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Targeting SARS-CoV-2 with off-the-shelf CAR-NK cells

The current COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread and cause disease and death in many countries even today. At present, there is no effective treatment. A recent study published on the preprint server bioRxiv in August 2020 reports the potential of a new class of drugs called CAR NK cells, which could be used off-the-shelf to treat this disease.

17 Aug 2020

Potential inhibitors of SARS-CoV-2 identified

Now, a new study published on the preprint server bioRxiv in August 2020 reports the discovery of two inhibitors of the helicase enzyme, which is essential for viral replication and the most highly conserved non-structural coronavirus (CoV) protein.

16 Aug 2020

ARDS may not be the primary lung iInjury in COVID-19

A new Italian study published on the preprint server medRxiv in August 2020 shows that this may not be an adequate explanation, since ARDS is a nonspecific diagnosis. Instead, they say, antemortem lung biopsy shows a “Covid pattern” of acute lung injury, which could guide the application of therapeutics.

16 Aug 2020

Scientists reveal most likely order of COVID-19 symptoms

Now, a team of researchers at the University of Southern California (USC) has revealed the order of symptoms often experienced by those who infected with SARS-CoV-2. Knowing the order of the symptoms may help the patients seek medical help immediately. The research is published in the journal Frontiers in Public Health.

16 Aug 2020

U.S. scientists to create coronavirus strain for human challenge trials

Now, a team of scientists in the United States plans to create a coronavirus strain that can be used for human challenge trials, a controversial type of study wherein health volunteers would be vaccinated and intentionally infected with the virus.

16 Aug 2020

SARS-CoV-2 spike pocket is a putative target for antiviral design

In a methodologically rigorous study, researchers from the University of Oxford have recently shown how the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein harbors a lipid-binding pocket which modulates the stability of the prefusion trimer and provides conformational shielding from antibodies. Their findings are currently freely available on the bioRxiv* preprint server.

16 Aug 2020

COVID-19 virus acts as a 'sponge' to deplete specific host microRNAs

Why is the COVID-19 virus deadly, while many other coronaviruses are fairly innocuous and just cause colds?

15 Aug 2020

Influenza-virus-based vaccine platform another viable option against SARS-CoV-2

In a novel proof of concept study, published on the bioRxiv preprint server, U.S. researchers used attenuated influenza viral particles that express severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain to induce neutralizing antibodies in mice – unveiling another viable vaccine candidate for preventing coronavirus disease (COVID-19).

14 Aug 2020

COVID-19 pandemic as severe as 1918 influenza pandemic

A recent study published in the journal JAMA Network Open reveals that the excess death toll observed during the initial period of coronavirus disease 2019 (COVID-19) pandemic in New York City is comparable to that observed during the peak of the H1N1 influenza pandemic in 1918.

14 Aug 2020

Online calculator predicts patients’ risk for ischemic stroke

Doctors can predict patients' risk for ischemic stroke based on the severity of their metabolic syndrome, a conglomeration of conditions that includes high blood pressure, abnormal cholesterol levels and excess body fat around the abdomen and waist, a new study finds.

14 Aug 2020

Back to life: COVID lung transplant survivor tells her story

Mayra Ramirez remembers the nightmares. During six weeks on life support at Northwestern Memorial Hospital in Chicago, Ramirez said, she had terrifying nightmares that she couldn't distinguish from reality.

14 Aug 2020

Can SARS-CoV-2 die out without immunity?

As the COVID-19 pandemic continues to take thousands of lives every day in different parts of the world, vaccine and antiviral research is continuing, as the only hope of emergence from under its shadow. However, a recent study by researcher Bhavin S Khatri at Imperial College London and published on the preprint server medRxiv* in August 2020 suggests that the pandemic may die out more rapidly than thought, provided the reproduction number is kept low.

14 Aug 2020

COVID-19 during pregnancy shows no affect on placental structure and pathology

A new study published on the preprint server medRxiv in August 2020 shows that the placenta in pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) does not show any signs of abnormality that can be attributed to the infection.

14 Aug 2020

De novo designed SARS-CoV-2 nanoparticle vaccine

In light of the continuing threat to public health, social functioning, and economic activity posed by the COVID-19 pandemic, scientists are working urgently to bring out a vaccine that is both safe and effective, and capable of mass production. A new paper published on the preprint server bioRxiv* in August 2020 shows that such a vaccine may be produced by using arrays of one severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein on a nanoparticle platform.

14 Aug 2020

Experimental COVID-19 vaccine prevents severe disease in mice

Now, a novel experimental vaccine that is made from a mild virus genetically-modified to carry an essential gene from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the coronary disease (COVID-19), has shown promise in preventing pneumonia in mice infected with the virus.

14 Aug 2020

WHO urges the public to avoid routine dental work amid the coronavirus pandemic

With the cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) skyrocketing globally, the World Health Organization (WHO) is now warning the public to avoid routine dental procedures to reduce the risk of infection.

14 Aug 2020

Research shows how a protein stops cells from attacking their own DNA

Viruses multiply by injecting their DNA into a host cell. Once it enters the intracellular fluid, this foreign material triggers a defense mechanism known as the cGAS-STING pathway.

14 Aug 2020

Vaping raises COVID-19 risk among teens and youth

A new study by Californian researchers has shown that youth and teenagers who use electronic cigarettes are five times more likely to be affected by COVID-19 disease, and those that use both electronic and traditional cigarettes are seven times more likely to get the infection.

13 Aug 2020

JAK inhibitors or type I interferon shown to reduce mortality in COVID-19

Now, a new study by researchers at Yale University and published on the preprint server medRxiv in August 2020 reports that the use of two drug categories, namely, JAK inhibitors and Type I interferons (IFNs), is associated with a dramatic improvement in mortality in COVID-19.

13 Aug 2020

Membrane nanoparticles acts as a bait to trap SARS-CoV-2

In an exciting new bioRxiv preprint research paper, Chinese researchers describe the development of membrane nanoparticles from ACE2-rich cells with a potent capacity to block the adherence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

13 Aug 2020