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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Femtogenix announces efficacy, toxicity data of new DNA-binding ADC payload molecules

Femtogenix Ltd, a UK biotechnology company developing the next generation of DNA-interactive Antibody Drug Conjugate (ADC) payloads, today announced data verifying the favorable toxicity profile and potent efficacy of its Pyridinobenzodiazepine (PDD) ADC payload platform in tumor cell models.

14 Oct 2019

Porvair Sciences to showcase new range of microplates at Lab Innovations 2019

Porvair Sciences will showcase its recently extended ranges of ultra-clean deep well and assay microplates for the first time in Europe at the forthcoming Lab Innovations 2019 exhibition.

From Porvair Sciences Limited 14 Oct 2019

Antibody-based eye drop treatment reduces signs and symptoms of dry eye disease

Researchers at the University of Illinois at Chicago are the first to identify the presence of a specific type of antibody, called anti-citrullinated protein autoantibodies, or ACPAs, in human tear fluid.

11 Oct 2019

Repurposed quinacrine can reduce tumor burden in mice bearing HNSCC xenograft tumors

The authors have developed the Accelera TED platform to repurpose drugs for HNSCC treatment; using in vitro assays and in vivo models.

11 Oct 2019

New genomics technique can be used to track down the causes of rare genetic diseases

A team led by a scientist at Scripps Research has invented a new genomics technique for tracking down the causes of rare genetic diseases.

11 Oct 2019

New gene therapy for wet age-related macular degeneration is on the horizon

Gene therapy is showing promise for one of the most common causes of blindness. Data presented today shows that six patients with wet age-related macular degeneration have, so far, gone at least six months without the need for continued injections to control a disease that typically requires treatment every four to six weeks.

11 Oct 2019

Jumping genes can contribute to rare childhood developmental disorders

The largest study of its kind into childhood developmental disorders has discovered that jumping genes cause genetic changes in some patients with undiagnosed neurodevelopmental diseases.

11 Oct 2019

Researchers develop customized drug treatment to bypass patient’s unique mutation

An unprecedented case at Boston Children's Hospital shows that it's possible to do something that's never been done before: identify a patient's unique mutation, design a customized drug to bypass it, manufacture and test the drug, and obtain permission from the Food and Drug Administration (FDA) to begin treating the patient -- all in less than one year.

11 Oct 2019

New study shows how immune cells process and use energy

For years, scientists have used cells grown in petri dishes to study the metabolic processes that fuel the immune system. But a new report in Immunity suggests looking outside the dish and into living organisms gives a drastically different view of the way immune cells process and use energy.

11 Oct 2019

Structural biology reveals 3D structure of asthma-linked receptor

A new study has laid bare the structure of a protein receptor called the CysLT1 receptor that is implicated in a range of allergic and cardiovascular conditions as well as some types of cancer. Published in Science Advances, the paper shows how the researchers used structural biology techniques to accomplish this feat.

10 Oct 2019

Genetic mechanisms could serve as a road map for screening new drugs to prolong healthy lifespan

The discovery in the 1990s that a mutation in a single gene of an experimental worm could double its lifespan set off a stampede of research on the molecular biology of aging and triggered hopes that drug therapies or other interventions could be developed to extend healthy human lifespan. But as is often the case in science, the genetic regulation of aging is more complicated than it first appeared.

10 Oct 2019

Study pinpoints a gene that allows chlamydia to pick up DNA from host environment

According to the Centers for Disease Control and Prevention, chlamydia trachomatis is the most commonly reported sexually transmitted bacterial disease in the U.S., totaling 1.7 million cases in 2017. Rates are highest among teenagers and young adults. Left untreated, chlamydia can cause blindness and sterility.

10 Oct 2019

Researchers identify genetic mutation that causes idiopathic pulmonary fibrosis

Researchers in Japan have identified a genetic mutation that causes a severe lung disease called idiopathic pulmonary fibrosis by killing the cells lining the lung's airways.

10 Oct 2019

BIA Separations launches CORNERSTONE Exosome Process Development Solution

BIA Separations, a leading bio-chromatography development and manufacturing company, today announced the introduction of its CORNERSTONE Exosome Process Development Solution, designed to help drug-developers overcome critical development bottlenecks in the preparation of exosomes for clinical use.

10 Oct 2019

Scientists find new evidence on latent HIV reservoir

Antiretroviral therapy (ART) can suppress HIV to the point where the virus is nearly undetectable, and people on medication can live many years.

10 Oct 2019

Scientists solve a longstanding challenge in portable diagnostic devices

If you've ever stopped to watch rain falling on a windowpane, you've seen what happens when two drops of water touch and merge into one.

10 Oct 2019

How do gallstones form?

The human body is known to produce stones in various locations, most commonly in the kidneys, the bladder, the gallbladder and the appendix. Many of these stones appear without any obvious reason. However, a new study published in the journal Immunity shows the whole storyline for the first time: how gallstones are formed.

9 Oct 2019

UD engineering professor receives NIH grant to accelerate study of lung fibrosis

University of Delaware Professor April Kloxin has been awarded a National Institutes of Health Director's New Innovator Award from the NIH Common Fund's High-Risk, High-Reward Research program, which supports highly innovative research proposals.

9 Oct 2019

Initial use of ART alters host environment to allow formation of long-lived HIV reservoir

Antiretroviral therapy (ART) can suppress HIV to the point where the virus is nearly undetectable, and people on medication can live many years. But therapy cannot completely eradicate the virus; it persists in reservoirs inside immune cells, a phenomenon called "latency."

9 Oct 2019

Novel cancer-driving mutation discovered in vast non-coding regions of the cancer genome

An Ontario-led research group has discovered a novel cancer-driving mutation in the vast non-coding regions of the human cancer genome, also known as the "dark matter" of human cancer DNA.

9 Oct 2019

DNA News and Research

Further Reading

Femtogenix announces efficacy, toxicity data of new DNA-binding ADC payload molecules

Porvair Sciences to showcase new range of microplates at Lab Innovations 2019

Antibody-based eye drop treatment reduces signs and symptoms of dry eye disease

Repurposed quinacrine can reduce tumor burden in mice bearing HNSCC xenograft tumors

New genomics technique can be used to track down the causes of rare genetic diseases

New gene therapy for wet age-related macular degeneration is on the horizon

Jumping genes can contribute to rare childhood developmental disorders

Researchers develop customized drug treatment to bypass patient’s unique mutation

New study shows how immune cells process and use energy

Structural biology reveals 3D structure of asthma-linked receptor

Genetic mechanisms could serve as a road map for screening new drugs to prolong healthy lifespan

Study pinpoints a gene that allows chlamydia to pick up DNA from host environment

Researchers identify genetic mutation that causes idiopathic pulmonary fibrosis

BIA Separations launches CORNERSTONE Exosome Process Development Solution

Scientists find new evidence on latent HIV reservoir

Scientists solve a longstanding challenge in portable diagnostic devices

How do gallstones form?

UD engineering professor receives NIH grant to accelerate study of lung fibrosis

Initial use of ART alters host environment to allow formation of long-lived HIV reservoir

Novel cancer-driving mutation discovered in vast non-coding regions of the cancer genome

eBook: Exploring the Cell Cycle and DNA Damage and Repair eBook

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How can microdialysis benefit drug development

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