Inflammation and immune dysregulation drive breast cancer in aging women

	Breast Cancer
	The latest breast cancer news from News Medical

	Inflammation and immune dysregulation drive breast cancer in aging women Age-related and postmenopausal breast cancer progression remains a significant challenge, with growing evidence pointing to the role of pro-inflammatory cytokines and CXC chemokines in tumor development and immune system modulation.

	How do genetics and diet shape the human microbiome? Discover how genetics and diet shape the human gut microbiome, influencing health, metabolism, and disease risk. Explore implications for precision nutrition.

			New DNA test predicts chemotherapy resistance in cancer patients Cancer Research UK-funded scientists at the University of Cambridge, in collaboration with the Spanish National Cancer Research Centre (CNIO) and Cambridge-based startup Tailor Bio, have created a test which can successfully predict whether cancer will resist common forms of chemotherapy treatment.

			Healthy gut microbiome before chemo could help protect breast cancer patients against cardiotoxicity New research suggests that a healthy microbiome before chemotherapy could help protect breast cancer patients against heart damage, or cardiotoxicity, as a result of cancer therapy.

			Transfer RNA-derived small RNAs transform the landscape of liquid biopsy A new review highlights the transformative potential of transfer RNA-derived small RNAs (tsRNAs) in the field of liquid biopsy, emphasizing their role as promising biomarkers for a wide range of diseases, particularly cancers.

	New switchable CAR-T therapy enters phase 1 trial for advanced breast cancer The Calibr-Skaggs Institute for Innovative Medicines, the drug development division of Scripps Research, today announced a milestone in cancer treatment with the dosing of the first patient in a phase 1 trial (NCT06878248) evaluating CLBR001 + ABBV-461, a modular, switchable chimeric antigen receptor T cell (sCAR-T) therapy in patients with advanced or metastatic breast cancer who have no suitable treatment options.

	New clinical trial tests non-invasive method to protect hearts during chemotherapy A simple intervention, similar to the tension applied to the arm during a blood pressure reading, is being tested in a Phase II clinical trial to see if it can help cancer patients treated with common chemotherapy drugs, called anthracyclines, avoid heart failure.

	New technology tracks solid tumor treatment response through blood samples Altum Sequencing, a start-up supported by the C3N-IA Science Park at Universidad Carlos III de Madrid (UC3M) and specialized in oncology, has developed a tool to monitor treatment response in patients with solid tumors from a simple blood sample.

	Scientists find hundreds of genes that behave like light switches Gene expression, where cells use the genetic information encoded in DNA to produce proteins, has been thought of as a dimmer light.

	New AI tool characterizes the diversity of individual cells within tumors A multinational team of researchers, co-led by the Garvan Institute of Medical Research, has developed and tested a new AI tool to better characterize the diversity of individual cells within tumors, opening doors for more targeted therapies for patients.

	Quantifying breast cancer heterogeneity through single-cell transcriptomics Tumors are complex systems characterized by variations across genetic, transcriptomic, phenotypic, and microenvironmental levels.

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