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New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Oncotarget published "Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells" which reported that to ascertain phenotypical differences between these two distinct culture conditions, these authors carried out a comparative proteomic analysis of a membrane fraction obtained from 3D- and 2D-cultured NSCLC model cell line NCI-H23.

29 Sep 2021

Combination of two drugs may help pancreatic and liver cancer patients

A drug candidate discovered and developed decades ago in the laboratory of UC Davis distinguished professor Bruce Hammock may help control the body's raging and often deadly inflammatory response to chemotherapy treatments, especially for pancreatic and liver cancer patients.

29 Sep 2021

Stringent lineage tracing is vital for nerve cell regeneration studies

UT Southwestern stem cell scientists find that stringent lineage tracing is crucial for studies of nerve cell regeneration. Their results, which are published in Cell, show that this tracing is far from routine in the field and suggest that earlier studies reporting "striking" regeneration results must be reexamined.

29 Sep 2021

Exposure to smoking and mutations in blood cells may lead to a rare cancer that affects immune cells

Mutations in blood cells likely caused by smoking and aging-related changes may lead to a rare type of blood cancer that affects immune cells, shows a study published today in eLife.

28 Sep 2021

Clinical study tests novel topical corneal epithelial stem cell-derived product for treating dry eye disease

Several studies conducted over the last decade have concluded that dry eye disease (DED) affects up to 50% of the U.S. population, creating a liability for the nation's health care system that is estimated to exceed $50 billion annually.

28 Sep 2021

Study shows Delta variant is main variant causing vaccine breakthrough COVID-19 infections, irrespective of manufacturer

In a recent study, researchers from Texas assessed the incidence of new SARS-CoV-2 variants of concern in the communities in Dallas-Fort Worth (DFW).

28 Sep 2021

Southeast Asia - A hotspot of many viruses with potential to cause pandemics

A new study reveals that scientists have found three viruses in bats in Laos that exhibit similar characteristic features as SARS-CoV-2.

28 Sep 2021

Machine learning may predict zoonotic potential of viral genomes

Most emerging infectious diseases of humans (like COVID-19) are zoonotic – caused by viruses originating from other animal species. Identifying high-risk viruses earlier can improve research and surveillance priorities.

28 Sep 2021

BostonGene and MD Anderson collaborate to advance the development of multiplatform biomarker signatures

The University of Texas MD Anderson Cancer Center and BostonGene Corporation today announced a strategic alliance to advance the development and clinical integration of multiplatform biomarker signatures.

28 Sep 2021

Mass Eye and Ear researcher receives P50 NIH grant to establish new center for neurological voice disorders

Kristina Simonyan, MD, PhD, Dr med, director of laryngology research at Mass Eye and Ear, has been awarded an $11.9 million P50 Clinical Research Center Grant from the National Institute on Deafness and Other Communicable Disorders of the National Institute of Health to form a new multidisciplinary center across four academic medical institutions that will be committed to conducting research on laryngeal dystonia and voice tremor, two debilitating neurological voice disorders.

28 Sep 2021

Southampton researchers invent new way to generate cartilage tissue from stem cells

Researchers at the University of Southampton have invented a new way to generate human cartilage tissue from stem cells. The technique could pave the way for the development of a much-needed new treatment for people with cartilage damage.

28 Sep 2021

Researchers develop efficient approach to identify 3D features of post-infarction scarring

A multidisciplinary team of scientists based at the Universidad de Valladolid and the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has developed a highly efficient method for identifying the 3-dimensional features of the scar tissue formed after a myocardial infarction.

28 Sep 2021

Hamilton and Rhinostics Reinvent Rapid Swab-Based Sample Workflows from Collection to Processing

Hamilton Company and Rhinostics are combining their respective strengths to improve the speed and quality of nasal and nasopharyngeal sample workflows.

From Hamilton Company 28 Sep 2021

Evidence of persisting autoreactivity in post-acute sequelae of SARS-CoV-2 infection?

