Signaling Pathway News and Research

RSS

Clinical investigators present abstracts on hematological malignancies at ASH Annual Meeting and Exposition

Clinical investigators from Hackensack Meridian Health John Theurer Cancer Center (JTCC), a member of the Georgetown Lombardi Comprehensive Cancer Center consortium, are to present updates on treatment advances in multiple myeloma (MM), mantle cell lymphoma (MCL), and other types of B-cell lymphoma (BCL) as well as leukemia at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, to be held virtually from December 5-8, 2020.

7 Dec 2020

Intermediate embryonic stem cell type could lead to advances in regenerative medicine

A team led by UT Southwestern has derived a new "intermediate" embryonic stem cell type from multiple species that can contribute to chimeras and create precursors to sperm and eggs in a culture dish.

4 Dec 2020

Researchers discover why older adults are more susceptible to heart disease

A team of researchers at the University of South Florida Department of Surgery has made a key discovery as to why we become more susceptible to heart disease as we age.

3 Dec 2020

Designed proteins assemble antibodies into modular nanocages

With cues from nature, designing functional molecules enables scientists to nanoengineer and customize for specific uses.

3 Dec 2020

Study outlines a new role for pregnancy-associated plasma protein A in gestational diabetes

Laboratory research and analysis of epidemiological data by Silvia Corvera, MD, and Tiffany Moore Simas, MD, MPH, MEd, and colleagues show that low levels of a protein commonly seen in screening tests for chromosomal disorders during the first trimester of pregnancy is associated with adipose tissue remodeling, glucose resistance and gestational diabetes mellitus in pregnant women.

30 Nov 2020

Researchers identify the gene responsible for cellular aging

In a new study, published today in the journal Stem Cells, researchers reveal how they have identified the gene responsible for aging.

30 Nov 2020

Female reproductive hormones may be protective against COVID-19

In an article recently published in Trends in Endocrinology & Metabolism, Graziano Pinna from the University of Illinois in Chicago outlines some of the evidence suggesting that female reproductive hormones may play a role in the sex bias that has been observed in coronavirus disease 2019 (COVID-19).

29 Nov 2020

Resveratrol shows potential as SARS-CoV-2 antiviral, study finds

A recent study reveals that resveratrol, a phenolic compound produced by spermatophytes, can inhibit the viral replication SARS-CoV-2.

27 Nov 2020

The role of micro-RNA in SARS-CoV-2 infection and COVID-19

A team of researchers based in Iran have explored the role of micro-RNA in COVID-19. Their study titled, “The emerging role of microRNAs in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection,” was published in the latest issue of the journal International Immunopharmacology.

24 Nov 2020

Early, late stages of neurodegeneration are distinct, finds study

Rice University biochemists Michael Stern and James McNew have studied how neurodegeneration kills cells.

23 Nov 2020

Discovery reveals a fundamental way cells interpret signals from the environment

A basic science discovery by researchers at the Johns Hopkins Bloomberg School of Public Health reveals a fundamental way cells interpret signals from their environment and may eventually pave the way for potential new therapies.

20 Nov 2020

Study shows how rotavirus leads to severe gastrointestinal disease

Rotavirus is a major cause of diarrhea and vomiting, especially in children, that results in approximately 128,000 deaths annually.

20 Nov 2020

Scientists discover potential strategy to prevent inflammation in COVID-19 patients

The COVID-19 pandemic continues to cause significant illness and death while treatment options remain limited. St. Jude Children's Research Hospital scientists have discovered a potential strategy to prevent life-threatening inflammation, lung damage and organ failure in patients with COVID-19. The research appeared online in the journal Cell.

19 Nov 2020

Human coronaviruses cause processing body loss

Researchers continue to expand their knowledge of coronaviruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen. Now, a new study published on the preprint server bioRxiv in November 2020 describes a vital mechanism whereby the novel SARS-CoV-2 pathogen can restrict the human host response. In doing so, the study explores how this novel feature of SARS-CoV-2 works and how it results in a reshaping of the human host's immune response.

11 Nov 2020

Antiangiogenic drugs increase the aggressiveness of some kidney tumors

Angiogenesis is the process by which tumors create new blood vessels that will provide them the nutrients to continue growing.

5 Nov 2020

Researchers develop novel therapeutic approach against COPD

Chronic obstructive pulmonary disease (COPD) is one of the most common and deadliest diseases worldwide.

4 Nov 2020

"Training" the immune system with β-glucan compound may improve immune recovery

Immunotherapies, such as checkpoint inhibitor drugs, have made worlds of difference for the treatment of cancer.Most clinicians and scientists understand these drugs to act on what's known as the adaptive immune system, the T cells and B cells that respond to specific threats to the body.

30 Oct 2020

Study: Mammary basal cell lineage contributes to breast cancer heterogeneity

A key hurdle in treating breast cancers is intratumoral heterogeneity, or the presence of multiple different cell populations within the same tumor that have distinct characteristics such as gene expression, metabolism and ability to divide, spread and grow.

29 Oct 2020

Researchers report the discovery of innate immune signaling pathway in fibroblasts

Vanderbilt University researchers have reported the counterintuitive discovery that certain chemotherapeutic agents used to treat tumors can have the opposite effect of tissue overgrowth in normal, intact mammary glands, epidermis and hair follicles.

16 Oct 2020

Moffitt study uncovers how specific molecules promote cancer progression

The development of cancer is a highly complicated process, involving multiple genes and signaling pathways that become upregulated or downregulated throughout different stages of tumor growth and spread.

15 Oct 2020