Receptor News and Research

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Drug combo may have a greater impact on cancer development

Cancer researchers have long suggested that new targeted drugs may work best when paired with other therapies. In a new study published today in Cancer Research, scientists have taken some of the first steps to demonstrate this synergy in mouse and cell line models.

16 Sep 2004

Researchers are making inroads to understanding what makes brain tumors so hard to treat

When he's not in the operating room performing surgery, Donald M. O'Rourke, M.D., Associate Professor of Neurosurgery at the University of Pennsylvania School of Medicine is fighting brain tumors from the research laboratory bench.

16 Sep 2004

Researchers get a grip on marijuana

Now researchers at Stanford University School of Medicine are a step closer to understanding how the drug's active ingredients - tetrahydrocannabinol and related compounds, called cannabinoids - may exert their effects.

16 Sep 2004

HHS enhances Medicare drug card program to help seniors

Health and Human Services Secretary Tommy G. Thompson today announced new measures to help seniors get the lowest price possible for their medicines by allowing them -- for the first time -- to compare prices for similar drugs used to treat common diseases such as high cholesterol or blood pressure.

15 Sep 2004

Molecule that may be a primary cause of high blood pressure and link to diabetes

A study published in this week's Proceedings of the National Academy of Sciences identified the molecule that binds to a receptor (a molecule on the cell surface that triggers a reaction within the cell) in the brain that is known to regulate blood pressure and release of insulin.

14 Sep 2004

New biological principle and therapeutic goal for cancer treatment

Pioneering research on leukaemia cells can have identified their vulnerable spot. This new knowledge can now be used to produce more effective medicines.

14 Sep 2004

Sea urchins may provide clues to some baffling human reproductive problems

For many years scientists have believed they understood how closely related species that occupy the same regions of the ocean were kept from interbreeding. It turns out they were only seeing part of the picture.

13 Sep 2004

Gene linked to both alcoholism and depression

A national team of investigators led by psychiatric geneticists at Washington University School of Medicine in St. Louis has identified a gene that appears to be linked to both alcoholism and depression.

8 Sep 2004

Bird flu has jumped species barrier to cats

Now the United Nations health agency is investigating reports that bird flu, which experts say could mutate into a potentially deadly human pandemic under certain conditions, has now jumped the species barrier to infect cats.

4 Sep 2004

Women over 70 are safe to not have radiation treatment after heaving a lumpectomy

Two new studies reported in The New England Journal of Medicine suggest that older women with breast cancer are safe to not have radiation treatment after heaving a lumpectomy.

1 Sep 2004

International research sheds light on Escherichia coli

An unprecedented picture of how bacteria latch on to human cells has been published by UK, French and US scientists. They have produced a finely detailed model of one of the tools used by some of the nastiest varieties of the stomach bug, Escherichia coli, to stick to and gain entry to host cells.

1 Sep 2004

Study is the first comprehensive risk analysis to examine both the risk of death from breast cancer and other causes following diagnosis

Women who are diagnosed with breast cancer at a young age, or at an advanced stage at any age, are more likely to die from the disease than from all other causes of death combined, according to a new study by scientists at the National Cancer Institute.

1 Sep 2004

Study suggests that patients with pulmonary arterial hypertension may benefit from Thelin therapy

Encysive Pharmaceuticals today announced the presentation of data from a clinical study of Thelin(TM) (sitaxsentan) in pulmonary arterial hypertension (PAH), at the European Society of Cardiology Annual Congress in Munich.

31 Aug 2004

Angina drug nifedipine safe for long-term use

Calcium antagonists such as nifedipine are used to relieve the symptoms of angina, but there have been doubts about their long-term safety. However, ACTION--A Coronary disease Trial Investigating Outcome with Nifedipine GITS--provides new information on the drug's long-term use. GITS (gastrointestinal therapeutic system) modifies the release of the drug to provide stable long-term concentrations of nifedipine in blood.

30 Aug 2004

New study confirms benefits of rimonabant in weight loss

Phase III clinical study comparing placebo to rimonabant, the first agent in a new therapeutic class known as selective cannabinoid type 1 (CB1) blockers, showed that overweight or obese people taking rimonabant 20mg once daily benefited from a significant reduction in their body weight

29 Aug 2004

Phase 1 clinical trial of new anticancer drug from Human Genome Sciences

Human Genome Sciences has begun dosing patients in a Phase 1 clinical trial of HGS-TR2J, a novel agonistic human monoclonal antibody to TRAIL Receptor 2, in patients with advanced solid malignancies.

25 Aug 2004

Blueberries may lower cholesterol

New research from the U.S. Department of Agriculture shows that blueberries may lower cholesterol as effectively as a commercial drug and have the potential for fewer adverse side effects.

23 Aug 2004

Genmab's HuMax-CD4 receives U.S. orphan drug designation

Genmab has announced that HuMax-CD4 for the treatment of Mycosis Fungoides (MF), which constitutes 75% of all Cutaneous T-cell Lymphomas (CTCL), has been designated an orphan drug by the US Food and Drug Administration (FDA). The US prevalence of MF is estimated at 16,000 to 20,000.

23 Aug 2004

Novel disease mechanism underlying rheumatoid arthritis

Investigators at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) have identified a novel disease mechanism underlying rheumatoid arthritis that may open the door to new therapies for this and other debilitating autoimmune disorders.

23 Aug 2004

Genetic mutation link to sudden infant death syndrome

Researchers at Rush University Medical Center, and colleagues at the University of Pittsburgh have identified mutations in genes pertinent to the autonomic nervous system among babies who died of sudden infant death syndrome (SIDS) that might explain why they died.

21 Aug 2004