Angiotensin News and Research

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Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.

Conformational variation of the SARS-CoV-2 energy landscape

Researchers demonstrate that the energy landscape of SARS-CoV-2 exhibits significant conformational variation.

14 Mar 2022

Factors influencing cross-protective serological immunity against SARS-CoV-2 variants in Asians

Researchers assessed the impact of demographic variability on the Pfizer/BioNTech BNT162b2 vaccine-induced serological immunity against SARS-CoV-2 variants of concern and variants of interest.

14 Mar 2022

In silico screening of natural ACE2 inhibitors

Researchers identify potential ACE2 inhibitors through a virtual screening protocol.

14 Mar 2022

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Researchers screened 5,000 Food and Drug Association-approved drugs to identify repurposed drugs targeting SARS-CoV-2 spike protein cleavage at both S1/S2 boundary and S2’.

11 Mar 2022

Novel genetic relationships with severe SARS-CoV-2

Researchers discovered multiple novel genetic processes underpinning severe COVID-19 using genome-wide association studies and meta-analyses.

11 Mar 2022

Study suggests increased durability of immune responses towards SARS-CoV-2 spike protein after BNT62b2 booster

Researchers evaluated the immune responses after boosting with Pfizer's BNT162b2 vaccine.

11 Mar 2022

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Researchers evaluated the efficacy of viral spike domain 2-specific human monoclonal antibodies delivered intranasally, against all beta coronaviruses in hamsters and mice.

11 Mar 2022

Natural SARS-CoV-2 infection-induced anti-spike antibody responses

Researchers demonstrated the anti-spike antibody response to SARS-CoV-2 infection and further estimated the acute SARS-CoV-2 infection-induced Ab activity against recently emerged variants like Omicron.

10 Mar 2022

Cross-species infectivity of SARS-CoV-2 variants correlated with prevalence

New research discusses the role of mutations in the receptor-binding domain of the spike protein in the generation of antibody resistance and loss of vaccine efficacy.

10 Mar 2022

Study finds chimeric mRNA induces potent and broadly acting neutralizing antibodies against SARS-CoV-2 variants

Researchers explored strategies to develop an mRNA-based COVID-19 vaccine that could elicit safer and wider protection against SARS-CoV-2 variants of concern.

10 Mar 2022

Engineered SARS-CoV-2 immunogens elicit broadly neutralizing antibodies

New research describes a novel approach whereby SARS-2 antigens were analyzed for conserved sites that may be targeted by broadly neutralizing antibodies that will confer immunity to other Sarbecoviruses.

10 Mar 2022

Study isolated largest panel of β-CoV broadly neutralizing antibodies to date

Researchers isolated a large panel of broadly neutralizing antibodies from COVID-19 recovered-vaccinated donors.

10 Mar 2022

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

A new study used glycoprotein profiling technology platform that couples high-resolution LC-MS for glycoprotein analysis in regards to COVID-19.

9 Mar 2022

CRIPSR identifies cell-type-specific ACE2 modifiers

Researchers compile a list of candidate genes to identify the surface abundance of functional regulators of ACE2.

9 Mar 2022

Low SARS-CoV-2 diabetogenicity found in infected human pancreatic cells in vitro

Researchers assessed the diabetogenic potential of SARS-CoV-2 in a single cell in vitro analysis on the pancreatic islet cells.

9 Mar 2022

How will mutations change the SARS-CoV-2 spike protein in the future?

A new Cells review discusses the factors that affect the function of the SARS-CoV-2 S protein and provides theoretical limits of this viral protein.

8 Mar 2022

Study evaluates heterologous vaccination scheme in children using two SARS-CoV-2 RBD protein vaccines

A recent study predicted the efficacy of the SOBERANA 02 and SOBERANA Plus COVID-19 vaccines in children.

8 Mar 2022

A promising approach for COVID-19 prophylaxis

SARS-CoV-2 viruses can hide from recognition by the immune system. However, the antiviral immune receptor RIG-I can be stimulated, which improves protection against lethal SARS-CoV-2 infections.

8 Mar 2022

SARS-CoV-2 spike protein characteristics responsible for viral evolution in human hosts

Researchers directly compared the pre-fusion spikes of SARS-CoV-2 Alpha and Beta variants with the original Wuhan strain and the D614G-only variant.

8 Mar 2022

Omicron-based vaccine candidate generated to assess whether immunogenicity could be further improved

Researchers developed a vaccine candidate termed Ad26.COV2.S.529, encoding a stabilized Omicron-based S protein resembling ancestral SARS-CoV-2 Wuhan-Hu-1 S protein.

8 Mar 2022

Angiotensin News and Research

Further Reading

Conformational variation of the SARS-CoV-2 energy landscape

Factors influencing cross-protective serological immunity against SARS-CoV-2 variants in Asians

In silico screening of natural ACE2 inhibitors

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Novel genetic relationships with severe SARS-CoV-2

Study suggests increased durability of immune responses towards SARS-CoV-2 spike protein after BNT62b2 booster

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Natural SARS-CoV-2 infection-induced anti-spike antibody responses

Cross-species infectivity of SARS-CoV-2 variants correlated with prevalence

Study finds chimeric mRNA induces potent and broadly acting neutralizing antibodies against SARS-CoV-2 variants

Engineered SARS-CoV-2 immunogens elicit broadly neutralizing antibodies

Study isolated largest panel of β-CoV broadly neutralizing antibodies to date

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

CRIPSR identifies cell-type-specific ACE2 modifiers

Low SARS-CoV-2 diabetogenicity found in infected human pancreatic cells in vitro

How will mutations change the SARS-CoV-2 spike protein in the future?

Study evaluates heterologous vaccination scheme in children using two SARS-CoV-2 RBD protein vaccines

A promising approach for COVID-19 prophylaxis

SARS-CoV-2 spike protein characteristics responsible for viral evolution in human hosts

Omicron-based vaccine candidate generated to assess whether immunogenicity could be further improved

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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