Lymph Node News and Research

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Lymph is clear or white fluid that travels through vessels, moves within tissues and work to keep all the parts of the body clean. After passing through the channels of the lymphatic system they drain into the lymph nodes. The lymph nodes act as filters along the lymphatic system. These nodes trap germs like bacteria, viruses, toxins as well as cancer cells and ensure that these are removed from the body.

Penn analysis shows low risk of secondary cancers following CAR T cell therapy

The development of any type of second cancer following CAR T cell therapy is a rare occurrence, as found in an analysis of more than 400 patients treated at Penn Medicine, researchers from the Perelman School of Medicine at the University of Pennsylvania reported today in Nature Medicine.

24 Jan 2024

New study reveals key tissues involved in HIV rebound after treatment

In findings that have implications for potential new HIV therapies, researchers from Texas Biomedical Research Institute (Texas Biomed) used genetic sequencing techniques on the nonhuman primate version of the virus to identify that lymph nodes in the abdomen are the leading source of rebound infection after the first week of stopping antiretroviral treatment.

24 Jan 2024

AI model accurately predicts lymph node metastasis in nonfunctional pancreatic neuroendocrine tumors

Nonfunctional pancreatic neuroendocrine tumors, while rare, are primarily treated through surgery. The presence or absence of lymph node metastasis considerably influences the selection of surgical and other treatment approaches.

23 Jan 2024

Evaluating the effectiveness and safety of single-port robot-assisted technique in nipple-sparing mastectomy procedures

Researchers evaluated the safety and feasibility of a single-port (SP) robotic-assisted approach for performing nipple-sparing mastectomies (NSM).

19 Jan 2024

New approach using ultrasound-guided drug delivery effectively targets lymph node metastasis

Researchers at Tohoku University have discovered a new approach for treating lymph node metastasis. Anticancer drugs are administered directly into the LNs under ultrasound guidance (Lymphatic Drug Delivery System or LDDS) to target sentinel lymph nodes (LNs) and generate antitumor effects locally, preventing distant metastasis.

12 Jan 2024

New combination treatment offers hope for older patients with mantle cell lymphoma

The phase 2 trial PrE0405 met its primary endpoint, achieving a complete response (CR) rate of 85% in 33 patients over the age of 60 with mantle cell lymphoma (MCL) who received bendamustine and rituximab, a standard chemo-immunotherapy treatment, along with venetoclax, which is investigational in this setting.

11 Dec 2023

Neoadjuvant chemotherapy can eliminate need for regional nodal irradiation in breast cancer

For patients whose breast cancer converted from lymph node-positive to lymph node-negative disease after neoadjuvant chemotherapy, skipping adjuvant regional nodal irradiation (RNI) did not increase the risk of disease recurrence or death five years after surgery, according to results from the NRG Oncology/NSABP B-51/RTOG 1304 clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

6 Dec 2023

Resident Tregs found to remain in certain lymph nodes for a long time

The immune system is fast when it comes to fighting viruses, bacteria and other pathogens. But it also has to know when not to attack - for example, harmless substances such as pollen or house dust, which otherwise trigger allergic reactions.

30 Oct 2023

Oxford Vaccine Group launches a pioneering study into human immunity

This study will test the responses of cells in lymph nodes before and after immunization with flu and COVID-19 vaccines and compare reactions in older and younger adults.

25 Oct 2023

Neoadjuvant pembrolizumab achieves major pathologic response in more than half of patients with resectable melanoma

In exploratory analyses of results from the SWOG S1801 trial in patients with stage III-IV resectable melanoma, researchers saw a major pathologic response in more than half of surgical specimens taken from patients who had been treated with neoadjuvant (pre-operative) pembrolizumab.

24 Oct 2023

Online educational materials about breast surgery often difficult to access and understand

Women with breast cancer must often make complex decisions about surgery and treatment options during an already stressful time in their lives, and many of these women may turn to the wide variety of materials available online.

20 Oct 2023

Researchers develop AI-based tool for estimating cancer patient's chances for survival

Researchers have developed an artificial intelligence (AI)–based tool for estimating a newly diagnosed cancer patient's chances for surviving long term, according to a study presented at the American College of Surgeons (ACS) Clinical Congress 2023.

20 Oct 2023

Cracking the code: recent discoveries transform our understanding of cancer-immunity cycle

In a recent review published in Immunity, researchers reviewed tumor-immunity cycle data.

13 Oct 2023

Larger lymph node threshold helps facilitate better risk stratification and treatment decisions in nasopharyngeal carcinoma

According to the American Journal of Roentgenology (AJR), using a 6-mm threshold, rather than a 5-mm threshold, helps facilitate better risk stratification and treatment decisions in patients with nasopharyngeal carcinoma (NPC).

29 Sep 2023

Study sheds light on immune cells' ability to collectively migrate through complex environments

When fighting disease, our immune cells need to reach their target quickly. Researchers at the Institute of Science and Technology Austria (ISTA) now discovered that immune cells actively generate their own guidance system to navigate through complex environments.

1 Sep 2023

Lymph Node News and Research

Further Reading

Penn analysis shows low risk of secondary cancers following CAR T cell therapy

New study reveals key tissues involved in HIV rebound after treatment

AI model accurately predicts lymph node metastasis in nonfunctional pancreatic neuroendocrine tumors

Evaluating the effectiveness and safety of single-port robot-assisted technique in nipple-sparing mastectomy procedures

New approach using ultrasound-guided drug delivery effectively targets lymph node metastasis

New combination treatment offers hope for older patients with mantle cell lymphoma

Neoadjuvant chemotherapy can eliminate need for regional nodal irradiation in breast cancer

Resident Tregs found to remain in certain lymph nodes for a long time

Oxford Vaccine Group launches a pioneering study into human immunity

Neoadjuvant pembrolizumab achieves major pathologic response in more than half of patients with resectable melanoma

Online educational materials about breast surgery often difficult to access and understand

Researchers develop AI-based tool for estimating cancer patient's chances for survival

Cracking the code: recent discoveries transform our understanding of cancer-immunity cycle

Larger lymph node threshold helps facilitate better risk stratification and treatment decisions in nasopharyngeal carcinoma

Study sheds light on immune cells' ability to collectively migrate through complex environments

Novel multi-epitope subunit vaccine induces robust immune response against Epstein-Barr virus

New trial to assess sentinel lymph node removal during surgery for early-stage endometrial cancer

Study sheds light on how breast cancer spreads to lymph nodes

Predicting bone metastases type in prostate cancer using MRI

Breast cancer and MEN1: exploring the connection

Immunology eBook

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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