Dyspnea News and Research

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Dyspnea or dyspnoea or shortness of breath is a debilitating symptom that is the experience of unpleasant or uncomfortable respiratory sensations.

Avastin (bevacizumab) shows promise in phase II study of glioblastoma multiforme

Genentech, Inc. has announced that both study arms of a randomized, multi-center Phase II clinical study of Avastin (bevacizumab) administered alone or in combination with irinotecan chemotherapy demonstrated encouraging six-month progression-free survival (PFS) and objective response rate in patients with relapsed glioblastoma multiforme (GBM), the most common and aggressive type of brain cancer.

19 Nov 2007

New method for early diagnosis of pulmonary hypertension

Researchers at the University of Granada ( UGR ) from the Systemic Autoimmune Diseases Unit and the Cardiology Service of the Hospital Clínico San Cecilio in Granada have developed an innovative system which will help doctors make the earliest diagnosis of pulmonary hypertension possible, which is the main cause of death for patients suffering from scleroderma, a rare disease which affects approximately 1,200 out of every million people.

14 Nov 2007

Tezosentan does not appear to improve symptoms for patients with acute heart failure

The medication tezosentan, which was thought could be beneficial for the treatment of acute heart failure, did not improve breathlessness or reduce the risk of fatal or nonfatal cardiovascular events, according to a study in the November 7 issue of JAMA.

6 Nov 2007

Broncus Technologies reports positive results for airway bypass procedure for the treatment of emphysema

Broncus Technologies, Inc., a medical device company investigating the airway bypass procedure for the treatment of emphysema, has announced that the results of its open-label Exhale Drug-Eluting Stent feasibility study have been published in the October issue of the Journal of Thoracic and Cardiovascular Surgery.

10 Oct 2007

Most comprehensive recommendations related to lung cancer

New evidenced-based guidelines from the American College of Chest Physicians (ACCP) recommend against the use of low-dose computed tomography (LDCT) for the general screening of lung cancer.

11 Sep 2007

Revlimid receives approval in Switzerland for treatment of multiple myeloma

Celgene International Sarl has announced that it's oral cancer drug, Revlimid (lenalidomide) has been granted approval by the Swiss Agency for Therapeutic Products (Swissmedic) for use in combination with dexamethasone as a treatment for patients with multiple myeloma who have received at least one prior therapy.

5 Sep 2007

Patent foramen ovale (PFO) and atrial septal defect (ASD) closure

A PFO and an ASD are congenital structural heart diseases characterized by a communication between heart chambers at the level of the wall (septum) separating them. These chambers are the left and right atrium as shown on the picture below. The right atrium receives (dark) oxygen-depleted blood from the great veins, while the left atrium receives (red) oxygen-rich blood from the lungs.

3 Sep 2007

Ambulatory oxygen rarely a benefit in COPD patients without resting hypoxemia

Prescribing ambulatory oxygen in patients with chronic obstructive pulmonary disease (COPD) improves exercise performance, but not the quality of their daily life unless they have resting hypoxemia, according to researchers in Toronto.

17 Aug 2007

Priority review granted for oral formulation of HYCAMTIN (topotecan)

GlaxoSmithKline (GSK) has announced that its new drug application (NDA) for ORAL HYCAMTIN (topotecan) capsules, a treatment for relapsed small cell lung cancer (SCLC), has been granted Priority Review by the United States Food and Drug Administration (FDA).

14 Jun 2007

Temsirolimus, effective new treatment for advanced renal cell carcinoma

The results of a phase III, randomized clinical study involving patients with advanced renal cell carcinoma and poor prognostic features show temsirolimus improved overall survival when compared to the current treatment for this stage of disease.

1 Jun 2007

New form of idiopathic pulmonary fibrosis found

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disorder from which most patients die within 5 years after diagnosis.

30 May 2007

New evidence-based guidelines for patients with chronic obstructive pulmonary disease

New evidence-based guidelines from the American College of Chest Physicians (ACCP) and the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR) recommend a comprehensive pulmonary rehabilitation program for patients with chronic obstructive pulmonary disease (COPD), citing that pulmonary rehabilitation can help improve a patient's exercise tolerance, dyspnea, and health-related quality of life, as well as decrease hospital stay and health-care utilization.

8 May 2007

Infliximab fails to improve chronic obstructive pulmonary disease symptoms

A promising anti-inflammatory drug failed to improve symptoms of moderate to severe chronic obstructive pulmonary disease, or COPD, in a large, multi-center trial.

2 May 2007

Levosimendan compared to dobutamine for decompensated heart failure

The drug levosimendan did not improve survival for patients with decompensated heart failure when compared with a more widely-used treatment for this condition, dobutamine, according to a study in the May 2 issue of JAMA.

2 May 2007

OncoGenex Technologies announces data from a Phase II clinical trial of OGX-011

The primary objective of this study was to assess the objective response rates (reduction in tumor size) when OGX-011 is combined with docetaxel in patients with metastatic or locally recurrent breast cancer.

18 Apr 2007

For overweight and obese individuals, the incidence of asthma increases by 50 percent

Asthma, a respiratory disease characterized by recurrent episodes of difficult breathing, wheezing, cough and thick mucus production, affected approximately 20.5 million Americans in 2004. Some common asthma triggers are allergic stimuli, infections, stress or strenuous exercise.

4 Apr 2007

Blood pressure control with Clevidipine

Researchers report that an investigational anti-hypertensive therapy may perform better in controlling blood pressure than standard treatments for patients undergoing heart surgery, during a presentation at the American College of Cardiology's 56th Annual Scientific Session.

30 Mar 2007

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