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The latest endocrinology news from News Medical |
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 | | |  Genetic analysis of 1 million people points to FNIP1 as a promising metabolic target Mega-scale exome sequencing of 1,032,116 people identified 59 independent genes linked to the TG:HDL ratio, including 44 rare-coding associations not detected in the previous largest analysis. Ultra-rare FNIP1 loss-of-function variants were associated with favorable fat distribution, lower liver fat and glycemia, and around 60% lower odds of a composite cardiometabolic disease outcome. | | | | |  Semaglutide slows blood protein signature linked to future dementia risk A post hoc analysis of 2,970 older SELECT participants found that semaglutide slowed worsening of a 25-protein blood signature that predicts future dementia risk. Over 104 weeks, semaglutide produced larger effects on modeled 5-year than 20-year dementia risk, but whether these biomarker changes translate into less cognitive decline or dementia remains unknown. | |
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| | | | |  Researchers at McMaster University have discovered that a naturally occurring hormone best known for suppressing appetite and promoting weight loss also helps protect the liver from inflammation through a previously unknown signalling pathway, opening new possibilities for treating advanced fatty liver disease. | | | | |  A University of Oklahoma researcher has received a five-year, $2 million grant from the National Cancer Institute to investigate how pancreatic cancer uses cholesterol to survive chemotherapy. | | | | |  The type of menopause symptoms, as well as their severity, can differ greatly among women. A number of earlier studies have suggested various reasons for those differences. | | | | |  A single 25-mg dose of psilocybin with psychological support was feasible to deliver within an NHS setting and produced large preliminary reductions in depressive symptoms among adults with treatment-resistant depression. The Phase 2 feasibility trial also found the treatment was generally well tolerated, although functional unblinding and expectancy effects mean larger, longer efficacy studies are needed. | | | | |  A new study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center found that while traditional pathological features used to classify aggressive prostate cancer -such as high-grade disease, cancer extending outside the prostate and cancer involving the seminal vesicles- after surgery can help identify patients who are more likely to have worse outcomes, they do not predict who will benefit more from adding hormone therapy to... | | | | |  According to a study conducted in Brazil by researchers at the Federal University of São Paulo (UNIFESP) with participants from the São Paulo Epidemiological Sleep Study (EPISONO 2018), people with hypothyroidism experience a higher frequency and severity of obstructive sleep apnea (OSA). | | | | |  Phthalates, which are chemicals found in plastics, personal care products and hundreds of other consumer goods, may contribute to high blood pressure in pregnant women, according to a study published in the Journal of the Endocrine Society. | | | | |  In a randomized study of 109 young adults, researchers measured cortisol responses, skin conductance signals, and risk-taking during the Iowa Gambling Task after an acute psychosocial stressor. Cortisol reactivity altered how anticipatory bodily signals related to risky choices in men, although the stress condition did not increase overall risk-taking. | | | | |  Antisense oligonucleotides (ASOs) have been proposed as a therapeutic approach to shut down the production of faulty proteins in a wide variety of diseases, including cancer. | |
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