Induced Pluripotent Stem Cells News and Research

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Genetic mutation in OXR1 gene linked to brain development issues

Study investigates the effects of a loss-of-function mutation in the OXR1 gene on neurodevelopment and cellular functions in the human brain. The research shows that OXR1 deficiency impairs neural differentiation, increases sensitivity to oxidative stress, and alters histone methylation, impacting brain development and potentially contributing to neurological disorders.

27 Nov 2023

Rare APOE3-R136S mutation offers protection against Alzheimer's disease pathologies in new study

The R136S genetic mutation protected against apolipoprotein E4 (APOE4)-induced late-onset Alzheimer’s disease (LOAD).

16 Nov 2023

Bioengineered human heart muscle cells and micro-tissues take flight to space

Mount Sinai's Cardiovascular Research Institute is sending bioengineered human heart muscle cells and micro-tissues into space for the first time on NASA's 29th SpaceX commercial resupply services mission, which launched Thursday, November 9.

14 Nov 2023

"Christchurch mutation" can block detrimental effects of Alzheimer’s risk factor

Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the "Christchurch mutation" can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most common form of Alzheimer's disease.

13 Nov 2023

Researchers harness a combination of lab-grown cells to regenerate damaged heart muscle

Researchers at the University of Wisconsin–Madison and Academia Sinica of Taiwan have harnessed a combination of lab-grown cells to regenerate damaged heart muscle.

31 Oct 2023

New MECP2 gene variant identified and characterized in Rett syndrome

Rett syndrome is a rare devastating neurological disorder that primarily affects young girls and manifests as an impaired ability to walk and talk, along with characteristic 'hand-wringing' movements, seizures, and cognitive disability.

30 Oct 2023

New insights into the molecular basis of schizophrenia during early brain development

Schizophrenia is a severe neuropsychiatric disease that remains poorly understood and treated.

24 Oct 2023

New model helps to better understand how Alzheimer's disease progresses in the brain

A new model developed by Van Andel Institute, Lund University and University of Florence scientists will enable researchers to better understand how Alzheimer's disease progresses in the brain.

18 Oct 2023

Fragile X syndrome may be unfolding in brain cells even before birth

Fragile X syndrome, the most common form of inherited intellectual disability, may be unfolding in brain cells even before birth, despite typically going undiagnosed until age 3 or later.

10 Oct 2023

DNA aptamers: A versatile tool for regenerative medicine and beyond

Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine.

10 Oct 2023

3D printing crafts cerebral cortex tissues: A breakthrough for brain injury treatment

Researchers utilize 3D printing to craft cerebral cortex tissues with organized neurons, offering potential treatments for brain injuries. This novel technique prints neural progenitors in layer-by-layer sequences, aiming for accurate tissue restoration in damaged brains.

8 Oct 2023

Breakthrough technique could one day provide tailored repairs for people with brain injuries

A breakthrough technique developed by University of Oxford researchers could one day provide tailored repairs for those who suffer brain injuries.

4 Oct 2023

Trametinib: Potential therapeutic game-changer for Alzheimer's disease

Researchers developed the ATRIVIEW® platform to screen for molecules that promote differentiation neural stem cells (NSCs).

4 Oct 2023

Microglial states and their impact on Alzheimer's disease

Researchers examined 152,459 microglial transcriptomes from 443 individuals, identifying 12 transcriptional states and their relationship to Alzheimer's disease.

3 Oct 2023

Dual CRISPR-Cas3 is a promising tool to induce a gigantic genomic deletion and restore dystrophin protein

Researchers evaluated the use of a dual clustered regularly interspaced short palindromic repeats (CRISPR)-Cas3 system.

29 Aug 2023

Texas Heart Institute receives $2 million NIH grant to develop transplantable bioartificial hearts

The Texas Heart Institute recently received a five-year, $2 million grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to advance the technology supporting development of transplantable bioartificial hearts.

25 Aug 2023

Stem cells used to create organoids that secrete dental enamel proteins

Organoids have now been created from stem cells to secrete the proteins that form dental enamel, the substance that protects teeth from damage and decay.

14 Aug 2023

Autism spectrum disorder may be linked to imbalance of neurons in the brain

Using human "mini-brain" models known as organoids, Mayo Clinic and Yale University scientists have discovered that the roots of autism spectrum disorder may be associated with an imbalance of specific neurons that play a critical role in how the brain communicates and functions.

10 Aug 2023

Miniature heart model holds the key to saving lives and enhancing patient outcomes

Discovery led by Prof. Yaakov Nahmias from the Hebrew University marks a new era in cardiovascular research, multi-chambered, self-paced miniature heart model, holding the key to saving lives and enhancing patient outcomes.

7 Aug 2023

Childhood abuse can induce stress that changes neural networks and functions during growth

Childhood neglect and/or abuse can induce extreme stress that significantly changes neural networks and functions during growth. This can lead to mental illnesses, including depression and schizophrenia, but the exact mechanism and means to control it were yet to be discovered.

4 Aug 2023