A childhood shaped by sugar rationing was linked to mental health more than 50 years later
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 Only three of 1,357 FDA-cleared AI devices tested patient outcomesOnly three of 1,357 FDA-cleared AI devices tested patient outcomes
 
Researchers found that among 1,357 FDA-cleared or approved AI/ML-enabled medical devices, only 34 were linked to registered clinical trials and just three had been evaluated for patient-centered outcomes. The study highlights major gaps in prospective testing, demographic representation, transparency, and evidence showing whether medical AI meaningfully improves patients’ health.
 
 
 A childhood shaped by sugar rationing was linked to mental health more than 50 years laterA childhood shaped by sugar rationing was linked to mental health more than 50 years later
 
UK Biobank researchers examined whether sugar rationing during pregnancy and the first two years of life was associated with adult sweet-food preferences, sugar intake, brain structure, anxiety, and depression.
 
   Novel blood-based method diagnoses Alzheimer’s disease with high accuracyNovel blood-based method diagnoses Alzheimer’s disease with high accuracy
 
Alzheimer's disease (AD) accounts for 60–80% of global dementia cases, with its core pathological feature being the misfolding and aggregation of β-amyloid (Aβ) proteins in the brain.
 
   Psilocybin may make the brain more organized than scientists expectedPsilocybin may make the brain more organized than scientists expected
 
In 62 adults, researchers combined fMRI, EEG and machine learning to examine how psilocybin reshapes brain activity during rest, meditation, music and movie viewing. They found that context-sensitive neural organization tracked the intensity and quality of psychedelic experiences and was associated with next-day mindset change.
 
 SBRT improves bowel health related quality-of-life in patients with localized intermediate-risk prostate cancer
 
SBRT improves bowel health related quality-of-life in patients with localized intermediate-risk prostate cancerResults of the NRG Oncology NRG-GU005 clinical study comparing stereotactic body radiation therapy (SBRT) to moderately hypofractionated intensity-modulated radiation therapy (MH-IMRT) for patients with localized intermediate risk prostate cancer indicate that the use of SBRT improved bowel health related quality of life (HRQOL) in this patient population.
 
 
 Only 15% of eligible American adults discuss lung cancer screening with their doctors
 
Only 15% of eligible American adults discuss lung cancer screening with their doctorsLung cancer screenings can save lives by detecting cancer in its early stages, but only 15% of eligible American adults have discussed the screening with their doctors, according to data analysis performed by University of Cincinnati Cancer Center researchers.
 
 
 Glioma microenvironment emerges as key target for future therapies
 
Glioma microenvironment emerges as key target for future therapiesThe prognosis for glioma patients remains extremely poor despite aggressive multimodal standard therapy: maximal safe resection, radiotherapy, and temozolomide chemotherapy, with median survival rarely exceeding 15 to 18 months.
 
 
 Study: Nearly 8 out of 10 young adults have cardiovascular-kidney-metabolic syndrome
 
Study: Nearly 8 out of 10 young adults have cardiovascular-kidney-metabolic syndromeA new scientific study found that nearly 8 out of 10 young adult participants, average age 23 years, had cardiovascular-kidney-metabolic syndrome (CKM syndrome), according to new independent research published today in Circulation: Population Health and Outcomes, a peer-reviewed scientific journal of the American Heart Association.
 
 
 Protecting the thymus may improve lung cancer treatment outcomes
 
Protecting the thymus may improve lung cancer treatment outcomesBuilding on recent discoveries about the adult thymus, Mass General Brigham investigators used artificial intelligence to show that incidental radiation exposure to the thymus may influence outcomes in patients with lung cancer.
 
 
 Review outlines key strategies to reduce gynecologic cancer-related mortality
 
Review outlines key strategies to reduce gynecologic cancer-related mortalityLow- and middle-income countries (LMICs) bear a disproportionate burden of gynecologic malignancies-cancers of the cervix, endometrium, ovary, vagina, and vulva.
 
 
 Faulty myelin-making brain cells may help drive cognitive decline with age
 
Faulty myelin-making brain cells may help drive cognitive decline with ageResearchers found that greater age-related cognitive decline was associated with more dysfunctional oligodendrocytes, reduced NRF2 expression, smaller myelinated axons, and abnormally thicker myelin in human white matter. Experiments in mice showed that deleting NRF2 specifically from oligodendrocytes reproduced key white matter abnormalities and reduced cognitive improvement over time, implicating this pathway in cognitive aging.
 
 
 Review examines how medical imaging foundation models are moved toward clinical use
 
Review examines how medical imaging foundation models are moved toward clinical useAI is already widely used for lesion detection, disease classification, and outcome prediction in medical imaging, but most systems remain narrowly designed for one task and depend heavily on expert-labelled data.
 
 
 New NATO guidelines aim to protect soldiers' brains from blast exposures
 
New NATO guidelines aim to protect soldiers' brains from blast exposuresTwo University of Virginia researchers helped develop new NATO guidelines for protecting soldiers' brains from blast exposures common in military combat and training.
 
 
 New funding backs pioneering research to make brain cancer treatment more effective
 
New funding backs pioneering research to make brain cancer treatment more effectiveAdelaide researchers are challenging decades-old assumptions about brain cancer treatment in a bid to make radiation therapy more effective against tumors, while reducing damage to healthy tissue.
 
 
 Study links thymus radiation to worse lung cancer outcomes
 
Study links thymus radiation to worse lung cancer outcomesUntil recently, the thymus was thought to be of little use beyond puberty, but new research has shown that radiation to the organ is associated with worse outcomes in patients being treated for non-small cell lung cancer (NSCLC).
 
 
 Multi-target interventions may yield superior outcomes for chronic ankle instability
 
Multi-target interventions may yield superior outcomes for chronic ankle instabilityAnkle sprain is the most prevalent sports-related injury affecting the lower limbs, and up to 70% of individuals with ankle sprain experience persistent symptoms, such as sensorimotor impairment and balance deficits, which may ultimately progress to chronic ankle instability (CAI).
 
 
 Brain atrophy on MRI could help predict Alzheimer’s progression
 
Brain atrophy on MRI could help predict Alzheimer’s progressionMass General Brigham Neuroscience Institute researchers have found that a pattern of brain atrophy visible on MRI could help predict how quickly people with early-onset Alzheimer's disease progress from mild cognitive impairment to dementia.
 
 
 New grants support biotechnology and cancer research projects at KIT
 
New grants support biotechnology and cancer research projects at KITIn its CZS Nexus program, the Carl Zeiss Foundation has awarded grants to two young scientists from the Karlsruhe Institute of Technology (KIT). The researchers will each receive EUR 1.5 million to establish their own interdisciplinary working groups at KIT.
 
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