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CAR T cells expressing a natural RNA can activate the body’s own T cells against solid tumors

Chimeric antigen receptor (CAR) T cell therapy, which uses engineered T cells to treat certain types of cancers, has often been a challenging approach to treating solid tumors. CAR T cells need to recognize a specific target on cancer cells to kill them.

2 Sep 2021

Research uncovers test to identify iMCD patients with superior response to FDA-approved treatment

New research has uncovered a precision medicine test using blood proteins to identify a novel patient subgroup of idiopathic multicentric Castleman disease (iMCD), a rare blood disorder, who are more likely to respond to siltuximab, the only FDA approved treatment for the disease.

2 Sep 2021

World renowned immunologist named chief of Feinberg's Division of Allergy and Immunology

Stephanie Eisenbarth, MD, PhD, has been named chief of Feinberg's Division of Allergy and Immunology in the Department of Medicine, and director of the newly formed Center for Human Immunobiology.

2 Sep 2021

Risk of COVID-19 transmission from animals to older adults

A new study in the journal GeroScience deals with this aspect of the disease, especially with respect to preventing higher death rates in older adults.

2 Sep 2021

Booster shot of Pfizer COVID-19 vaccine provides additional protection against SARS-CoV-2 infection

A team of scientists from the USA and Israel has recently highlighted the importance of a third booster dose of the Pfizer/BioNTech coronavirus disease 2019 (COVID-19) vaccine in achieving additional protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study is currently available on the medRxiv* preprint server.

2 Sep 2021

Research investigates how drug-eluting stent affects arterial tissue permeability and blood flow

For patients with symptomatic coronary artery disease, the best course of action often involves implanting a drug-eluting stent into the artery where a plaque buildup is blocking blood flow to the heart.

2 Sep 2021

Study identifies how immune sensors launch a multi-faceted innate immune response to infections

St. Jude Children's Research Hospital immunologists have identified how immune sensors in infected cells organize and launch a multi-faceted innate immune response to infections with live viruses and bacteria. The discovery appears today in Nature.

2 Sep 2021

Study suggests a biological basis behind instantaneous compatibility reaction

Have you ever met someone you instantly liked, or at other times, someone who you knew immediately that you did not want to be friends with, although you did not know why?

2 Sep 2021

First-of-its-kind bionic arm restores natural behaviors in patients with upper limb amputations

Cleveland Clinic researchers have engineered a first-of-its-kind bionic arm for patients with upper-limb amputations that allows wearers to think, behave and function like a person without an amputation, according to new findings published in Science Robotics.

1 Sep 2021

Cultured cartilage cells from the nasal septum could help relieve osteoarthritis in the knee

Cartilage cells from the nasal septum can not only help repair cartilage injuries in the knee – according to researchers from the University of Basel and the University Hospital of Basel, they can also withstand the chronic inflammatory tissue environment in osteoarthritis and even counteract the inflammation.

1 Sep 2021

Cellular protein may be a potential new target for treating osteoporosis

A cellular protein whose normal function appears to suppress bone formation may be a potential new target for treating osteoporosis, suggests a collaborative study led by Weill Cornell Medicine and NewYork-Presbyterian investigators.

1 Sep 2021

Nanoparticle-based disinfectant could be a powerful weapon against pathogenic viruses

University of Central Florida researchers have developed a nanoparticle-based disinfectant that can continuously kill viruses on a surface for up to seven days – a discovery that could be a powerful weapon against COVID-19 and other emerging pathogenic viruses.

1 Sep 2021

Do kidney transplant recipients need a third booster dose of mRNA COVID-19 vaccine?

A team of researchers in France have observed that the “standard” 2 dose regimen for mRNA COVID-19 vaccines could provide adequate protection to only a few KTRs. It has also been shown in multiple studies that a considerable population of vaccinated KTRs were easily infected with SARS-CoV-2.

1 Sep 2021

New candidate vaccine for COVID-19 found to be efficacious in preclinical models

More than a year after the start of the COVID-19 pandemic, several vaccines have been authorized thanks to unprecedented worldwide research efforts. These first-generation vaccines bring great hope and are a mainstay in fighting the virus.

1 Sep 2021

Innovative AI and simulation tools used to reveal the inner workings of Sar-CoV-2 virus

Argonne, industry and academia collaborate to bring innovative AI and simulation tools to the COVID-19 battlefront.

1 Sep 2021

Sequential treatment using similar antibiotics can kill bacteria and prevent drug resistance

equential treatment using antibiotics that are similar but swapped around frequently is an effective way to kill bacteria and prevent drug resistance, a study in eLife reports.

1 Sep 2021

Modified R-CODOX-M/IVAC regimen shows promise for treating sporadic Burkitt lymphoma

Burkitt lymphoma (BL) is a highly aggressive form of non-Hodgkin lymphoma (NHL) that comes in three different variants: endemic, immunodeficiency-associated, and sporadic. Of these variants, sporadic BL is most commonly found outside malaria-endemic countries and typically seen in young adults.

1 Sep 2021

New model shows how dysfunction in the air sacs initiates fibrotic cascade

Idiopathic pulmonary fibrosis (IPF) is the most common and severe form of lung disease characterized by relentless scarring leading to death within an average of four years from the time of diagnosis.

31 Aug 2021

Researchers decipher genetic mechanisms governing the speed of protein synthesis

In all eukaryotic organisms, genetic material is stored in the cell nucleus in the form of DNA. In order to be used, this DNA is first transcribed into messenger RNA in the cell cytoplasm, then translated into protein with the help of ribosomes, small machines capable of decoding messenger RNA to synthesise the appropriate proteins.

31 Aug 2021

Does SARS-CoV-2 infection protect against reinfection?

A new review showed that the protective effect of prior SARS-CoV-2 infection is at least equivalent to that of vaccination.

31 Aug 2021

Laboratory News and Research

CAR T cells expressing a natural RNA can activate the body’s own T cells against solid tumors

Research uncovers test to identify iMCD patients with superior response to FDA-approved treatment

World renowned immunologist named chief of Feinberg's Division of Allergy and Immunology

Risk of COVID-19 transmission from animals to older adults

Booster shot of Pfizer COVID-19 vaccine provides additional protection against SARS-CoV-2 infection

Research investigates how drug-eluting stent affects arterial tissue permeability and blood flow

Study identifies how immune sensors launch a multi-faceted innate immune response to infections

Study suggests a biological basis behind instantaneous compatibility reaction

First-of-its-kind bionic arm restores natural behaviors in patients with upper limb amputations

Cultured cartilage cells from the nasal septum could help relieve osteoarthritis in the knee

Cellular protein may be a potential new target for treating osteoporosis

Nanoparticle-based disinfectant could be a powerful weapon against pathogenic viruses

Do kidney transplant recipients need a third booster dose of mRNA COVID-19 vaccine?

New candidate vaccine for COVID-19 found to be efficacious in preclinical models

Innovative AI and simulation tools used to reveal the inner workings of Sar-CoV-2 virus

Sequential treatment using similar antibiotics can kill bacteria and prevent drug resistance

Modified R-CODOX-M/IVAC regimen shows promise for treating sporadic Burkitt lymphoma

New model shows how dysfunction in the air sacs initiates fibrotic cascade

Researchers decipher genetic mechanisms governing the speed of protein synthesis

Does SARS-CoV-2 infection protect against reinfection?

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