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Generating a mutation in key molecules could offer new way to prevent and treat gonorrhea

Creating a mutation that inhibits how the bacterial pathogen Neisseria gonorrhoeae causes gonorrhea, a common sexually transmitted infection, could offer a new way to prevent and treat the disease, according to researchers in the Institute for Biomedical Sciences at Georgia State University.

23 Sep 2022

All SARS-CoV-2 variants blocked by a simple peptide with nanomolar neutralizing efficacy

In a recent study published in the journal PNAS, researchers from Finland and the United States reported a novel heptad repeat 2 (HR2) peptide that inhibited severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) without any chemical modifications.

21 Sep 2022

Researchers report development of a self-assembled trimeric RBD subunit vaccine able to prevent SARS-CoV-2 infection

The present study reported the development of a new self-assembled trimeric RBD subunit vaccine that could effectively prevent infection from SARS-CoV-2 variants, including the currently dominantly circulating Omicron variant.

21 Sep 2022

Discovery of novel pathway offers a potential solution for preventing cancer chemo-resistance

Researchers have uncovered a novel pathway that explains how cancer cells become resistant to chemotherapies, which in turn offers a potential solution for preventing chemo-resistance.

20 Sep 2022

Novel method can be used to study the resistance profile of bacteria that cause meningitis

A study published in the journal PLOS ONE could one day help health workers determine whether bacteria of the species Streptococcus pneumoniae, which cause meningitis – an inflammation of the membranes that envelop the brain and spinal cord – are resistant to antibiotics.

6 Sep 2022

'Rippled beta sheet' protein structure created and characterized using x-ray crystallography

An unusual protein structure known as a "rippled beta sheet," first predicted in 1953, has now been created in the laboratory and characterized in detail using x-ray crystallography.

2 Sep 2022

Scientists explore nanomolar inhibition of SARS-CoV-2 infection via unmodified peptide targeting spike protein pre-hairpin intermediate

In a new study, scientists identified an unmodified peptide addressing pre-hairpin spike (S) protein intermediate inhibiting SARS-CoV-2 infection.

15 Aug 2022

Mechanistic insights into engineered ACE2 receptor traps

Researchers determined the cryo-electron microscopic (cryo-EM) structures of engineered angiotensin-converting enzyme 2 (ACE2) receptor traps.

12 Aug 2022

Study highlights the urgent need for combinatorial drug therapies for SARS-CoV-2

Researchers investigated the susceptibility of naturally-occurring severe acute respiratory syndrome coronavirus 2 main protease variants to protease inhibitor drugs, including nirmatrelvir and ensitrelvir.

11 Aug 2022

Scientists conduct comparative analysis of monkeypox virus profilin-like proteins and human profilin proteins

In a new study, researchers explored monkeypox virus proteomics and structural characteristics of the A42R protein, the only MPXV protein in the RCSB PDB (protein data bank) and the only profilin-like protein of poxviruses with known structure.

10 Aug 2022

Using microrobotic platforms for endodontic therapy and diagnostics

With its irregularities and anatomical complexities, the root canal system is one of the most clinically challenging spaces in the oral cavity.

9 Aug 2022

NIH researchers develop three-dimensional structure of twinkle protein

Researchers from the National Institutes of Health have developed a three-dimensional structure that allows them to see how and where disease mutations on the twinkle protein can lead to mitochondrial diseases.

5 Aug 2022

SARS-CoV-2 spike subunit 2–targeted vaccine could more effectively combat all human coronaviruses

In a new study, researchers evidenced that the S2 subunit of SARS-CoV-2 spike (S) could be an integral component of a pan-coronavirus vaccine.

29 Jul 2022

Study shows SARS-CoV-2 impairs interferon production through NSP2-induced repression of mRNA translation

Researchers discovered a SARS-CoV-2 non-structural protein 2 (NSP2)-mediated mechanism by which it suppresses the production of interferon-beta (IFN-β) in host cells.

27 Jul 2022

Cancer cells produce small amount of collagen that impacts tumor microbiome and immunity

Cancer cells produce small amounts of their own form of collagen, creating a unique extracellular matrix that affects the tumor microbiome and protects against immune responses, according to a new study by researchers at The University of Texas MD Anderson Cancer Center.

21 Jul 2022

Study determines the reason behind the failure of IVF embryos

In humans, a fertilized egg is no guarantee of reproductive success. Most embryos stop developing and perish within days of fertilization, usually because they have an abnormal number of chromosomes. Now, researchers at Columbia University Vagelos College of Physicians and Surgeons have found that most of these mistakes are due to spontaneous errors in DNA replication in the earliest phase of cell division.

20 Jul 2022

Helix News and Research

Generating a mutation in key molecules could offer new way to prevent and treat gonorrhea

All SARS-CoV-2 variants blocked by a simple peptide with nanomolar neutralizing efficacy

Researchers report development of a self-assembled trimeric RBD subunit vaccine able to prevent SARS-CoV-2 infection

Discovery of novel pathway offers a potential solution for preventing cancer chemo-resistance

Novel method can be used to study the resistance profile of bacteria that cause meningitis

'Rippled beta sheet' protein structure created and characterized using x-ray crystallography

Scientists explore nanomolar inhibition of SARS-CoV-2 infection via unmodified peptide targeting spike protein pre-hairpin intermediate

Mechanistic insights into engineered ACE2 receptor traps

Study highlights the urgent need for combinatorial drug therapies for SARS-CoV-2

Scientists conduct comparative analysis of monkeypox virus profilin-like proteins and human profilin proteins

Using microrobotic platforms for endodontic therapy and diagnostics

NIH researchers develop three-dimensional structure of twinkle protein

SARS-CoV-2 spike subunit 2–targeted vaccine could more effectively combat all human coronaviruses

Study shows SARS-CoV-2 impairs interferon production through NSP2-induced repression of mRNA translation

Cancer cells produce small amount of collagen that impacts tumor microbiome and immunity

Study determines the reason behind the failure of IVF embryos

Researchers identify fusion peptide-specific monoclonal antibodies with broad neutralizing activity

Urban areas with more natural spaces linked with better health behaviors in children

TRIM7 inhibits coxsackievirus and norovirus infection

Chicoric acid a potential candidate for COVID-19 treatment

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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