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Thrombospondin-1 contributes to development of aortic aneurysm in mice and humans, study finds

Researchers centered at the University of Tsukuba and Kansai Medical University in Japan reveal matricellular protein Thrombospondin-1 (Thbs1) contributes to the development of aortic aneurysm in mice and humans.

20 Aug 2018

Researchers identify way to grow immune cells at large scale for preventing cancer reoccurrence

For the first time, Mount Sinai researchers have identified a way to make large numbers of immune cells that can help prevent cancer reoccurrence, according to a study published in August in Cell Reports.

15 Aug 2018

A class of proteins shown to be effective in reducing drug-seeking behaviors

A class of proteins that has generated significant interest for its potential to treat diseases, has for the first time, been shown to be effective in reducing relapse, or drug-seeking behaviors, in a preclinical study.

14 Aug 2018

UAB study shows how ion channel differentiates newborn and mature neurons in the brain

The dentate gyrus of the hippocampus is part of the brain that helps form memories. It is also one of just two areas in the adult brain where new neurons are continuously formed.

13 Aug 2018

Scientists uncover mechanisms responsible for development of fibrosis

Idiopathic pulmonary fibrosis is an incurable lung disease of unknown origin with limited treatment options. Research suggests that the signaling molecule WNT5A plays a key role in the pathogenic process.

10 Aug 2018

Ground-breaking discovery offers new hope for treatment of Alzheimer’s, other neurological diseases

There is new hope for the treatment of Alzheimer’s and other neurological diseases following a ground-breaking discovery made by an Australian-Chinese research collaboration.

10 Aug 2018

Novel discovery offers hope for treatment of Alzheimer's and other neurological diseases

There is new hope for the treatment of Alzheimer's and other neurological diseases following a ground-breaking discovery made by an Australian-Chinese research collaboration.

10 Aug 2018

Silencing of GULP1 gene expression plays important role in ovarian carcinogenesis

Johns Hopkins researchers in collaboration with Insilico Medicine, a biotechnology company based in Rockville Maryland, identify that silencing of the GULP1 gene expression by methylation plays an important role in ovarian carcinogenesis.

7 Aug 2018

Researchers find ways to render curcumin soluble and deliver it to infected tumors

In India and other countries in Southeast Asia, curcumin is often used as a spice in cooking, particularly chicken or fish. It is known for its therapeutic effect and as a way to kill germs present in raw meet.

7 Aug 2018

Researchers develop 3D model of human placenta

The placenta is the organ connecting mother and embryo. Its main functions are the exchange of nutrients, gases and metabolic products and the production of hormones and other substances essential for embryonic development.

3 Aug 2018

Researchers discover key piece for slowing colorectal cancer subtype

Inhibiting the Jagged 1 protein in mice prevents the proliferation and growth of colon and rectal tumors. What is more, this approach to the disease permits the removal of existing tumors.

2 Aug 2018

Newly identified target may lead to discovery of treatments for chronic inflammatory diseases

Inflammation is part of the body's natural healing process. But when it becomes chronic, inflammation can lead to cancer, Alzheimer's disease and other conditions.

26 Jul 2018

New control system regulates morphology, orientation of cells constituting animal tissues

A collaborative research group led by Kumamoto University has developed a new control system for regulating the morphology and orientation of cells that constitute animal tissues.

25 Jul 2018

'Hijacked' cell response to stress reveals potential therapeutic targets for leukemia

A signaling pathway that helps promote normal cell growth worsens a form of leukemia by taking control of another pathway better known for protecting cells from biological stress, a new study shows.

24 Jul 2018

Homogenous BTK occupancy assay used in tirabrutinib clinical studies

In a new SLAS Discovery article, Helen Yu and a team of researchers at Gilead Sciences, Inc. present a time-resolved fluorescence resonance energy transfer-based Bruton's tyrosine kinase occupancy assay that can measure target engagement in peripheral blood mononuclear cells and in lymph-node and bone-marrow samples.

17 Jul 2018

3D modeling of drug resistance could lead to more effective cancer treatment

The National Institutes of Health is funding the research of a University of Akron scientist that could lead to more effective cancer treatment.

16 Jul 2018

Researchers describe key role of enzyme in regulating immune response against Chagas disease parasite

In an article published recently in the journal Nature Communications, researchers affiliated with the University of São Paulo in Brazil describe the central role played by an enzyme called phosphatidylinositol 3-kinase gamma in regulating the immune response against Trypanosoma cruzi, the protozoan parasite that causes Chagas disease.

16 Jul 2018

Signaling Pathway News and Research

Thrombospondin-1 contributes to development of aortic aneurysm in mice and humans, study finds

Researchers identify way to grow immune cells at large scale for preventing cancer reoccurrence

A class of proteins shown to be effective in reducing drug-seeking behaviors

UAB study shows how ion channel differentiates newborn and mature neurons in the brain

Scientists uncover mechanisms responsible for development of fibrosis

Ground-breaking discovery offers new hope for treatment of Alzheimer’s, other neurological diseases

Novel discovery offers hope for treatment of Alzheimer's and other neurological diseases

Silencing of GULP1 gene expression plays important role in ovarian carcinogenesis

Researchers find ways to render curcumin soluble and deliver it to infected tumors

Researchers develop 3D model of human placenta

Researchers discover key piece for slowing colorectal cancer subtype

Newly identified target may lead to discovery of treatments for chronic inflammatory diseases

New control system regulates morphology, orientation of cells constituting animal tissues

'Hijacked' cell response to stress reveals potential therapeutic targets for leukemia

Homogenous BTK occupancy assay used in tirabrutinib clinical studies

3D modeling of drug resistance could lead to more effective cancer treatment

Researchers describe key role of enzyme in regulating immune response against Chagas disease parasite

UM researchers awarded NIH funding to study bacterium that causes Lyme disease

Researchers elucidate role of mutations in deadly brain cancer

Study elucidates pathophysiology of systemic lupus erythematosus

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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