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The latest endocrinology news from News Medical |
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 | | |  Study finds GLP-1 medicines cut fat while preserving muscle function Researchers found that GLP-1 medicines caused weight loss mainly through fat reduction, with only modest decreases in absolute muscle mass and no disproportionate loss of muscle function. In mice, physical performance improved, while in a small 12-week human pilot trial, strength was preserved despite reduced thigh muscle size. | | | | |  Menopause may raise women’s Alzheimer risk earlier than doctors once thought This review argues that women’s higher Alzheimer disease risk may be shaped in part by midlife neuroendocrine aging, especially the menopause transition, rather than by longevity alone. It highlights early menopause, bilateral oophorectomy, vasomotor symptoms, and midlife cognitive changes as underinvestigated but potentially important risk markers, while calling for sex-specific, biomarker-driven prevention strategies. | |
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|  | | | | |  How one antibiotic dose can reshape your gut microbiome for years Long-term registry-linked analysis of nearly 15,000 adults shows that antibiotic use is associated with persistent changes in gut microbiome diversity and composition for up to 4–8 years. These effects vary by antibiotic class, with clindamycin, fluoroquinolones, and flucloxacillin showing the strongest and most sustained associations. | |  | | | | |  GLP-1 drugs cut heart and kidney risks in type 1 diabetes study In a large target trial emulation of 174,678 people with type 1 diabetes, GLP-1 receptor agonist initiation was associated with lower risks of major cardiovascular events and end-stage kidney disease over five years. The study also found no increased risk of hospitalization for diabetic ketoacidosis or severe hypoglycemia, supporting further randomized trials of GLP-1RAs as adjunctive therapy in type 1 diabetes. | | | | | | |  Researchers show how smartwatches can help identify insulin resistance Researchers developed a scalable framework that predicts insulin resistance using wearable-device signals, routine blood biomarkers, and demographic data, with stronger performance when these data streams were combined. The study also introduced an AI agent to explain insulin resistance risk, interpret results, and support earlier metabolic risk screening. | |
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| | | |  Continuous use of GLP-1 receptor agonists in adults with type 2 diabetes was associated with a lower risk of major cardiovascular events compared with sulfonylureas, with benefits increasing over time. Discontinuation or interruption was associated with a progressive loss of this protective effect, with risks approaching those of comparator therapy. | | | | |  For women age 70 and over with a common form of breast cancer, determining "the right size" of treatment can be challenging, in part because clinicians have limited tools to guide individualized treatment decisions. | | | | |  A new preclinical study shows that red blood cells can be tagged in vivo and used as long-lasting carriers for imaging agents and therapies, opening a new route for safer drug delivery and vascular imaging. | | | | |  Losing health insurance can quickly worsen health for people with diabetes as patients struggle to control the disease after coverage is interrupted, according to new research from Oregon Health & Science University, | | | | |  Minimally cooked potatoes may reduce blood sugar spikes, but benefits are short-lived and specific to certain populations, as shown in recent research. | | | | |  Adolescents who replaced just half an hour of sedentary behaviors, such as sitting on the couch or spending time at the computer, each day for moderate-to-vigorous physical activity or sleep may lower their insulin resistance, a key factor in preventing the development of Type 2 diabetes, according to preliminary research presented at the American Heart Association's EPI|Lifestyle Scientific Sessions 2026. | | | | |  Advancements in pharmacogenomics and multi-omics are transforming IBS care, enabling personalized treatment strategies based on genetic and microbiome insights. | | | | |  Researchers used a bioinformatics-plus-rat-model approach to investigate how palmatine may help treat T2DM-associated MASLD, identifying five core targets: ADRB2, BCL3, EGR1, FOS, and MAP3K8. In rats, palmatine improved liver injury, inflammation, oxidative stress, glycolipid metabolism, steatosis, and fibrosis, while reducing apoptosis-related signaling, providing a preclinical foundation for further therapeutic study. | | | | |  The American Psychological Association describes seven distinct types of rest that address different forms of fatigue experienced in daily life. | | | | |  Proteomic profiling captures real-time protein changes, offering insights into metabolic health, immune responses, and the aging process for personalized care. | |
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