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Researchers use new technology to reveal different genetic patterns of neuroblastoma

Researchers at the Sahlgrenska Academy at the University of Gothenburg, Sweden and Karolinska Institutet have used novel technology to reveal the different genetic patterns of neuroblastoma, an aggressive form of childhood cancer. This discovery may lead to significant advances in the treatment of this malignant disease, which mainly affects small children.

22 Feb 2010

New gene locus influencing risk for atrial fibrillation identified

Atrial fibrillation is a cardiac arrhythmia - a chronic irregularity of heartbeat - which affects an estimated 1 million people in Germany. Although the condition is not acutely life-threatening, it does increase the risk of developing more serious illnesses, such as cardiac insufficiency, stroke and dementia. In the third of a series of genomewide asssociation studies, an international team of researchers, led by LMU physician PD Dr. Stefan K--b, now reports the identification of a new gene locus that has a significant influence on risk for atrial fibrillation.

22 Feb 2010

Researchers identify common gene variant associated with atrial fibrillation

An international research team has identified a common gene variant associated with a form of the irregular heartbeat called atrial fibrillation. In their report in the journal Nature Genetics, being published online, the investigators describe finding that variations affecting a protein that may help control the heart's electrical activity appear to increase the risk of what is called lone atrial fibrillation (AF), a type seen in younger individuals with no other form of heart disease.

22 Feb 2010

Children born through assisted reproduction at greater risk of obesity and type 2 diabetes related defects

More than three million children have been born as a result of assisted reproductive technologies since the birth of the first "test tube baby" in 1978. While the majority of these children are healthy and normal, as a group they are at greater risk of certain kinds of birth defects and being low birth weight, which is associated with obesity, hypertension and type 2 diabetes later in life.

22 Feb 2010

Scientists develop new mathematical model to understand CML better

Doctors can now understand better chronic myeloid leukaemia (CML), including how it responds to therapy, thanks to a new mathematical model for the disease, developed by scientists in Portugal, Belgium and the United States. The work, to be published in the June edition of the journal Haematologica, also reveals that current therapies - which are not believed to cure CML - with the right protocol can actually get rid of the disease, and provides guidelines on how to do that.

21 Feb 2010

Cancer genomes: Distinguishing between 'driver' and 'passenger' mutations

A new study of mutations in cancer genomes shows how researchers can begin to distinguish the 'driver' mutations that push cells towards cancer from the 'passenger' mutations that are a by-product of cancer cell development. The study also shows that at least one in nine genes can be removed without killing human cells.

19 Feb 2010

Most genetic abnormalities shared across multiple cancers

An international team of researchers has created a genome-scale map of 26 different cancers, revealing more than 100 genomic sites where DNA from tumors is either missing or abnormally duplicated compared to normal tissues. The study, the largest of its kind, finds that most of these genetic abnormalities are not unique to one form of cancer, but are shared across multiple cancers. The work appears in the February 18 issue of the journal Nature.

19 Feb 2010

Study analyzes genome and exome sequence data from hunter-gatherer participants of South Africa

In a study published online today in Nature, a team of researchers from Penn State University and the University New South Wales present the complete genome sequences of an indigenous hunter-gatherer from the Kalahari Desert and a Bantu from southern Africa, along with three additional whole exome sequences of Kalahari hunter-gatherers.

19 Feb 2010

Novartis' Tasigna capsules granted priority review by FDA for treatment of adult patients with Ph+ CML

Novartis announced today that Tasigna® (nilotinib) 200 mg capsules has been granted priority review by the US Food and Drug Administration for the treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase.

19 Feb 2010

Johns Hopkins Kimmel Cancer Center scientists develop genome-based blood tests for cancer

Scientists at the Johns Hopkins Kimmel Cancer Center have used data from the whole genome sequencing of cancer patients to develop individualized blood tests they believe can help physicians tailor patients' treatments. The genome-based blood tests, believed to be the first of their kind, may be used to monitor tumor levels after therapy and determine cancer recurrence.

19 Feb 2010

Researchers have traced protein that stops cells from becoming cancerous

In the dominoes that make up human cells, researchers at the University of Michigan Comprehensive Cancer Center have traced another step of the process that stops cells from becoming cancerous.

