|
|
|
| |
|
|
| |
The latest endocrinology news from News Medical |
|
|
|
|  | | | | |  New drug could double survival time in patients with advanced pancreatic cancer A new medication could double survival time in patients with advanced pancreatic cancer, according to Phase III clinical trial results presented at the American Society of Clinical Oncology (ASCO) 2026 annual meeting and simultaneously published in The New England Journal of Medicine. | |  | | | | |  Tirzepatide activates calorie-burning brown fat to combat obesity Tirzepatide doesn't just help people lose weight; it also activates brown adipose tissue, representing a major milestone in obesity research, according to a study being presented Monday at ENDO 2026, the Endocrine Society's annual meeting in Chicago, Ill. | | | | | | |  Study identifies top predictors for weight loss using tirzepatide One of the largest real-world studies of people taking GLP-1 medications found women, those without pre-existing conditions such as type 2 diabetes and high blood pressure, and behavioral factors such as previously setting a weight goal were the best predictors of total weight loss, according to a study being presented Monday at ENDO 2026, the Endocrine Society's annual meeting in Chicago, Ill. | |
|
|
|  | | |  A new paper led by researchers at University of Victoria's Canadian Institute for Substance Use Research (CISUR) contributes to mounting evidence that alcohol use can cause pancreatic cancer. | | | | |  MIRA, an autonomous AI agent tested in a sandboxed electronic health record, diagnosed 574 real emergency department cases with 88.9% accuracy and outperformed physicians in a matched 311-case comparison. The system ordered tests, generated medication plans, and made admission decisions in simulation, but the authors stress that prospective validation, governance, and physician oversight are still essential. | | | | |  Researchers from the University of Kansas have shown a link between reproductive hormone exposure throughout life and brain health in 459 women aged 65 to 80. | | | | |  Consider what we ask of a clinical trial. We gather people who differ in nearly every way that matters, we give them the same drug at the same dose, and then we average the result and call the average truth. | | | | |  A new Review reveals how aging can push the immune system into a paradoxical state, weaker against threats yet more prone to attacking the body’s own tissues. | | | | |  A new review reframes PCOS, now proposed as PMOS, as a systemic endocrine and metabolic disorder shaped by genetic, epigenetic, ovarian, metabolic, and neuroendocrine pathways. It highlights why inconsistent diagnosis and symptom-focused care have limited progress, while targeted therapies, biomarkers, machine learning, and organ-on-chip models may support more personalized treatment. | | | | |  The body's organs are in constant communication. Fat tissue tells the liver when to store or release energy, the immune system signals localized inflammation, and thousands of proteins carry these messages to organs throughout the body. | | | | |  This review describes how gut microbial messengers, including SCFAs, microbiota-modified bile acids, neuroactive metabolites, and extracellular vesicles, may shape obesity and type 2 diabetes through the microbiota-gut-brain axis. | | | | |  Research suggests blueberry compounds could enhance mood and cognitive function in children, yet stronger evidence is required for clinical recommendations. | | | | |  A systematic review identified 41 human studies evaluating interventions targeting next-generation DNA methylation-based aging clocks. Pharmaceutical, lifestyle, supplement, clinical, and psychosocial interventions shifted some clock outputs, but these biomarkers remain investigational rather than proven clinical surrogates. | | | | |  Researchers created a DIA-MS atlas of 13,609 proteins across 2,856 samples from fetal, healthy adult, paired non-tumor, and tumor tissues. The resource maps tissue-specific protein patterns, cancer-associated changes, organ-specific drug-toxicity signals, and candidate therapeutic targets. | | | | |  Higher serum 25-hydroxyvitamin D levels were independently associated with lower LDL-C, triglycerides, and lipoprotein(a) in 773 male professional athletes. The cross-sectional study cannot establish causality, but it suggests that vitamin D status may be linked to cardiovascular risk-related lipid markers, even in elite athletic populations. | | | | |  A large plasma proteomics study shows that aging patterns in specific cell types may help identify who is more vulnerable to disease and who is more resilient. Study: Plasma proteomic signatures of cellular aging predict human disease. | | | | |  Following semaglutide's approval, poison center reports of GLP-1 RA exposures doubled, revealing critical trends in patient safety and healthcare utilization. | | | | |  Research indicates that hormonal therapies and later menopause are associated with increased brain volume and thickness, promoting healthier aging. | |
|
|
|
|
|
|
|
