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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Antibiotic minocycline might help alleviate HIV's negative effects on the brain and central nervous system

By studying animals, Johns Hopkins researchers have discovered that the antibiotic minocycline might help alleviate HIV's negative effects on the brain and central nervous system, problems that can develop even though antiretroviral therapy controls the virus elsewhere in the body.

1 May 2005

Researchers show protein's role in stopping bacterial-induced inflammation

In findings that could have implications for autoimmune disorders and drug-resistant bacterial infections, researchers at the University of California, San Diego (UCSD) School of Medicine have identified a key protein involved in the appropriate shut-down of inflammation following an immune response to invading pathogens.

28 Apr 2005

Mutations in the HFE gene directly associated with chronic joint disease

Mutations in the HFE gene, which is involved in iron regulation, seem to be directly associated with chronic joint disease (or haemophilic arthropathy) among haemophilic patients, claim a team of Portuguese scientists in the April issue of the journal Blood.

4 Apr 2005

Airway inflammation boosts infarction damage

Epidemiological studies show that the incidence of cardiovascular disease (CVD) complications are increased in long standing cases of asthma. Historically, the complications are often attributed to the chronic drug therapy used to treat asthma.

3 Apr 2005

Discovery of missing enzyme for tuberculosis iron scavenging pathway

Scientists have discovered that a protein that was originally believed to be involved in tuberculosis antibiotic resistance is actually a "missing enzyme" from the biosynthetic pathway for an agent used by the bacteria to scavenge iron.

30 Mar 2005

Optical coherence tomography (OCT) can successfully identify the characteristics of coronary plaques

A catheter-based imaging technology called optical coherence tomography (OCT) can successfully identify the characteristics of coronary plaques in patients with various cardiac symptoms. The report from researchers at Massachusetts General Hospital (MGH) will appear in the journal Circulation.

29 Mar 2005

Hope of new treatments for liver damage

There is currently no cure for liver cirrhosis and a patient's only hope of survival is to receive a liver transplant.

28 Mar 2005

How does the body keep the number of neutrophils produced constant in the blood?

Every day, the human body manufactures and destroys about 100 billion neutrophils- the most common type of white blood cell and one of the most highly-produced cells. Neutrophils live about eight hours, are bacteria-eaters and are a key component of the immune system. Without them, the body can be subject to life-threatening infection.

23 Mar 2005

Structure of key protein in innate immune response

In a report published in the Journal of Biological Chemistry, scientists in Korea announced their elucidation of three-dimensional structure of CD14 and showed how it is perfectly suited to bind to certain bacterial products.

21 Mar 2005

Chemists say they have identified a gene that appears to play a key role in the development of type 1 diabetes

In the current study, the researchers focused on the formation of the MIF protein (macrophage migration inhibitory factor), a proinflammatory protein that they showed in previous studies is elevated in diabetic animals and may be involved in the cascade of immunological events that leads to the destruction of the pancreas and the subsequent onset of type 1 diabetes.

21 Mar 2005

Link between C-reactive protein, heart disease and stroke

The cells that line the arteries are able to produce C-reactive protein, according to a study funded by the National Institutes of Health and published in the April issue of American Journal of Pathology.

16 Mar 2005

New immunotherapeutic approach against anthrax

The anthrax attacks in the aftermath of September 11, 2001 in the USA have illustrated the high potential of anthrax for misuse in bio-terrorism. Dissemination of anthrax by letters led to the death of 5 people and chemotherapeutic treatment of 30,000 individuals.

15 Mar 2005

Process behind cellular export of iron may help to explain human hemochromatosis

The first direct evidence that a single protein is critical in the cellular export of iron may help to explain human hemochromatosis, researchers report in the March issue of Cell Metabolism.

15 Mar 2005

Discovery may provide a new target to treat sepsis

Part of the immune system's pro-inflammatory response to bacterial invasion is to increase nitric oxide levels with an enzyme called inducible nitric oxide synthase.

14 Mar 2005

Air pollution thickens the blood and boosts inflammation

Air pollution, and especially particulate matter, thickens the blood and boosts inflammation, finds experimental research in Occupational and Environmental Medicine.

20 Feb 2005

Further evidence for the role of cyclooxygenases (COX) in heart-disease risk

In two articles, published in Circulation, researchers from the University of Pennsylvania School of Medicine provide further evidence for the role of cyclooxygenases (COX) in heart-disease risk.

17 Jan 2005

Scientists examine the role of small sputum macrophages in the widespread disease chronic obstructive bronchitis

COPD (chronic obstructive pulmonary disease) is one of the most common fatal diseases worldwide. In Germany alone, there are about 3-5 million patients affected. COPD includes both chronic obstructive bronchitis and emphysema. Both represent irreversible changes of the central and lower respiratory tract which are accompanied by coughing, mucus production and difficulty in breathing.

10 Jan 2005

Mutated gene may provide better idea of how cancer develops and progresses

Scientists are taking the first steps to find out how a gene that is mutated in many cancer cells functions in healthy cells.

6 Jan 2005

New hope for millions of patients suffering from liver damage (cirrhosis)

Millions of patients suffering from liver damage (cirrhosis) and failure may benefit from research by the Universities of Edinburgh and Southampton which may lead to new life-saving treatments. There is currently no cure for liver cirrhosis and a patient's only hope of survival is to receive a liver transplant.

5 Jan 2005

Compounds in Christmas trees could help treat arthritis and pain

Researchers have identified a group of anti-inflammatory compounds in the bark of the Scotch pine - widely used for Christmas trees - that they say could be developed into food supplements or drugs for treating arthritis and pain.

13 Dec 2004