Study links childhood passive smoking in fathers to higher COPD risk in offspring

	Pulmonology
	The latest pulmonology news from News Medical

	Study links childhood passive smoking in fathers to higher COPD risk in offspring A father's exposure to passive smoking as a child may impair the lifelong lung function of his children, putting them at risk of COPD-a risk that is heightened further if they are childhood passive smokers themselves-finds research published online in the respiratory journal Thorax.

	What is cancer cachexia? Causes, symptoms, diagnosis, and treatment Discover how cancer cachexia transforms weight loss into a complex metabolic challenge that nutrition alone cannot fix, and why integrated therapies are reshaping patient outcomes.

			Tarlatamab and anti-PD-L1 therapy combination demonstrates manageable safety profile in first-line ES-SCLC Clinical data presented today demonstrates the combination of tarlatamab with anti-PD-L1 therapy as first-line maintenance has an acceptable safety profile and resulted in unprecedented overall survival in patients with extensive-stage small cell lung cancer (ES-SCLC).

			New guidelines for managing interstitial lung disease associated with connective tissue diseases EULAR - The European Alliance of Associations for Rheumatology - has worked with the European Respiratory Society (ERS) to develop new clinical practice guidelines for interstitial lung disease (ILD) associated with connective tissue diseases (CTD).

			Ivonescimab plus chemotherapy provides survival benefit for difficult-to-treat NSCLC patients Adding ivonescimab, a first-in-class bispecific antibody targeting both PD-1 and VEGF, to chemotherapy significantly prolonged progression-free survival (PFS) compared to chemotherapy alone in patients with advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations whose disease progressed on third-generation EGFR tyrosine kinase inhibitors (TKIs).

	Advances in ultrasound improve prenatal detection of congenital heart disease A new study published in The Annals of Thoracic Surgery, the journal from The Society of Thoracic Surgeons, suggests that prenatal detection of congenital heart disease (CHD) has improved in recent years largely due to advances in ultrasound screening practices.

	Osimertinib plus chemotherapy offers overall survival advantage for patients with EGFR-mutated advanced NSCLC Final overall survival (OS) results from the Phase III FLAURA2 trial demonstrate that first-line osimertinib plus chemotherapy significantly improves OS compared to osimertinib monotherapy in patients with EGFR-mutated (EGFRm) advanced non-small cell lung cancer (NSCLC).

	New antibody-drug conjugate iza-bren may offer promising treatment option for EGFR-mutated NSCLC patients A novel antibody-drug conjugate (ADC), iza-bren (BL-B01D1), demonstrated encouraging safety and efficacy results in previously treated patients with EGFR-mutated non-small cell lung cancer (NSCLC), according to findings presented at the International Association for the Study of Lung Cancer (IASLC) 2025 World Conference on Lung Cancer (WCLC).

	Study validates deep learning model for predicting future lung cancer risk in Black population A new study presented at the International Association for the Study of Lung Cancer 2025 World Conference on Lung Cancer (WCLC) validates the use of Sybil, a deep learning artificial intelligence model, for predicting future lung cancer risk in a predominantly Black population.

	Ifinatamab deruxtecan may benefit patients with recurrent or progressive ES-SCLC Patients diagnosed with recurrent or progressive extensive-stage small cell lung cancer (ES-SCLC) may benefit from treatment with ifinatamab deruxtecan (I-DXd), a B7-H3–directed antibody–drug conjugate, according to data presented today at the International Association for the Study of Lung Cancer (IASLC) 2025 World Conference on Lung Cancer (WCLC) in Barcelona, Spain.

	Older patients eligible for surgery can benefit from lung cancer screening programs Older individuals between the ages of 75 and 80 who are eligible for lung surgery may achieve survival outcomes comparable to younger patients following lung cancer screening, according to research presented today at the International Association for the Study of Lung Cancer (IASLC) 2025 World Conference on Lung Cancer (WCLC).

	Video-assisted thoracoscopic surgery provides improved overall survival compared to open lobectomy Patients who underwent video-assisted thoracoscopic surgery (VATS) compared to open lobectomy had a significantly improved overall survival rate, according to a meta-analysis presented at the International Association for the Study of Lung Cancer (IASLC) 2025 World Conference on Lung Cancer (WCLC).

	In vitro strategies for developing anti-TSLP biotherapeutics Explore in vitro strategies for developing anti-TSLP biotherapeutics, supporting early-stage screening and accelerated preclinical evaluation.

	Bedfont® to showcase the innovative Smokerlyzer® and NObreath® respiratory devices at ERS 2025 Bedfont® Scientific Limited, an innovative med-tech company with over 48 years of knowledge and expertise in the manufacture of medical breath analysis devices, are seeking new strategic distribution partners at this year's European Respiratory Society (ERS) Congress.

	HypoRT with concurrent chemotherapy reduces treatment time and toxicity for patients with LS-SCLC A multi-center, randomized phase III trial has found that a three-week hypofractionated radiotherapy (HypoRT) schedule with concurrent chemotherapy provides similar survival outcomes and reduced toxicity compared to the standard six-week conventional fractionated radiotherapy (ConvRT) schedule for patients with limited-stage small cell lung cancer (LS-SCLC).

	Adjuvant chemo-immunotherapy may benefit patients with resected stage IB–IIIA NSCLC, trial suggests Interim results from the NADIM ADJUVANT Phase III trial, led by the Spanish Lung Cancer Group (GECP), suggest that adjuvant chemo-immunotherapy may reduce the risk of recurrence in patients with completely resected stage IB–IIIA non-small cell lung cancer (NSCLC) while maintaining an acceptable safety profile.

	Aspirin therapy does not help people suffering from chronic rhinosinusitis with nasal polyps A randomized placebo-controlled Finnish study showed that aspirin therapy does not provide significant relief for people suffering from chronic rhinosinusitis with nasal polyps who are hypersensitive to non-steroidal anti-inflammatory drugs (NSAIDs).

	CPAP treatment may reduce death risk in people with both type 2 diabetes and sleep apnea People with both type 2 diabetes (T2D) and obstructive sleep apnea have a higher risk of death, but treatment with continuous positive airway pressure (CPAP) may reduce that risk by around 26%, according to new research being presented at this year's Annual Meeting of The European Association for the Study of Diabetes (EASD), Vienna (15-19 Sept).

	Study highlights potential value of low-dose CT screening for lung cancer among Asian women Results from the Female Asian Nonsmoker Screening Study (FANSS) highlight the potential value of low-dose CT (LDCT) screening for lung cancer among a growing but underserved population: Asian women with no history of smoking.

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