Signaling Pathway News and Research

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Study identifies a protein and signaling pathway that may contribute to sudden cardiac death

By studying the sick hearts removed from four patients undergoing heart transplants, researchers have identified a protein and a signaling pathway that may contribute to sudden death in an inherited form of heart disease.

3 Mar 2020

Major investment can help improve technology aimed at turning bad fat to good fat

A significant investment from a Purdue University alumnus and his wife will help further develop technology aimed at treating obesity and diabetes by turning bad fat into good fat inside the body.

28 Feb 2020

New study expands the knowledge on tumor-suppressor role of HERC proteins

The RAF protein could be a therapeutical target to treat the tumor growth in regulated pathways by the p38 protein, according to a new study published in the journal Scientific Reports by a team of experts of the Faculty of Medicine and Health Sciences of the University of Barcelona and the Bellvitge Institute for Biomedical Research.

20 Feb 2020

UCLA researchers identify new molecule that promotes airway health

A molecule identified by UCLA researchers helps maintain a healthy balance of cells in airway and lung tissue.

18 Feb 2020

Breakthrough discovery could open up new treatments for some blood cancers

Reversing runaway inflammation in the bone marrow could lead to major breakthroughs in treatments for some blood cancers, according to a new publication by scientists at Hackensack Meridian Health's Center for Discovery and Innovation.

16 Feb 2020

Study provides a detailed molecular snapshot of endometrial cancer

A study published Feb. 13 in Cell provides an unprecedented look at the dozens of molecular steps that occur to bring about endometrial cancer, commonly known as uterine cancer.

14 Feb 2020

Molecular study defines the contributions of key genes, proteins to endometrial cancer

The most comprehensive molecular study of endometrial cancer to date has further defined the contributions of key genes and proteins to the disease, say its authors.

13 Feb 2020

Metformin could help leaky gut

A team of researchers from University of California, San Diego, have successfully used gut organoids in their lab to show the effects of medications to treat conditions such as “leaky gut”. The study was titled, “The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer,” and was published in the journal Life Science Alliance today.

10 Feb 2020

Researchers simulate leaky gut conditions using 3D models of human intestines

Once a vague scapegoat for a variety of ills, increasing evidence suggests a condition known as "leaky gut" -- in which microbes and other molecules seep out of the intestines -- may be more common, and more harmful, than previously thought.

10 Feb 2020

Cedars-Sinai researchers to study role of fat in promoting cancer spread to liver

A diagnosis of pancreatic or colon cancer often sparks dread about the disease's likely next destination: the liver. That's because liver metastasis is a leading cause of death in these patients.

6 Feb 2020

Heart muscle cells of zebrafish change their metabolism during heart regeneration

Researchers from the group of Jeroen Bakkers at the Hubrecht Institute have found that the muscle cells in the heart of zebrafish change their metabolism, the way in which they generate energy, during heart regeneration.

5 Feb 2020

Yale researchers find way to reverse type-2 diabetes and liver fibrosis in mice

In a pair of related studies, a team of Yale researchers has found a way to reverse type-2 diabetes and liver fibrosis in mice and has shown that the underlying processes are conserved in humans.

4 Feb 2020

RNA affecting skin cancer progression discovered

Researchers at the University of Turku, Turku University Central Hospital, and Western Cancer Center have discovered a new RNA molecule, PRECSIT, which regulates the growth and invasion of squamous cell carcinoma of the skin.

4 Feb 2020

Reduced scar formation in the central nervous system

Neural stem and progenitor cells, from the so-called subventricular zone, can help to repair a brain damaged by central nervous system disorders.

3 Feb 2020

Discovery about how cancer cells hide from the immune system could improve treatments

Researchers have shed light on the mechanism through which cancer cells become camouflaged to escape immune system detection and attack.

31 Jan 2020

Death receptor pathway drives resistance to CAR T cell therapy

Some cancer cells refuse to die, even in the face of powerful cellular immunotherapies like CAR T cell therapy, and new research from the Abramson Cancer Center of the University of Pennsylvania is shedding light on why.

30 Jan 2020

Avacta demonstrates initial proof-of-concept for TMAC drug conjugates in pre-clinical study

Avacta Group plc, the developer of Affimer biotherapeutics and reagents, is pleased to announce that it has demonstrated initial proof-of-concept for its proprietary new class of drug conjugate, TMAC, in a pre-clinical animal model of cancer.

From Avacta Life Sciences Ltd. 28 Jan 2020

Molecular biologists identify gene that puts brakes on tissue growth

The planarian flatworm is a simple animal with a mighty and highly unusual ability: it can regenerate itself from nearly every imaginable injury, including decapitation. These tiny worms can regrow any missing cell or tissue -- muscle, neurons, epidermis, eyes, even a new brain.

22 Jan 2020

Study reveals new mechanism involved in the pathogenesis of IBD

Inflammatory bowel disease is a category of refractory inflammatory disease, of which ulcerative colitis and Crohn's disease are the main types.

21 Jan 2020

Study shows how extracellular vesicles help melanoma cells to spread

A new study from Finland sheds fresh light on how melanoma cells interact with other cells via extracellular vesicles they secrete.

16 Jan 2020