Signaling Pathway News and Research

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Researchers reveal important signaling pathway in breast cancer

Researchers at Kanazawa University report in Proceedings of the National Academy of Sciences of the United States of America that a particular signaling pathway in breast-cancer tumors causes cancer cells to divide symmetrically, expanding the tumor. Inhibiting the pathway by drugs could become a strategy for eliminating the cancer cells.

24 Jan 2019

Defective molecular master switch could lead to age-related macular degeneration

A signaling pathway controlled by transforming growth factor beta (TGF-beta) could be involved in the progression of age-related macular degeneration.

22 Jan 2019

TGF-beta signaling pathway in uterine cells protects against cancer

Two new mouse models of uterine cancer shed light on how this disease - the most common gynecological cancer in the U.S. - happens.

16 Jan 2019

Hypertension drug may improve effectiveness of ovarian cancer treatment

A new study from a Massachusetts General Hospital research team has found that the hypertension drug losartan, which targets the angiotensin signaling pathway, may improve the effectiveness of chemotherapy agents used to treat ovarian cancer

16 Jan 2019

New evidence shows how fever alters immune cells

Fever is known to help power up our immune cells, and scientists in Shanghai have new evidence explaining how.

16 Jan 2019

Researchers manipulate T cells to improve transplant success

Researchers have manipulated T cells in a way that prevents the rejection of transplanted organs, without affecting the immune system’s ability to fight microbial infection.

15 Jan 2019

UCR researchers uncover how plants sense temperature

When it gets hot outside, humans and animals have the luxury of seeking shelter in the shade or cool, air-conditioned buildings. But plants are stuck.

14 Jan 2019

Identifying genetic factors that lead to squamous cell carcinoma

Skin cancer is on the rise in the United States. Squamous cell carcinoma, the second most common form of cancer in the U.S., has the highest mortality rate of all non-melanoma skin cancers. In roughly two to five percent of patients, the disease will metastasize and spread throughout the body, making it difficult to treat.

14 Jan 2019

Researchers identify promising therapeutic option to treat multiple sclerosis

Researchers at the Medical Center of Johannes Gutenberg University Mainz (JGU) identified an innovative and promising therapeutic option to treat multiple sclerosis.

10 Jan 2019

USC research could lay foundation for a vaccine against tick-borne virus

Two groundbreaking discoveries by USC researchers could lead to medications and a vaccine to treat or prevent a hemorrhagic fever transmitted by a new tick species before it spreads across the United States.

7 Jan 2019

A small protein plays key role in how cancer stem cells differentiate

A jagged little protein appears to be key to how cancer stem cells differentiate and enable metastasis, according to researchers at Rice University and the Duke University School of Medicine.

4 Jan 2019

Bulldogs' screw tails linked to rare inherited syndrome in humans

With their small size, stubby faces and wide-set eyes, bulldogs, French bulldogs and Boston terriers are among the most popular of domestic dog breeds. Now researchers at the University of California, Davis, School of Veterinary Medicine have found the genetic basis for these dogs' appearance, and linked it to a rare inherited syndrome in humans.

3 Jan 2019

Study reveals how molecular mechanisms regulate lysosomal exocytosis by phagocytes

Lysosomes are filled with more than 50 different hydrolytic enzymes, which are capable of digesting most cellular components.

23 Dec 2018

Research suggests a promising therapeutic target to treat or prevent metabolic disorders

Research led by Suresh Alahari, PhD, Fred Brazda Professor of Biochemistry and Microbiology at LSU Health New Orleans, suggests a novel protein may be a promising therapeutic target to treat or prevent metabolic disorders.

18 Dec 2018

Research identifies nerve-signaling pathway behind sustained pain after injury

A toddler puts her hand on a hot stove and swiftly withdraws it. Alas, it's too late--the child's finger has sustained a minor burn. To soothe the pain, she puts the burned finger in her mouth.

13 Dec 2018

Virginia Tech and UC San Diego researchers team up to develop nonopioid drug for chronic pain

Researchers from the Virginia Tech School of Neuroscience are teaming with the University of California San Diego and the U.S. National Institutes of Health to develop a drug -- now in its earliest stages -- that can treat certain types of chronic pain without the addictive consequences of opioids.

12 Dec 2018

Researchers report novel findings on plant hormone

Jasmonic acid is not just the aromatic odor of the plant Jasminum grandiflorum used in cosmetics and perfume industries. Plants wounded by e.g. chewing herbivores produce jasmonic acid as a defense signal, as a phytohormone to mount their defense responses - this includes for example the formation of toxic substances.

10 Dec 2018