Antibodies - One-Step ADC Manufacturing: Higher Yields, Less Complexity
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Accelerating Antibody Discovery From Concept to INDAccelerating Antibody Discovery From Concept to IND

This eBook from Pharmaron explores integrated antibody discovery and development, covering monoclonal, bispecific, and multispecific programs. Learn how phage display, humanization, Fc engineering, high-throughput expression, advanced biophysical characterization, and robust PK/PD bioanalysis combine with GMP manufacturing, GLP toxicology, and regulatory support to accelerate confident IND submission for modern antibody pipelines.

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    One-Step ADC Manufacturing: Higher Yields, Less ComplexityOne-Step ADC Manufacturing: Higher Yields, Less Complexity
 
ADC developers face mounting pressure as pipelines grow and manufacturing bottlenecks intensify. A new one-step, site-specific glycoengineering strategy delivers >95% conjugation yields in under an hour, producing homogeneous ADCs with defined DAR. This streamlined approach reduces risk, cost, and regulatory burden, reshaping CDMO-led ADC manufacturing.
 
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   Trojan horse immunotherapy opens tumors to immune system attackTrojan horse immunotherapy opens tumors to immune system attack
 
Scientists at the Icahn School of Medicine at Mount Sinai have developed an experimental immunotherapy that takes an unconventional approach to metastatic cancer: instead of going after cancer cells directly, it targets the cells that protect them.
 
 Lower IgG Hinge Controls Antibody Assembly and Immune Function
 
Lower IgG Hinge Controls Antibody Assembly and Immune FunctionThe lower hinge of immunoglobulin G (IgG), an overlooked part of the antibody, acts as a structural and functional control hub, according to a study by researchers at Science Tokyo.
 
 
 Single-dose HIV vaccine candidate induces neutralizing antibodies
 
Single-dose HIV vaccine candidate induces neutralizing antibodiesScientists at The Wistar Institute have developed an HIV vaccine candidate that achieves something never before observed in the field: inducing neutralizing antibodies against HIV after a single immunization in nonhuman primates.
 
 
 Targeted Fab fragments dismantle the allergy trigger
 
Targeted Fab fragments dismantle the allergy triggerAllergic diseases represent a major global health burden, placing significant strain on healthcare systems worldwide. Severe conditions such as anaphylaxis, asthma, food allergy, and allergic rhinitis are driven by immunoglobulin E (IgE), an antibody that binds to immune cells, including mast cells and basophils.
 
 
 New platform improves prediction of human antibody drug responses
 
New platform improves prediction of human antibody drug responsesAn international research consortium, led by scientists at VIB and UGent, has developed a new platform that could change how antibody medicines are tested and brought to patients. The
 
 
 Lower hinge of immunoglobulin G acts as a critical immune control hub
 
Lower hinge of immunoglobulin G acts as a critical immune control hubThe lower hinge of immunoglobulin G (IgG), an overlooked part of the antibody, acts as a structural and functional control hub, according to a study by researchers at Science Tokyo.
 
 

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