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The latest endocrinology news from News Medical |
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 | | |  Do GLP-1 drugs cause cancer? New review says no, may even protect A comprehensive review in The Journal of Clinical Investigation finds no overall link between GLP-1 receptor agonists and increased cancer risk, countering early safety concerns. Instead, evidence suggests possible protective effects for certain cancers, supported by metabolic and immune-modulating mechanisms. | | | | |  Research shows citrus and grape compounds may protect against type 2 diabetes A six-month clinical trial found that a supplement combining citrus and grape extracts, hesperidin, and chromium significantly reduced fasting blood glucose in prediabetic adults. Participants also saw improved cholesterol and triglyceride levels, returning many to normal metabolic health. | |
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|  | | | | |  Does fasting earlier in the day improve metabolism? This study says no In a randomized crossover trial of 31 women with overweight, early and late time-restricted eating (TRE) produced no improvement in insulin sensitivity or cardiometabolic markers under isocaloric conditions. Both schedules, however, shifted internal circadian clocks, highlighting that meal timing affects biological rhythms more than metabolic outcomes. | |  | | | | |  GLP-1 drugs calm inflammation beyond diabetes and weight loss This Journal of Clinical Investigation review describes how glucagon-like peptide-1 (GLP-1)–based medicines reduce systemic and tissue inflammation through both weight-dependent and weight-independent mechanisms. It details preclinical and clinical evidence linking GLP-1 receptor activation to cardiovascular, renal, hepatic, neural, and joint anti-inflammatory effects while outlining uncertainties and future research needs. | | | | | | |  How gut microbes shape sleep: New review reveals microbiome clues to insomnia and apnea A new Brain Medicine review maps how gut microbes influence sleep disorders, from insomnia and sleep apnea to circadian disruption, via bile acids, neurotransmitters, and immune pathways. The findings highlight gut-driven targets for improving sleep quality through diet, probiotics, and microbiome modulation. | |
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| | | |  Running may help burn calories, but when it comes to preventing diabetes and obesity, pumping iron might have the edge, according to preclinical findings from the Fralin Biomedical Research Institute at VTC. | | | | |  Pancreatic cancer is notoriously hard to treat and often resists the most advanced immunotherapies. Northwestern Medicine scientists have uncovered a novel explanation for that resistance: Pancreatic tumors use a sugar-based disguise to hide from the immune system. | | | | |  Contrary to previous research, transgender women who use the hormone oestradiol for their transition do not have an increased risk of heart attack and stroke compared to men in the general Dutch population. | | | | |  People with type 1 diabetes achieved significantly better long-term blood glucose when their levels were monitored by healthcare professionals in real time, via a sensor under the skin, and they received regular advice in their daily lives. | | | | |  Sharing happy moments with a partner may be good for older people's health, lowering the level of the stress hormone cortisol in their bodies, according to research published by the American Psychological Association. | | | | |  Using targeted radiation during surgery - referred to as intraoperative radiation - to eliminate pancreatic cancer cells that have spread to areas around the pancreas, investigators at Johns Hopkins have been able to reduce the recurrence rate around the pancreas to 5%. | | | | |  A comprehensive review published today in Brain Medicine illuminates the intricate connections between gut microbiota and sleep regulation, establishing the microbiota-gut-brain axis as a critical pathway in understanding and potentially treating sleep disorders. | | | | |  What if the brain's response to stress could be read not in fleeting neurotransmitter bursts, but in the quieting of genes deep inside chromatin? Researchers at the University of Alabama at Birmingham have now shown that stress hormones may silence crucial neuronal genes through an unexpected class of RNA molecules that operate not by encoding proteins, but by reshaping the genome's architecture. | | | | |  A poorly characterized protein, historically thought to be a chaperone or enzyme, may actually be a key player in prostate cancer. | |
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