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The latest breast cancer news from News Medical |
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 | | |  Higher BMI raises risk for 19 cancers as global review expands the obesity-cancer link A major systematic review and meta-analysis links higher BMI to increased risk of 19 cancer types, including leukemia, non-Hodgkin lymphoma, bladder cancer, and glioma, which were not previously recognized in major consensus reports. The study also reveals regional and sex-based variation in cancer risk, with genetic evidence generally supporting many observational links while highlighting the need for more diverse global cohorts. | | | | |  New human protein atlas maps how cancer rewires the body’s tissues Researchers created a DIA-MS atlas of 13,609 proteins across 2,856 samples from fetal, healthy adult, paired non-tumor, and tumor tissues. The resource maps tissue-specific protein patterns, cancer-associated changes, organ-specific drug-toxicity signals, and candidate therapeutic targets. | |
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|  | | | | |  Eating 90 g of wholegrains daily linked to lower breast cancer risk Research indicates that long-term wholegrain intake per Nordic guidelines is associated with reduced breast cancer risk, emphasizing food type differences. | |  | | | | |  Gut microbes emerge as potential players in estrogen-driven cancers A new review maps how the endocrine-microbiome axis expands the estrobolome concept, showing that gut microbes may alter estrogen recycling, produce hormone-like metabolites, and shape inflammation and tissue environments in hormone-driven cancers. | | | | | | |  Semaglutide, omega-3s and diet shift epigenetic aging clocks in human studies A systematic review identified 41 human studies evaluating interventions targeting next-generation DNA methylation-based aging clocks. Pharmaceutical, lifestyle, supplement, clinical, and psychosocial interventions shifted some clock outputs, but these biomarkers remain investigational rather than proven clinical surrogates. | |
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| | | |  Researchers are calling for the application of locally driven strategies, supported by stronger regional evidence, to improve early cancer detection and precise care. | | | | |  A new study from the Icahn School of Medicine at Mount Sinai shows that social determinants of health-including environmental conditions, health behaviors, access to resources, and social well-being-can play an equally important or even greater role than genetics in predicting a person's risk of developing common diseases. | | | | |  Using artificial intelligence (AI), researchers found that image-based risk scores for breast cancer derived from screening mammograms evolve over time and differ between women who develop cancer and those who do not, opening the door to a new era of dynamic breast cancer risk assessment. | | | | |  As people continue to live longer and the survival rate of cancer diagnoses increases, researchers from VCU Massey Comprehensive Cancer Center led a multi-decade analysis studying the rates of subsequent primary cancers (SPCs), which are new cancers unrelated to the original diagnosis. | | | | |  After nearly four decades of research, Mayo Clinic scientists have revealed the molecular structures of protein kinase C beta (PKCβ), a key protein linked to cancer and neurological diseases. | | | | |  Universities and hospitals are repurposing existing drugs through late-stage trials with funded costs up to 90% lower than those taking place in the pharmaceutical industry. | | | | |  Today, Alliance Foundation Trials, LLC (AFT) was informed that the U.S. Food and Drug Administration has approved palbociclib in combination with trastuzumab, with or without pertuzumab, and endocrine therapy for adult patients with hormone receptor–positive (HR+), human epidermal growth factor receptor 2–positive (HER2+) locally advanced or metastatic breast cancer following induction treatment. | | | | | Traditional cancer treatments like chemotherapy and radiotherapy can induce immunogenic cell death (ICD), but their efficacy is often limited by drug resistance, severe off-target toxicity, and immune-related adverse events. | | | | | Triple-negative breast cancer (TNBC) is aggressive and hard to treat. But the role of fat tissue in how the cancer spreads may help point toward new understanding and treatments, according to a new paper from scientists at the Hackensack Meridian Center for Discovery and Innovation (CDI) and colleagues at Georgetown University's Lombardi Comprehensive Cancer Center. | | | | | Research led by RCSI University of Medicine and Health Sciences and University College Dublin (UCD) has identified immune markers that could help doctors more accurately determine which breast cancer patients are unlikely to benefit from chemotherapy, potentially sparing some patients from unnecessary treatment. | |
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