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FDA-approved VENTANA anti-ALK CDx more accurate than commonly used IHC assay for patient selection

The U.S. Food and Drug Administration approved VENTANA anti-ALK(D5F3)CDx performed more accurately than another commonly used immunohistochemistry (IHC) assay, based on the use of the 5A4 clone, for the selection of patients eligible to receive ALK tyrosine kinase inhibitor (TKI) treatment.

23 Feb 2016

Patient enrollment completed in vepoloxamer Phase 3 study for treatment of sickle cell disease

Mast Therapeutics, Inc., a biopharmaceutical company developing novel, clinical-stage therapies for sickle cell disease and heart failure today announced that it has completed patient enrollment in its Phase 3 clinical study of vepoloxamer for the treatment of patients with sickle cell disease experiencing vaso-occlusive crisis, known as the EPIC study.

22 Feb 2016

First European advice on emergency care for acute heart failure patients published

The first European advice on emergency care for patients with acute heart failure is published today in European Heart Journal: Acute Cardiovascular Care. Acute heart failure carries a higher risk of death than heart attack but care lags 30 years behind.

22 Feb 2016

Scientists find that lifespan of supportive cells in tumor may control cancer metastasis

Researchers have discovered that eliminating cells thought to aid tumor growth did not slow or halt the growth of cancer tumors. In fact, when the cancer-associated fibroblasts (CAFs), were eliminated after 10 days, the risk of metastasis of the primary tumor to the lungs and bones of mice increased dramatically.

22 Feb 2016

Air pollution exposure increases obesity risk

Laboratory rats who breathed Beijing's highly polluted air gained weight and experienced cardio-respiratory and metabolic dysfunctions after three to eight weeks of exposure.

22 Feb 2016

Sanford Health clinical trial testing effectiveness of investigational cancer drug nivolumab

People with Merkel cell, gynecological, gastric and head and neck cancers may be eligible to participate in a clinical trial at Sanford Health testing the effectiveness of an investigational drug called nivolumab.

18 Feb 2016

Combining pain medicine with metal ions could destroy drug-resistant cancer cells

Fighting chemoresistant cancer remains a huge challenge that scientists are tackling from as many angles as they can. One alternative approach involves pairing two groups of compounds -- pain medicine and metal ions -- that have individually shown promise as anti-cancer agents. Scientists report in the ACS journal Inorganic Chemistry that combining the two led to new compounds that could destroy drug-resistant cancer cells and leave most normal cells alone in lab tests.

18 Feb 2016

African Americans with common genetic variants at increased risk for blood clots

New research published online today in Blood, the Journal of the American Society of Hematology (ASH), identifies common genetic variants predominantly found in African Americans that double their risk for blood clots.

18 Feb 2016

New drug combination shows promise for patients with non-small cell lung cancer

Lung cancer is the most common cause of cancer-related death in the United States resulting in more than 158,000 deaths each year. With a 5-year survival rate at only 18 percent, the development of new and improved treatment options is needed.

18 Feb 2016

Study may lead to potential drug targets for tumor formation in pulmonary tuberous sclerosis complex

In a new study published in the American Association of Cancer Research's journal Cancer Research, a pair of investigators at Rutgers and Columbia universities has identified a gene that may provide a new source of potential drug targets for tumors that arise in pulmonary tuberous sclerosis complex (TSC).

18 Feb 2016

Autoantibodies can potentially detect lung cancer at early stage

Preliminary research has identified autoantibodies, immune proteins found in the blood specific for one's own proteins, that can potentially detect lung cancer early by distinguishing between smokers with or without lung cancer and also discriminate between lung cancer and low-dose computed tomography (LDCT) detected non-cancerous lung lesions.

18 Feb 2016

Graphic anti-smoking images can warn smokers about cigarettes' health consequences

Viewing graphic anti-smoking images on cigarette packs triggers activity in brain areas involved in emotion, decision-making and memory as observed via brain scans.

