SARS CoV 2 News and Research

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Research uncovers SARS-CoV-2 viral traits critical for the virus in human airways

A new study published on the preprint server bioRxiv* in October 2020 reports the discovery of important viral genomic features that are crucial to its replication in the human airway cells, and its enhancing mutations which increase the rate of replication and determine its target cells.

26 Oct 2020

Small molecules block SARS-CoV-2 spike-ACE2 attachment

The search includes immunological agents, enzyme inhibitors, and soluble competitive inhibitors. Now, a new study published on the preprint server bioRxiv in October 2020 provides preliminary evidence that small molecules can inhibit viral entry by inhibiting spike-ACE2 attachment.

26 Oct 2020

COVID-19 now likely leading cause of death among 25-44's in USA

A team of researchers at Brigham and Women's Hospital, Department of Emergency Medicine, Harvard Medical School, aimed to determine changes in all-cause mortality or excess deaths among adults between 25 and 44 years old in the United States. Further, they also want to identify the years of lost life (YLL) among this age group.

26 Oct 2020

Population-based COVID-19 prevalence surveys in Europe and Americas show risk of bias

A team of researchers from the Federal University of Health Sciences of Porto Alegre and the Federal University of Rio Grande do Sul performed a systematic review to assess these population-based COVID-19 prevalence surveys' reliability and biases qualitatively. Their study is published on the preprint server medRxiv.

26 Oct 2020

Researchers present COVID RdRp structure at 2.5A

In a recent bioRxiv* preprint publication, Christopher J. Russo et al. report the structure of favipiravir ribonucleoside triphosphate (favipiravir-RTP) in complex with the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) bound to a template: primer RNA duplex. They determine the structure by electron cryomicroscopy (cryoEM) to a resolution of 2.5 Å.

26 Oct 2020

NRP-1 receptor potentiates SARS-CoV-2 infectivity

The COVID-19 pandemic is still actively spreading in many parts of the world, causing redoubled efforts to develop antivirals and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A recent study explores the role of a second type of cell surface receptor, called neuropilin, in the virus's entry into the host cell and its subsequent replication.

26 Oct 2020

New inhibitor of SARS-CoV-2 RNA translation

As the search for effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibitors continues, a recent study by Yale University School of Medicine researchers published on the preprint server bioRxiv in October 2020 reports the inhibitory effect of the drug merofloxacin on frameshifting during SARS-CoV-2 replication.

26 Oct 2020

Startling high SARS-CoV-2 seroprevalence in Veracruz, Mexico

A surprising new study published on the preprint server medRxiv in October 2020 reports a very high seroprevalence of IgG antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the city of Vera Cruz, Mexico. They are among the highest to be reported anywhere in the world.

25 Oct 2020

Graphene-enhanced PPE for COVID-19

To tackle this need, nanotechnology researchers from Italy have suggested using bidimensional graphene to improve existing PPE kits. Their research is published on the preprint server medRxiv.

25 Oct 2020

Tocilizumab fails to affect COVID-19 disease outcomes in Boston trial

Researchers from the various Massachusetts hospitals performed the Boston Area COVID-19 Consortium (BACC) Bay Tocilizumab Trial using tocilizumab administered early in the disease course to determine if early IL-6 receptor blockade limits progression of COVID-19 to hypoxemic respiratory failure or death. Their work is published in the prestigious New England Journal of Medicine.

25 Oct 2020

Neuropilin-1: A new route of SARS-CoV-2 entry

A new study published in the reputed journal Science in October 2020 reports the potential therapeutic value of the second type of host transmembrane receptor, called neuropilins, which attach to the spike protein of SARS-CoV-2 and may enhance its infectivity.

25 Oct 2020

Air pollution increases SARS-CoV-2 transmission

Evidence from China indicates that higher air pollution could lead to increased transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leading to more COVID-19 cases.

25 Oct 2020

COVID-19 incubation period potentially much longer than previously thought

Researchers at Trinity College Dublin have provided an updated estimate of the incubation period for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent causes coronavirus disease 2019 (COVID-19).

25 Oct 2020

Universal testing in schools may be needed to prevent SARS-CoV-2 transmission

Researchers at Simon Fraser University in Canada have warned that within the school setting, even small differences in individuals' contribution, their environment, and their activities to the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) result in highly variable sizes of transmission clusters.

25 Oct 2020

Scientists devise new method to map HIV's sugary shield in unprecedented detail

Scientists from Scripps Research and Los Alamos National Laboratory have devised a method for mapping in unprecedented detail the thickets of slippery sugar molecules that help shield HIV from the immune system.

23 Oct 2020

Mathematical modeling study offers new insights into optimal timing of antiviral therapies against COVID-19

A new mathematical modeling study by Ashish Goyal and colleagues, informed by data collected from 25 patients hospitalized with COVID-19 in 4 different countries, offers some important new insights into the optimal timing of 4 different antiviral therapies to combat the disease.

23 Oct 2020

Researchers identify molecular processes in kidney cells that attract and feed COVID-19

Although the lungs are a common target for COVID-19's cytokine storm, so are the kidneys, making the 1 in 4 U.S. adults with diabetes resulting in diabetic kidney disease at increased risk for virus mortality.

23 Oct 2020

Molecular processes in kidney cells may increase diabetics' vulnerability to COVID-19 infection

People with diabetes -- especially the 20 to 40 percent with diabetic kidney disease -- are among the most at risk for serious complications and death from COVID-19.

23 Oct 2020

Study: 90% of patients have detectable antibodies up to 7 months post contracting COVID-19

A new study led by Marc Veldhoen, principal investigator at Instituto de Medicina Molecular João Lobo Antunes (iMM; Portugal) with an interdisciplinary team of clinicians and researchers from Faculdade de Medicina da Universidade de Lisboa (FMUL) and Centro Hospitalar Lisboa Norte (CHLN) and collaborators at Instituto Português do Sangue e Transplantação (IPST), shows that 90% of subjects have detectable antibodies 40 days up to 7 months post contracting COVID-19.

23 Oct 2020

HU laboratories develop novel treatment methods and technology to fight against COVID-19

A couple of days before October, the world hit another bleak milestone as the number of deaths due to COVID-19 reached one million.

23 Oct 2020

SARS CoV 2 News and Research

Research uncovers SARS-CoV-2 viral traits critical for the virus in human airways

Small molecules block SARS-CoV-2 spike-ACE2 attachment

COVID-19 now likely leading cause of death among 25-44's in USA

Population-based COVID-19 prevalence surveys in Europe and Americas show risk of bias

Researchers present COVID RdRp structure at 2.5A

NRP-1 receptor potentiates SARS-CoV-2 infectivity

New inhibitor of SARS-CoV-2 RNA translation

Startling high SARS-CoV-2 seroprevalence in Veracruz, Mexico

Graphene-enhanced PPE for COVID-19

Tocilizumab fails to affect COVID-19 disease outcomes in Boston trial

Neuropilin-1: A new route of SARS-CoV-2 entry

Air pollution increases SARS-CoV-2 transmission

COVID-19 incubation period potentially much longer than previously thought

Universal testing in schools may be needed to prevent SARS-CoV-2 transmission

Scientists devise new method to map HIV's sugary shield in unprecedented detail

Mathematical modeling study offers new insights into optimal timing of antiviral therapies against COVID-19

Researchers identify molecular processes in kidney cells that attract and feed COVID-19

Molecular processes in kidney cells may increase diabetics' vulnerability to COVID-19 infection

Study: 90% of patients have detectable antibodies up to 7 months post contracting COVID-19

HU laboratories develop novel treatment methods and technology to fight against COVID-19

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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