasons that are not yet understood.

8 Sep 2020

Study links brain astrocyte dysfunction to Parkinson’s disease pathology

A new study using induced pluripotent stem cell technology links astrocyte dysfunction to Parkinson’s disease pathology.

8 Sep 2020

PI3K/mTOR and topoisomerase inhibitors suggested as candidates to reduce expression of ACE2

A recent study published in the preprint server medRxiv in September 2020 shows that the already approved drug families called P13K/mTOR and topoisomerase inhibitors may be useful in reducing individual susceptibility to the virus.

7 Sep 2020

DNA News and Research

Further Reading

Simple blood tests can benefit women with breast cancer

New book gives overview of viruses and how they emerge to cause pandemics

Effective, simple, safe self-amplifying RNA vaccines

Study sheds light on how interferon-gamma drives response to immunotherapy in melanoma

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Early epigenetic changes can be detected in patients before the diagnosis of diabetes

Gestational diabetes may have long-term effects on epigenetic aging in offspring

Scientists claim serious data discrepancies in RaTG13 sequence

PCR Biosystems introduces RiboShield RNase Inhibitor for use in RNA-sensitive applications

Researchers identify DNA activation code using artificial intelligence

New method could advance efforts to find drugs that kill breast cancer cells

Fungi can develop drug resistance without genetic changes

Researchers discover a new way to limit inflammation from adjuvants in vaccines

Study sheds new light on function and regulation of APOBEC3B in adrenocortical carcinoma

New project seeks to understand the origin and role of ecDNA in cancer development

Six genomics research projects receive grants to address the role of ethnicity in major cancers

Acne drug could be a potential treatment for dilated cardiomyopathy

Personalized determination of genetic factors may improve treatment for polycythaemia vera

Study links brain astrocyte dysfunction to Parkinson’s disease pathology

PI3K/mTOR and topoisomerase inhibitors suggested as candidates to reduce expression of ACE2

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