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Researchers discover molecular signature to predict TB infection

Dallas scientists recently discovered a molecular signature in the blood of patients with tuberculosis (TB) that may explain why some people develop an active TB infection, while others exposed to the bacteria which causes the dangerous respiratory virus do not.

24 Sep 2010

Breast cancer incidence drops, linked to decline in HRT use

A new Canadian study shows that a significant drop in breast cancer incidence among post-menopausal women from 2002 to 2004 coincided with a sharp drop in hormone replacement therapy (HRT) use during the same period. This is the first study to show the link between HRT use and breast cancer among Canadian women.

24 Sep 2010

Researchers report MALAT1 gene regulates pre-mRNA splicing in cancer

Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing a critical step in the earliest stage of protein production. Their study appears in the journal Molecular Cell.

24 Sep 2010

Biothera receives SBIR award to evaluate therapeutic potential of Imprime PGG drug in pancreatic cancer

Biothera has received a National Cancer Institute SBIR award to evaluate the therapeutic potential of its drug candidate Imprime PGG in pancreatic cancer, the company announced today.

24 Sep 2010

Antipsychotics slightly raise risk for blood clots

Antipsychotics or medications that are used to treat psychiatric illnesses such as schizophrenia and bipolar disorder are reported to raise the risk of dangerous blood clots.

23 Sep 2010

Gersak develops Convergent Procedure for atrial fibrillation

During the recent Atrial Fibrillation Session of the Techno College at the European Association of Cardiac Thoracic Surgeons in Geneva, Switzerland, Professor Borut Gersak, Head of Cardiac Surgery from University Medical Center in Ljubljana, Slovenia challenged his audience of more than 1,000 medical professionals to think differently about existing atrial fibrillation surgical approaches.

23 Sep 2010

NCI selects Caliper's Quantum FX microCT system to study tumor models in lung cancer

Caliper Life Sciences, Inc., a leading provider of tools and services for drug discovery and life sciences research, today announced that the National Cancer Institute has purchased Caliper's Quantum FX, a stand-alone microCT system for pre-clinical imaging, to study spontaneous tumor models in lung cancer.

23 Sep 2010

Implantation of new bioprosthetic-tissue valve in patients with severe aortic stenosis saves lives

Implantation of a new bioprosthetic-tissue valve into the hearts of patients who have severe aortic stenosis and are too sick or too old for open-heart surgery has been found to both save lives and improve the quality of those lives, according to a new multicenter study, to be published online at 2 p.m. Pacific time today in the New England Journal of Medicine.

23 Sep 2010

FDA and EMA accept regulatory submissions of vandetanib for advanced medullary thyroid cancer

AstraZeneca today announced that the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have accepted regulatory submissions for review of the investigational drug vandetanib in the treatment of patients with advanced medullary thyroid cancer (MTC). The FDA also granted priority review status for the new drug application and set a Prescription Drug User Fee Act (PDUFA) action date of 7 January 2011.

23 Sep 2010

High selenium intake associated with lower rates of bladder cancer in women

Scientists in Spain have found that adding a can of tuna or other fish to our shopping lists could help protect us against bladder cancer.

23 Sep 2010

Cardiovascular Innovation Institute awarded NIH grant to develop implantable pump for single ventricle heart disease

Researchers in the Cardiovascular Innovation Institute, a partnership between the University of Louisville and Jewish Hospital, in collaboration with researchers at Indiana University and Purdue University, have received a $2,027,059 grant from the National Institutes of Health to further develop an implantable pump that could dramatically improve the lives of patients with single ventricle heart disease.

23 Sep 2010

Researchers develop drug to eliminate disease transmission by cough

What if there was a drug that could completely eliminate airborne disease transmission that occurs when someone coughs. Researchers at the University of Alberta believe they have found a way to achieve this.

