Signaling Pathway News and Research

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Resistance training enhances cellular recycling in muscle cells

A new study has shown that resistance training among previously untrained men increases autophagosome content, but that this effect may be blunted by aging.

9 Apr 2018

Stable proteins in the brain offer clues to long-term memory and learning in mice

In the tiny brain space where two nerve cells meet, chemical and electric signals shuttle back and forth, a messaging system that ebbs and flows in those synaptic spaces, sometimes in ways that scientists believe aid and abet learning and memory.

3 Apr 2018

Combined treatment prolongs survival in mouse models of malignant mesothelioma

Combined treatment with two cancer immunotherapy drugs - one a novel immune modulator and one that focuses and activates the antitumor immune response - significantly prolonged survival in mouse models of the aggressive cancer malignant mesothelioma.

2 Apr 2018

Research reveals role of colon signaling pathway in development of IBD

The intestine encounters more foreign substances, and potential toxins, than other parts of the body, so it is not surprising that a healthy gut is maintained by the tight control of immune responses.

30 Mar 2018

Changing schedules of targeted therapy for melanoma could improve outcomes

Skin melanoma, a particularly insidious cancer, accounts for the vast majority skin cancer deaths and is one of the most common cancers in people under 30.

26 Mar 2018

Researchers make key discovery about cellular pathway linked to myriad of diseases

Researchers from the University of Dundee and the Francis Crick Institute have made a significant discovery about a cellular pathway associated with developmental defects and a myriad of diseases ranging from alopecia to colorectal cancer.

22 Mar 2018

Researchers propose alternative treatment to target lymphoma signaling at its root

Non-Hodgkin lymphomas are cancers that affect white blood cells of the immune system called B-lymphocytes or B cells. Like cells in all cancers, the B cells begin to grow out of control, creating tumors in the lymph nodes, spleen or other tissues. In 2010 alone, it was estimated that non-Hodgkin lymphomas caused 210,000 deaths worldwide.

22 Mar 2018

New DOD grant to support testing of promising therapy for triple-negative breast cancer

A unique cell surface protein found on triple-negative type breast cancer cells called JAG1 is a promising new therapeutic target for this hard-to-treat and highly metastatic type of breast cancer, according to researchers at the University of Illinois at Chicago.

21 Mar 2018

TSRI scientists discover new pathway to promote mitochondrial function during stress

Scientists at The Scripps Research Institute have discovered a new pathway in cells that promotes mitochondrial function during times of stress, a response that can guard against disease as we age.

15 Mar 2018

Golgi stress signaling pathway found in cells with Huntington’s disease

Working with cells grown in the lab, Johns Hopkins researchers have identified a biochemical pathway that allows a structure within cells, called the Golgi apparatus, to combat stress caused by free radicals and oxidants.

8 Mar 2018

Researchers discover novel mechanism that leads to pleural effusion in lung cancer patients

Lung cancer patients are particularly susceptible to malignant pleural effusion, when fluid collects in the space between the lungs and the chest wall.

1 Mar 2018

Study suggests novel approach for protecting diabetes patients from vascular disease

Recent findings suggest a novel approach for protecting people with diabetes from their higher risk of advanced blood vessel disease, which sets the stage for early heart attacks and strokes.

27 Feb 2018

Father's age can affect offspring lifespan, mice study shows

How does the father's age at conception affect his children? Researchers at the German Center for Neurodegenerative Disease and fellow scientists have studied this question in mice.

20 Feb 2018

Scientists suggest new strategy to inhibit untreatable, deadly nerve sheath tumors

Genomic profiling of mostly untreatable and deadly nerve sheath tumors led scientists to test a possible therapeutic strategy that inhibited tumor growth in lab tests on human tumor cells and mouse models, according to research in the journal Cancer Cell.

13 Feb 2018

Study adds more evidence that intestinal microbiome plays substantial role in obesity

A new Johns Hopkins study of mice with the rodent equivalent of metabolic syndrome has added to evidence that the intestinal microbiome -; a "garden" of bacterial, viral and fungal genes -; plays a substantial role in the development of obesity and insulin resistance in mammals, including humans.

6 Feb 2018

UIC scientists identify new chemical compound to stop bacteria from causing sickness

A study published in the Journal of Biological Chemistry is the first to describe a signaling pathway that affects communication -- a process called quorum sensing -- between Streptococcus bacteria cells.

6 Feb 2018

$Researchers develop novel method to aid fracture recovery$

Researchers develop novel method to aid fracture recovery

Researchers from Michigan Medicine have developed a novel method to aid the repair of difficult-to-heal fractures.

2 Feb 2018

Scientists identify new approach to enhance bone healing

When a patient breaks a bone, there's a possibility the fracture won't heal properly or quickly -- even with the aid of pins, plates or a cast.

1 Feb 2018

Research reveals why patients with diabetes have poorer prognosis for prostate cancer

Men with type 2 diabetes are less likely to develop prostate cancer than patients without diabetes. However, the mortality rate is higher.

31 Jan 2018

Metabolic shift can result in congestive heart failure

The heart derives its energy primarily from fatty acids. However, if a metabolic shift to other energy sources takes place, this can result in congestive heart failure, scientists from the German Cancer Research Center and Heidelberg University Hospital have now discovered.

23 Jan 2018