Signaling Pathway News and Research

RSS

Researchers find ATM protein that can trigger production of antioxidants

One reason we're supposed to eat a variety of colorful fruits and vegetables is because they contain nutritious compounds called antioxidants.

11 Jul 2018

Researchers discover mechanism that shuts down cell-to-cell communications pathway

Cellular functions rely on several communications networks that allow cells to rapidly respond to signals affecting the organism.

10 Jul 2018

U.S. researchers recommend development of anti-cancer drugs based on mechanism of Namodenoson

Can-Fite BioPharma Ltd., a biotechnology company advancing a pipeline of proprietary small molecule drugs that address cancer, liver and inflammatory diseases, today announced that U.S. researchers published scientific findings recommending development of anti-Liver Cancer Drugs based on a mechanism of action utilized by Namodenoson.

2 Jul 2018

Researchers find link between mutations in TRAF7 gene and multisystem disorder

A group of seven patients presenting with a similar disorder of unknown origin now know of a possible genetic root of their condition.

28 Jun 2018

Researchers show how mutant CALR protein triggers cancer

Researchers at Juntendo University report in the journal Leukemia how mutants of the protein calreticulin lead to molecular mechanisms triggering myeloproliferative neoplasms, which can cause cancer. The findings may lead to the development of novel therapies for certain types of blood cancer.

28 Jun 2018

Study links molecular changes in the brain to key behaviors in addiction

Changes in a brain signaling system contribute to the development of alcohol addiction-like behaviors in rats, according to a new study led by researchers at Linköping University, Sweden.

25 Jun 2018

New studies on molecular and cellular proteomics

Researchers at the Karolinska Institute were using a proteomic screen to determine the mechanism by which cancer drug candidates killed cells when they realized a potential flaw in the standard experimental design.

21 Jun 2018

Research sheds light on pathways involved in transmitting itch sensations from skin to brain

Researchers from North Carolina State University have pinpointed a particular neuropeptide associated with transmitting itch signals in mice with atopic dermatitis.

14 Jun 2018

Study opens new potential avenue for treating ovarian cancer

Researchers at Houston Methodist Research Institute and The University of Texas MD Anderson Cancer Center have found a prescription drug, Calcitriol, approved by the Food and Drug Administration for the treatment of calcium deficiency and kidney diseases, may increase the likelihood of surviving ovarian cancer.

14 Jun 2018

Study findings may lead to new approaches for treating inflammatory diseases

In the body, the immune system often begins its response to various attackers in the same way: the body activates immune cells, so-called phagocytes, which migrate to sites of inflammation caused by, for example, foreign pathogens or damaged tissue.

6 Jun 2018

Researchers discover how the heart becomes fully developed

Researchers have discovered how the heart develops from a simple tube into its characteristic S-shape and forms ventricles and atria.

4 Jun 2018

MDC researchers provide new insights on embryonic heart development

When it first starts to develop, the heart is a simple tube. Reporting in the journal Nature Communications, researchers at MDC have now described how it forms itself into a its characteristic S-shape and how the ventricles and atria finally develop.

4 Jun 2018

Detailed structure of protein pair offers blueprint for new medicines

Walter and Eliza Hall Institute researchers have visualized for the first time how the protein SOCS1 'switches off' cell signaling to dampen immune responses and block cancer growth.

4 Jun 2018

Researchers discover three genes that may have contributed to evolution of large human brain

Three genes involved in nerve cell generation in the brain emerged roughly 3.5 million years ago and may have contributed to the rapid evolution of the large human brain, Howard Hughes Medical Institute (HHMI) Investigator David Haussler and colleagues report on May 31, 2018, in the journal Cell.

1 Jun 2018

Scientists identify 'hidden' driver that helps prime the anti-tumor immune response

Like exposing a crime boss whose authority has gone undetected, St. Jude Children's Research Hospital scientists have identified a hidden driver that influences production of the T cells that fight cancer and infections. The study appears today as an advance online publication in the journal Nature.

31 May 2018

Mapping the Genes Responsible for Pluripotency

Dr. Atilgan Yilmaz and his team have developed a method by which they can produce haploid human embryonic stem cells from oocytes. They combined this technique with CRISPR-Cas9 to generate an atlas of the genome, containing the functions of over 18,000 genes.

23 May 2018