23 Sep 2010

U.S. joins whistleblower suit against Pfizer for drug marketing

The Wall Street Journal: "The Justice Department is trying to take the lead in a lawsuit accusing Pfizer Inc.'s Wyeth unit of improperly promoting an organ-transplant drug for unauthorized uses and paying illegal kickbacks to doctors. The lawsuit was filed by two former Wyeth sales representatives who were responsible for promoting Rapamune, an immunosuppressant used to prevent the body's rejection of transplanted kidneys.

23 Sep 2010

AstraZeneca to use THEW database for cardiac safety evaluation

AstraZeneca purchased a one-year membership to gain access to an international repository of data designed to aid industry and academic researchers developing new technologies to improve cardiac safety.

23 Sep 2010

Scientists develop new therapy for treatment of skin, lung cancer

Scientists at the University of Granada have developed a new therapy for the treatment of skin and lung cancer. This therapy involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.. Their studies have demostrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

22 Sep 2010

Protein zyxin necessary for maintenance and repair of cell's cytoskeleton

Researchers at Huntsman Cancer Institute (HCI) at the University of Utah have discovered that a protein, zyxin, is necessary for the maintenance and repair of the cell's cytoskeleton, or internal framework, which serves as the muscle and bone of the cell. The research has implications for cancer, as well as other diseases, since alterations in the cytoskeleton are often associated with disease. The research was published in the Sep. 14, 2010, issue of the journal Developmental Cell.

22 Sep 2010

UT MD Anderson Cancer Center aims to reduce tobacco use among at-risk youths in SE Texas

The University of Texas MD Anderson Cancer Center is reaching out to southeast Texas via an interactive, arcade-style video game aimed at reducing tobacco use among at-risk teens and adolescents.

22 Sep 2010

AACR to host fourth International Conference on Molecular Diagnostics

The American Association for Cancer Research will host its Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development from Sept. 27-30, 2010, at the Sheraton Denver Downtown in Denver, Colo.

22 Sep 2010

JHS conference focuses on future research directions to eliminate health disparities

The tenth anniversary of the Jackson Heart Study (JHS) will be observed on Sept. 23-24 in Jackson, Mississippi. The JHS is the largest study in history to investigate genetic factors that affect high blood pressure, heart and lung disease, stroke, diabetes, and other important diseases in African-Americans.

22 Sep 2010

Synthetic lethality boosts effectiveness of molecularly targeted therapies against tumors

Molecularly targeted therapies can reduce tumors rapidly. However, not all tumors respond to the drugs, and even those that do often develop resistance over time. Looking for a way to combat the problem of resistance, researchers at Fox Chase Cancer Center hypothesized that hitting already weakened cancer cells with a second targeted agent could kill them-but only if it was the right second agent.

22 Sep 2010

Lungs News and Research

Researchers discover molecular signature to predict TB infection

Breast cancer incidence drops, linked to decline in HRT use

Researchers report MALAT1 gene regulates pre-mRNA splicing in cancer

Biothera receives SBIR award to evaluate therapeutic potential of Imprime PGG drug in pancreatic cancer

Antipsychotics slightly raise risk for blood clots

Gersak develops Convergent Procedure for atrial fibrillation

NCI selects Caliper's Quantum FX microCT system to study tumor models in lung cancer

Implantation of new bioprosthetic-tissue valve in patients with severe aortic stenosis saves lives

FDA and EMA accept regulatory submissions of vandetanib for advanced medullary thyroid cancer

High selenium intake associated with lower rates of bladder cancer in women

Cardiovascular Innovation Institute awarded NIH grant to develop implantable pump for single ventricle heart disease

Researchers develop drug to eliminate disease transmission by cough

U.S. joins whistleblower suit against Pfizer for drug marketing

AstraZeneca to use THEW database for cardiac safety evaluation

Scientists develop new therapy for treatment of skin, lung cancer

Protein zyxin necessary for maintenance and repair of cell's cytoskeleton

UT MD Anderson Cancer Center aims to reduce tobacco use among at-risk youths in SE Texas

AACR to host fourth International Conference on Molecular Diagnostics

JHS conference focuses on future research directions to eliminate health disparities

Synthetic lethality boosts effectiveness of molecularly targeted therapies against tumors

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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