Genetic variants may help explain who loses more weight and who gets side effects on GLP-1 drugs
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 Genetic variants may help explain who loses more weight and who gets side effects on GLP-1 drugsGenetic variants may help explain who loses more weight and who gets side effects on GLP-1 drugs
 
A large 23andMe-based GWAS found that common variants in GLP1R and GIPR help explain why some people lose more weight or experience more nausea and vomiting on GLP-1 drugs. The findings suggest genetics may eventually help predict who responds best to semaglutide or tirzepatide and who is more likely to develop side effects.
 
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More than a quarter of people with Type 2 diabetes take GLP-1 receptor agonists, but the popular diabetes drugs might not work as well for people who have certain genetic variants, according to a new study by Stanford Medicine scientists and their collaborators.
 
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 Insilico Medicine nominates AI-driven drug candidate for cancer, Cushing's syndrome and obesity
 
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 Study identifies new genes linked to severe pregnancy sickness
 
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 Extended work shifts disrupt normal cortisol patterns in female nurses
 
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 Long-term excess weight is a stronger predictor of cardiovascular risk
 
Long-term excess weight is a stronger predictor of cardiovascular riskObesity is a known risk factor for cardiovascular disease, but people's weights can shift over time, and little is known about the cumulative impact of excess weight.
 
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