Genetic variants may help explain who loses more weight and who gets side effects on GLP-1 drugs
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 Want muscle from creatine? Resistance training is the missing linkWant muscle from creatine? Resistance training is the missing link
 
A meta-analysis reveals creatine enhances high-intensity performance, with muscle gains linked to resistance training context and supplementation.
 
 
 Genetic variants may help explain who loses more weight and who gets side effects on GLP-1 drugsGenetic variants may help explain who loses more weight and who gets side effects on GLP-1 drugs
 
A large 23andMe-based GWAS found that common variants in GLP1R and GIPR help explain why some people lose more weight or experience more nausea and vomiting on GLP-1 drugs. The findings suggest genetics may eventually help predict who responds best to semaglutide or tirzepatide and who is more likely to develop side effects.
 
 
 Vaping may raise cognitive impairment risk in young adults, study findsVaping may raise cognitive impairment risk in young adults, study finds
 
A cross-sectional study of 232 young adults in Bangkok found that e-cigarette users were more likely than non-smokers to screen as at risk for cognitive impairment on the MoCA, while no significant differences were seen for ADHD symptom tendency or emotional intelligence.
 
 
 Lab study shows cigarette smoke damaged lung cells more than e-cigarette vaporLab study shows cigarette smoke damaged lung cells more than e-cigarette vapor
 
Researchers found that cigarette smoke extract disrupted the lung cell barrier, increased IL-6 inflammation, and caused DNA damage in Calu-3 cells, while e-cigarette vapor extract showed no significant adverse effects on these measures under the study conditions. The authors caution that these were in vitro findings using liquid extracts and unflavored e-liquid, so they do not directly predict long-term human health outcomes.
 
   Gaining weight before age 30 tied to higher mortalityGaining weight before age 30 tied to higher mortality
 
The study reveals that weight gain before 30 years is associated with increased mortality risk, underscoring the need for early obesity intervention strategies.
 
   Large US study finds never-married adults face higher risk for most major cancersLarge US study finds never-married adults face higher risk for most major cancers
 
A large US population-based study found that never-married adults had higher cancer incidence than ever-married adults across most cancer types, with the largest disparities seen in older adults and in Black men. The pattern was especially strong for HPV-related, tobacco-related, and several reproductive cancers, suggesting marital status may act as an important social marker of cancer risk.
 
   Higher optimism may lower dementia risk in older adultsHigher optimism may lower dementia risk in older adults
 
Higher optimism in adults aged 70 and older was associated with a lower risk of developing dementia over up to 14 years of follow-up in the Health and Retirement Study. The association remained after adjustment for demographic factors, depression, health conditions, smoking, and physical activity, although the study was observational and cannot prove causation.
 
   Beetroot supplement raises nitric oxide markers in triathletes after one weekBeetroot supplement raises nitric oxide markers in triathletes after one week
 
A randomized cross-over pilot study in 10 amateur male triathletes found that a beetroot-based multi-ingredient nitrate supplement increased nitric oxide-related and redox biomarkers over 7 days without evidence of lipid oxidative damage. The supplement was generally well tolerated, but the study did not measure whether these biochemical changes improved performance or recovery.
 
 Prostate cancer patients recover faster with TULSA than robotic surgery
 
A new randomized clinical trial found that men with localized, intermediate‑risk prostate cancer recovered faster and experienced less short‑term impact on their daily lives when treated with MRI‑guided, transurethral ultrasound ablation (TULSA) compared with robotic prostate surgery.
 
 
 Why early-onset cancers are rising and how researchers plan to stop them
 
Why early-onset cancers are rising and how researchers plan to stop themEarly-onset cancers are rising worldwide, and this Cell Perspective argues that cancer prevention must move beyond static risk-factor snapshots toward life-course exposure mapping, tissue-level biology, and dynamic estimates of preventability. The authors propose three linked frameworks to speed discovery of cancer causes and translate those findings into more precise prevention and interception strategies.
 
 
 Study shows why an apple a day may work differently for different people
 
Study shows why an apple a day may work differently for different peopleA 12-week single-blind trial in 38 Japanese adults found that daily Fuji apple intake did not significantly change overall host metabolic markers, but responses differed by baseline gut enterotype. Participants in the Bacteroidaceae-dominant enterotype showed significant increases in fecal short-chain fatty acids after apple consumption, suggesting that gut microbiota structure may shape functional dietary responses.
 
 
 Parents’ intake of sugar substitutes may influence offspring gut biology, study finds
 
Parents’ intake of sugar substitutes may influence offspring gut biology, study findsA mouse study in Frontiers in Nutrition found that parental sucralose and stevia intake altered gut microbiota, short-chain fatty acids, and gene expression across generations, with sucralose showing the stronger and more persistent effects. The changes were transmitted to offspring not directly exposed to the sweeteners, although several effects were attenuated by the F2 generation.
 
 
 Study finds when parents are depressed may shape children’s mental health for decades
 
Study finds when parents are depressed may shape children’s mental health for decadesA long-running UK cohort study found that exposure to parental depression from pregnancy through young adulthood was linked to higher odds of depression and anxiety in adult offspring. Maternal depression in late pregnancy was uniquely associated with later psychotic symptoms, while paternal associations emerged more clearly from mid-childhood onward.
 
 
 Cola may quickly lower pH inside orthodontic clear aligners and shift oral bacteria within hours
 
Cola may quickly lower pH inside orthodontic clear aligners and shift oral bacteria within hoursResearchers found that cola exposure quickly lowered pH and altered the microbiome on the inner surface of clear aligners, with the greatest disruption observed when aligners were removed before drinking and then reinserted. In this small 24-hour study, wearing aligners during exposure appeared less disruptive than removing them, though the authors said the mechanism still needs further study.
 
 
 Talc not contaminated with asbestos shows no link to cancer
 
Talc not contaminated with asbestos shows no link to cancerIn a systematic review and meta-analysis, researchers found that occupational exposure to talc that is not contaminated with asbestos is not associated with an increase in the risk of lung cancer, mesothelioma, or laryngeal cancer.
 
 
 Targeting super-enhancer mechanisms offers new strategies for cancer therapy
 
Targeting super-enhancer mechanisms offers new strategies for cancer therapySuper-enhancers (SEs) are large clusters of transcriptional regulatory elements that drive oncogene expression, maintain malignancy, and create "transcriptional addiction" in cancer.
 
 
 Metabolic syndrome doubles worldwide over two decades
 
Metabolic syndrome doubles worldwide over two decadesA global study reveals a sharp rise in metabolic syndrome prevalence from 2000 to 2023, highlighting urgent public health challenges and regional disparities.
 
 
 Pseudogene lncRNAs regulate cancer stem cell behavior and signaling
 
Pseudogene lncRNAs regulate cancer stem cell behavior and signalingCancer stem cells (CSCs), a critical subpopulation within tumors, drive cancer initiation, progression, metastasis, relapse, and resistance to therapy due to their innate capacity for self-renewal and differentiation.
 
 
 Threat-response in the brain's amygdala linked to sex-specific patterns of alcohol use
 
Threat-response in the brain's amygdala linked to sex-specific patterns of alcohol useNew research shows that the threat-response in the brain's amygdala (which processes emotions) is linked to different patterns of drinking by sex.
 
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