Signaling Pathway News and Research

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Scientists identify pathway for treatment-resistant lung cancer

A big way chemotherapy works is by prompting cancer cells to commit suicide, and scientists have found a pathway the most common lung cancer walks to avoid death.

20 Sep 2019

NMDAR receptor is responsible for breast-to-brain metastases, shows study

In 2018, breast cancer was the most common cancer in women worldwide, accounting for about a quarter of all reported cancers. One of the biggest problems with any type of cancer is metastasis; and when breast cancer metastasizes, the brain is a common destination.

19 Sep 2019

Metastatic colorectal cancer patients with certain BRAF mutations may respond to anti-EGFR therapy

Patients with metastatic colorectal cancer harboring a subset of non-V600 mutations in the BRAF gene, known as class 3 BRAF mutations, were more likely to respond to anti-EGFR treatment.

12 Sep 2019

Researchers develop new cocktail of drugs that shrink pancreatic tumors

Cancer is relentless and resilient. When a drug blocks a cancer cell's main survival pathway, the cell avoids the obstacle by taking different pathways or detours to save itself. This tactic is called "developing resistance," and it's one of the key challenges researchers face when seeking effective therapeutics to combat pancreatic ductal adenocarcinoma (PDA).

9 Sep 2019

Researchers discover a molecule that regulates tumor development in different types of cancers

Researchers from the Josep Carreras Leukemia Research Institute, discover that a non-coding region of the genome originates a key molecule for the proliferation of tumors in breast cancer and some types of sarcoma.

5 Sep 2019

Breast cancer gene could be key to developing targeted therapy for hepatoblastoma

Hepatoblastoma is a rare form of liver cancer affecting just a few individuals per million. However, it is the leading cause of liver cancer in infants and young children, with most patients diagnosed before their third birthday.

4 Sep 2019

Danish-American researchers find new way to treat chronic inflammation

Researchers from Aarhus University Hospital and Aarhus University in Denmark in collaboration with researchers from Colorado in the United States have found a new way to treat the inflammation involved in chronic diseases such as psoriasis, asthma and HIV.

30 Aug 2019

Hyperactive signaling pathway blocks cell division in the aging brain

Scientists from Basel have investigated the activity of stem cells in the brain of mice and discovered a key mechanism that controls cell proliferation.

29 Aug 2019

New study helps explain why lung tumors turn aggressive

Lung cancer is the number 1 killer among cancers, especially when it is of the non-small cell type. Among these, adenocarcinomas are the most common and aggressive type. These tumors also show a strong tendency to show dedifferentiation, or loss of the features that characterize a mature lung cell.

28 Aug 2019

New cellular processes controlling the formation of lymphatic valves found

Lymphedema, resulting from a damaged lymphatic system, can be a debilitating disease in which excess protein-rich fluid (lymph) collects in soft tissues and causes swelling -- most often in the arms or legs.

28 Aug 2019

U of T scientists create antibodies with enormous potential for regenerative medicine

Our body makes antibodies to fight infections. But the synthetic versions of these molecules could hold the key to stimulating the body's ability to regenerate.

27 Aug 2019

Ketogenic diet shown to support intestinal stem cells

Scientists have discovered that ketone bodies produced during the ketogenic diet trigger the proliferation of intestinal stem cells in adults.

26 Aug 2019

Ohio University scientists win $1.7 million grant for research on non-melanoma skin cancers

The National Institute of Environmental Health Sciences has awarded Ohio University scientists Shiyong Wu and Lingying Tong a five-year $1.7 million grant to advance research on a potential prevention and treatment for non-melanoma skin cancers.

20 Aug 2019

Researchers identify compounds that influence time to sexual maturity and lifespan

Every day, people are exposed to myriad chemicals, both natural and synthetic. Some of these compounds may affect human physical development, but testing them directly on people would be grossly unethical.

20 Aug 2019

Study: Blocking inflammatory pathway could prevent melanoma brain metastasis

Brain metastases are among the deadliest tumor metastases, with a median survival period of less than one year, and the incidence of brain metastasis is rising.

20 Aug 2019

Study uncovers potential new treatment approach for lung cancer

Lung cancer is the second most common cancer found in both men and women. It is estimated there will be roughly 228,000 new lung cancer cases this year, and nearly 30% of those patients will have mutations in the KRAS pathway.

19 Aug 2019

Lipid signaling pathway may enhance T cell-mediated immunotherapy

The immune system surveils our body looking for things that don't belong, often bacteria and viruses. While cancer cells are abnormal cells that undergo unregulated cell growth, they are good at evading detection by the immune system.

19 Aug 2019

SLU researchers receive $2.1 million to find non-addictive pain medications

Neuropathic pain affects between 15 and 20 million people in the U.S. This type of pain can occur after injuries to the nervous system due to trauma, disease or exposure to neurotoxins, including after chemotherapy.

19 Aug 2019

Fruit fly model for studying diseases like gout, kidney stones reveals new drug targets

A new fruit fly model that mimics diseases associated with high uric acid levels, such as gout and kidney stones, has revealed new targets for developing treatments for these diseases.

From PLOS ONE 16 Aug 2019

Resurrecting protein ancestors yields evolutionary insights into their role in human cells

"Resurrecting" the ancestors of key proteins yields evolutionary insights into their role in human cells and in most cancers, a new study finds.

14 Aug 2019

Signaling Pathway News and Research

Scientists identify pathway for treatment-resistant lung cancer

NMDAR receptor is responsible for breast-to-brain metastases, shows study

Metastatic colorectal cancer patients with certain BRAF mutations may respond to anti-EGFR therapy

Researchers develop new cocktail of drugs that shrink pancreatic tumors

Researchers discover a molecule that regulates tumor development in different types of cancers

Breast cancer gene could be key to developing targeted therapy for hepatoblastoma

Danish-American researchers find new way to treat chronic inflammation

Hyperactive signaling pathway blocks cell division in the aging brain

New study helps explain why lung tumors turn aggressive

New cellular processes controlling the formation of lymphatic valves found

U of T scientists create antibodies with enormous potential for regenerative medicine

Ketogenic diet shown to support intestinal stem cells

Ohio University scientists win $1.7 million grant for research on non-melanoma skin cancers

Researchers identify compounds that influence time to sexual maturity and lifespan

Study: Blocking inflammatory pathway could prevent melanoma brain metastasis

Study uncovers potential new treatment approach for lung cancer

Lipid signaling pathway may enhance T cell-mediated immunotherapy

SLU researchers receive $2.1 million to find non-addictive pain medications

Fruit fly model for studying diseases like gout, kidney stones reveals new drug targets

Resurrecting protein ancestors yields evolutionary insights into their role in human cells

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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