17 Feb 2016

Studies explore causative factor of hypertension in younger, obese men and women

There's no doubt estrogen plays a big role in the differences between males and females, and now researchers want to know if it also helps explain emerging sex differences in what makes younger, obese men and women hypertensive.

17 Feb 2016

ACC, AHA support implementation of proposed cardiovascular measures, with reservations

Quality measures announced today by the Core Quality Measures Collaborative represent a step forward in reducing paperwork and confusion while also allowing providers to focus on measures that impact patient outcomes, the American College of Cardiology (ACC) and the American Heart Association (AHA) said in support of implementation of the proposed cardiovascular measures. But the groups expressed reservations about blood pressure targets included in the measures.

17 Feb 2016

Early life factors contribute to aging of lungs

Smoking mothers, respiratory infections and the date you were born contribute to determine how fast your lungs are aging.

17 Feb 2016

Helsinn, Mundipharma sign distribution, license and supply agreements for anamorelin

Helsinn, the Swiss pharmaceutical Group focused on building quality cancer care, today announce that they have entered into distribution, license and supply agreements with Mundipharma and its network of independent associated companies granting exclusive rights to anamorelin in Norway, Finland, Sweden, Denmark and Iceland.

16 Feb 2016

Heart attack patients experiencing cardiogenic shock at higher risk of death in first 60 days post-discharge

Heart attack patients who experience cardiogenic shock have a higher risk of death or rehospitalization than non-shock patients in the first 60 days post-discharge, but by the end of the first year, the gap between the two groups narrows, according to a study published today in the Journal of the American College of Cardiology.

16 Feb 2016

Scientists discover new subgroups of ILC immune cells using single-cell RNA sequencing

A relatively newly discovered group of immune cells known as ILCs have been examined in detail in a new study published in the journal Nature Immunology. By analysing the gene expression in individual tonsil cells, scientists at Karolinska Institutet in Sweden have found three previously unknown subgroups of ILCs, and revealed more about how these cells function in the human body.

16 Feb 2016

Variations in Tie2 gene play significant role in patient responses to infections

Major infections such as influenza and bacterial sepsis kill millions of people each year, often resulting fro dangerous complications that impair the body's blood vessels. But the reasons why some patients experience these dramatic responses to infections -- and others don't -- have been unclear.

16 Feb 2016

Confirming nasogastric tube placement through an assay? An interview with Ian Fotheringham

Nasogastric tubes are placed directly into the stomach in order to feed or medicate patients. If an NG tube accidentally goes into the lung instead, which can happen, it can cause serious harm to the patient, with food, liquid or medication potentially entering the lung.

15 Feb 2016

Lungs News and Research

FDA-approved VENTANA anti-ALK CDx more accurate than commonly used IHC assay for patient selection

Patient enrollment completed in vepoloxamer Phase 3 study for treatment of sickle cell disease

First European advice on emergency care for acute heart failure patients published

Scientists find that lifespan of supportive cells in tumor may control cancer metastasis

Air pollution exposure increases obesity risk

Sanford Health clinical trial testing effectiveness of investigational cancer drug nivolumab

Combining pain medicine with metal ions could destroy drug-resistant cancer cells

African Americans with common genetic variants at increased risk for blood clots

New drug combination shows promise for patients with non-small cell lung cancer

Study may lead to potential drug targets for tumor formation in pulmonary tuberous sclerosis complex

Autoantibodies can potentially detect lung cancer at early stage

Graphic anti-smoking images can warn smokers about cigarettes' health consequences

Studies explore causative factor of hypertension in younger, obese men and women

ACC, AHA support implementation of proposed cardiovascular measures, with reservations

Early life factors contribute to aging of lungs

Helsinn, Mundipharma sign distribution, license and supply agreements for anamorelin

Heart attack patients experiencing cardiogenic shock at higher risk of death in first 60 days post-discharge

Scientists discover new subgroups of ILC immune cells using single-cell RNA sequencing

Variations in Tie2 gene play significant role in patient responses to infections

Confirming nasogastric tube placement through an assay? An interview with Ian Fotheringham

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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