It has been demonstrated in recent studies that there is a significant breadth of emerging autoreactivity associated with severe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. More specifically, researchers from Emory University have identified a relaxation of peripheral tolerance within early antibody secretion cells that arise in individuals infected with SARS-CoV-2, as important drivers of those responses.

28 Sep 2021

Researchers release guidance to address pathology aspects in clinical trial protocols

An international group of cancer researchers, led by the National Cancer Research Institute's (NCRI) Cellular Molecular Pathology Initiative (CMPath), has published guidance to address the variability in how pathology is planned and delivered in clinical trials.

28 Sep 2021

Study maps hotspots of low-value care use at individual health systems

Researchers estimate that up to $101 billion in health care spending is wasted each year due to over-treatment or the delivery of "low-value care." Low-value care includes a wide array of tests and treatments that are medically unnecessary and for which the potential for harm outweigh the potential for benefit. While researchers have charted the ongoing use of low-value care on national and regional levels, little research exists on how health systems across the country use low-value care and how they compare to each other.

28 Sep 2021

New discovery greatly improves detection of HPV in the bloodstream

Princess Margaret Cancer Centre researchers have made new findings which greatly improve detection of the human papillomavirus (HPV) in the bloodstream and could further hone precision treatment of the illness.

27 Sep 2021

Drug treatment decreases risk for severe COVID-19 outcomes in patients with Type 2 diabetes

A type of drug already used to treat obesity and Type 2 diabetes, when taken six months prior to the diagnosis of COVID-19, was associated with a decreased risk of hospitalization, respiratory complications and death in COVID-19 patients with Type 2 diabetes, according to researchers at Penn State College of Medicine.

27 Sep 2021

Researchers investigate dynamic changes in mosquitoes and their viromes in Wuhan during 2020

Announcing a new article publication for Zoonoses journal. Researchers from Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China, Jinan University, Shenzhen, China and Shanghai Jiao Tong University School of Medicine, Shanghai, China consider dynamic surveillance of mosquitoes and their viromes in Wuhan during 2020.

27 Sep 2021

An in-depth assessment into origin and spread of SARS-CoV-2 Delta variant in Brazil

Brazilian researchers characterize the dissemination of the Delta VOC in Brazil and assess its emergence within the global Delta phylogeny.

27 Sep 2021

Laboratory News and Research

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Combination of two drugs may help pancreatic and liver cancer patients

Stringent lineage tracing is vital for nerve cell regeneration studies

Exposure to smoking and mutations in blood cells may lead to a rare cancer that affects immune cells

Clinical study tests novel topical corneal epithelial stem cell-derived product for treating dry eye disease

Study shows Delta variant is main variant causing vaccine breakthrough COVID-19 infections, irrespective of manufacturer

Southeast Asia - A hotspot of many viruses with potential to cause pandemics

Machine learning may predict zoonotic potential of viral genomes

BostonGene and MD Anderson collaborate to advance the development of multiplatform biomarker signatures

Mass Eye and Ear researcher receives P50 NIH grant to establish new center for neurological voice disorders

Southampton researchers invent new way to generate cartilage tissue from stem cells

Researchers develop efficient approach to identify 3D features of post-infarction scarring

Hamilton and Rhinostics Reinvent Rapid Swab-Based Sample Workflows from Collection to Processing

Evidence of persisting autoreactivity in post-acute sequelae of SARS-CoV-2 infection?

Researchers release guidance to address pathology aspects in clinical trial protocols

Study maps hotspots of low-value care use at individual health systems

New discovery greatly improves detection of HPV in the bloodstream

Drug treatment decreases risk for severe COVID-19 outcomes in patients with Type 2 diabetes

Researchers investigate dynamic changes in mosquitoes and their viromes in Wuhan during 2020

An in-depth assessment into origin and spread of SARS-CoV-2 Delta variant in Brazil

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