17 Feb 2010

Researchers find new risk factor for early-onset dementia

Examining brain tissue from over 500 individuals in 11 countries, researchers from the University of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia, and colleagues found a new risk factor for the second-most-common cause of early-onset dementia after Alzheimer's disease.

16 Feb 2010

New research finds sensory cortex develops late in fragile X syndrome defect

Why do people with fragile X syndrome, a genetic defect that is the best-known cause of autism and inherited mental retardation, recoil from hugs and physical touch - even from their parents?

12 Feb 2010

Scientists uncover new gene that could help save sight of patients with inherited blindness

The international research team led by the University of Leeds found that the TSPAN12 gene is faulty in patients with a disease known as FEVR (Familial Exudative Vitreoretinopathy), which affects the development of the eye.

12 Feb 2010

4SC AG announces the first treatment in Phase I clinical study of 4SC-205

4SC AG a drug discovery and development company focused on autoimmune and cancer indications, today announced the first treatment in a Phase I study evaluating 4SC-205, an oral Eg5 kinesin spindle protein inhibitor, in patients with solid tumours or malignant lymphomas.

11 Feb 2010

Study shows cellular circuitry is more complex than previously thought

Using an elaborate sleuthing system they developed to probe how cells manage their own division, Johns Hopkins scientists have discovered that common but hard-to-see sugar switches are partly in control.

6 Feb 2010

Results validating performance of GSN’s proprietary Parental Support technology published

Gene Security Network, Inc (GSN) today announced that Human Reproduction published results validating the exceptional performance of GSN’s proprietary Parental SupportTM technology over existing methods to detect chromosome abnormalities during in vitro-fertilization (IVF).

5 Feb 2010

Defective chromosome cause of severe obesity

A new cause of obesity due to a defect on chromosome 16 has just been discovered. It is thought to explain close to 1% of obesity cases. For carriers of the defect, the risk of becoming overweight is 50 times higher. This research is the result of close cooperation between the team of Professor Froguel, a CNRS researcher, in Lille, and colleagues at Imperial College in London and Vaudois University Hospital in Lausanne, with the support of ten other European research groups. The findings of the study are to be published in Nature on February 4, 2010.

4 Feb 2010

New research shows tumor suppressor p53 prevents cancer progression in cells

Cells missegregate a chromosome approximately once every hundred divisions. But don't be too alarmed: new research in the Journal of Cell Biology shows that the tumor suppressor p53 limits the growth of cells with incorrect numbers of chromosomes and prevents their progression toward cancer.

2 Feb 2010

GSA announces recipients of 2010 awards for distinguished service in the field of genetics

The Genetics Society of America (GSA) is pleased to announce the recipients of its five awards for distinguished service to the field of genetics. These awards represent sustained activity and contributions by members of the genetics community.

29 Jan 2010

X chromosome News and Research

Researchers use new technology to reveal different genetic patterns of neuroblastoma

New gene locus influencing risk for atrial fibrillation identified

Researchers identify common gene variant associated with atrial fibrillation

Children born through assisted reproduction at greater risk of obesity and type 2 diabetes related defects

Scientists develop new mathematical model to understand CML better

Cancer genomes: Distinguishing between 'driver' and 'passenger' mutations

Most genetic abnormalities shared across multiple cancers

Study analyzes genome and exome sequence data from hunter-gatherer participants of South Africa

Novartis' Tasigna capsules granted priority review by FDA for treatment of adult patients with Ph+ CML

Johns Hopkins Kimmel Cancer Center scientists develop genome-based blood tests for cancer

Researchers have traced protein that stops cells from becoming cancerous

Researchers find new risk factor for early-onset dementia

New research finds sensory cortex develops late in fragile X syndrome defect

Scientists uncover new gene that could help save sight of patients with inherited blindness

4SC AG announces the first treatment in Phase I clinical study of 4SC-205

Study shows cellular circuitry is more complex than previously thought

Results validating performance of GSN’s proprietary Parental Support technology published

Defective chromosome cause of severe obesity

New research shows tumor suppressor p53 prevents cancer progression in cells

GSA announces recipients of 2010 awards for distinguished service in the field of genetics

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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