Signaling Pathway News and Research

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Researchers discover how a protein complex safeguards against certain brain tumors

Researchers have discovered how a molecule can help prevent certain types of brain tumors by recognizing and 'disarming' harmful proteins that cause them.

5 Sep 2018

Research reveals noise-canceling mechanisms in developmental biology

Noise is usually considered a nuisance, for example when preventing us from clearly hearing what someone is saying. The general concept of noise applies more broadly. In biology, the physical differences between organisms of the same type, for example two humans, originate from so-called developmental noise -- ultimately stemming from probabilistic collisions between reacting molecules and environmental conditions in cells during the early stages of the organism's growth.

4 Sep 2018

Novel lentiviral model can determine effect of Wnt/β-Catenin inhibition on bone regeneration

Researchers have developed a novel tool for determining the sensitivity of bone healing to inhibition of the Wnt signaling pathway and have validated its use in a study of bone regeneration in mice.

4 Sep 2018

Dopamine receptor study opens door to targeted treatments for neuropsychiatric disorders

New work from researchers at Columbia University Vagelos College of Physicians and Surgeons sheds light on how dopamine receptors signal within cells, opening the door for more targeted--and more tolerable--therapeutics to treat an array of neuropsychiatric disorders.

4 Sep 2018

Scientists identify 'Achilles heel' of anaplastic large-cell lymphomas

Anaplastic large-cell lymphomas are rare cancers of the white blood cells. New research from the international ERIA consortium, led by scientists in Vienna, has now shown that the same signaling pathway is essential to the growth of cancer cells in various forms of ALCL: TYK2 (tyrosine kinase 2, an important component of the immune system) prevents apoptotic cell death by increasing the production of Mcl1, a special type of protein belonging to the BCL2 family.

3 Sep 2018

Genetic mutations may drive tumor formation by blurring growth signals

Genetic mutations in a form of non-small cell lung cancer (NSCLC) may drive tumor formation by blurring cells' perception of key growth signals, according to a new laboratory study published August 31, 2018 in Science.

3 Sep 2018

Neurons play active role in triggering a defense mechanism that leads to their own damage

Rasmussen's encephalitis is a rare autoimmune disease that primarily affects children and can lead to seizures.

31 Aug 2018

TGHRI scientists detail role of insulin as a boost to the immune system

The role of insulin as a boost to the immune system to improve its ability to fight infection has been detailed for the first time by Toronto General Hospital Research Institute scientists.

30 Aug 2018

Modified T lymphocytes prevent nerve cell damage in encephalitis

Scientists have found a way to prevent neuron death in Rasmussen’s encephalitis, by exploiting T lymphocytes in the immune system.

30 Aug 2018

Dectin-1 pathway could be important new target for treatment of candidiasis, study shows

Candida albicans infection (candidiasis) can cause skin, genital, or oral pain. Many studies have attempted to understand the source of pain in candidiasis; none have provided a clear explanation, until now.

29 Aug 2018

A non-canonical approach may improve radiation treatment for cancer

Although the success or failure of radiation therapy for cancer has long been associated with the intrinsic radio-resistance or radio-sensitivity of tumor cells, a new approach is demonstrating that radiation can take credit for an additional benefit -; causing highly effective secondary immune responses that can enhance anti-tumor immunity.

28 Aug 2018

Protein modifications that indicate disease

Researchers from the University of Zurich can, for the first time, precisely characterize the protein modification ADP-ribosylation for all proteins in a tissue sample.

28 Aug 2018

Delivering miRNAs to treat patients with inflammatory bowel disease

Inflammatory bowel disease, such as Crohn disease and ulcerative colitis, are chronic inflammatory diseases of unknown cause, and the number of IBD patients is on the rise.

28 Aug 2018

Researchers identify series of molecules involved in regeneration of damaged nerves

Researchers at Nagoya University have identified the series of molecules involved in the regeneration of damaged nerves in roundworm, showing that it largely overlaps with the signals used by the intrinsic removal system to take up and process dying cells.

24 Aug 2018

Study findings shed light on fundamental feature of nerve repair

Through a study of roundworm nerve cells with severed axons, researchers at Nagoya University showed that a signaling cascade that normally functions in promoting the phagocytosis of apoptotic cells also acts in inducing axon regeneration.

24 Aug 2018

Advanced microscopes determine structure of molecular complex implicated in several cancers

In a study published today in Science, UT Southwestern and Rockefeller University researchers used advanced microscopes to determine at atomic resolution the structure of a molecular complex implicated in birth defects and several cancers.

24 Aug 2018

Researchers complete testing a new drug to treat rheumatoid arthritis

An international research group led by Charité - Universitätsmedizin Berlin has completed testing a new drug to treat rheumatoid arthritis.

23 Aug 2018

Research identifies cell signaling pathways related to endocannabinoid system in worms

Like mammals, parasitic worms have an endocannabinoid system that may help the worm and the hosts it infects survive by reducing pain and inflammation in the host, according to a "wild" new discovery by an interdisciplinary research team at the University of California, Riverside.

23 Aug 2018

UTA researcher receives NIH grant to explore ways to boost innate immunity

A UTA researcher has won a five-year, $1.8 million grant from the National Institutes of Health to look at new ways to harness the body's own defense responses to fight pathogens like bacteria.

21 Aug 2018

Aravive Biologics gains Fast Track Designation for AVB-S6-500 from U.S. FDA

Aravive Biologics, Inc. announced today that the U.S. Food and Drug Administration has granted Fast Track Designation to AVB-S6-500 as a potential treatment for platinum-resistant recurrent ovarian cancer.

20 Aug 2018

Signaling Pathway News and Research

Researchers discover how a protein complex safeguards against certain brain tumors

Research reveals noise-canceling mechanisms in developmental biology

Novel lentiviral model can determine effect of Wnt/β-Catenin inhibition on bone regeneration

Dopamine receptor study opens door to targeted treatments for neuropsychiatric disorders

Scientists identify 'Achilles heel' of anaplastic large-cell lymphomas

Genetic mutations may drive tumor formation by blurring growth signals

Neurons play active role in triggering a defense mechanism that leads to their own damage

TGHRI scientists detail role of insulin as a boost to the immune system

Modified T lymphocytes prevent nerve cell damage in encephalitis

Dectin-1 pathway could be important new target for treatment of candidiasis, study shows

A non-canonical approach may improve radiation treatment for cancer

Protein modifications that indicate disease

Delivering miRNAs to treat patients with inflammatory bowel disease

Researchers identify series of molecules involved in regeneration of damaged nerves

Study findings shed light on fundamental feature of nerve repair

Advanced microscopes determine structure of molecular complex implicated in several cancers

Researchers complete testing a new drug to treat rheumatoid arthritis

Research identifies cell signaling pathways related to endocannabinoid system in worms

UTA researcher receives NIH grant to explore ways to boost innate immunity

Aravive Biologics gains Fast Track Designation for AVB-S6-500 from U.S. FDA

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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