Syphilis News and Research

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Syphilis is a sexually transmitted disease (STD) caused by the bacterium Treponema pallidum. It has often been called “the great imitator” because so many of the signs and symptoms are indistinguishable from those of other diseases.

In the United States, health officials reported over 36,000 cases of syphilis in 2006, including 9,756 cases of primary and secondary (P&S) syphilis. In 2006, half of all P&S syphilis cases were reported from 20 counties and 2 cities; and most P&S syphilis cases occurred in persons 20 to 39 years of age. The incidence of P&S syphilis was highest in women 20 to 24 years of age and in men 35 to 39 years of age. Reported cases of congenital syphilis in newborns increased from 2005 to 2006, with 339 new cases reported in 2005 compared to 349 cases in 2006.

Between 2005 and 2006, the number of reported P&S syphilis cases increased 11.8 percent. P&S rates have increased in males each year between 2000 and 2006 from 2.6 to 5.7 and among females between 2004 and 2006. In 2006, 64% of the reported P&S syphilis cases were among men who have sex with men (MSM).

Syphilis is passed from person to person through direct contact with a syphilis sore. Sores occur mainly on the external genitals, vagina, anus, or in the rectum. Sores also can occur on the lips and in the mouth. Transmission of the organism occurs during vaginal, anal, or oral sex. Pregnant women with the disease can pass it to the babies they are carrying. Syphilis cannot be spread through contact with toilet seats, doorknobs, swimming pools, hot tubs, bathtubs, shared clothing, or eating utensils.
Delabeling penicillin allergy to improve syphilis care

Delabeling penicillin allergy to improve syphilis care

A review of clinical features, diagnosis, and management of Mpox

A review of clinical features, diagnosis, and management of Mpox

Doxycycline increases antimicrobial resistance in the gut without disrupting microbiome diversity

Doxycycline increases antimicrobial resistance in the gut without disrupting microbiome diversity

Study highlights benefits and risks of doxy-PEP for STI prevention

Study highlights benefits and risks of doxy-PEP for STI prevention

Spirituality and distrust influence Black patients' participation in cancer trials

Spirituality and distrust influence Black patients' participation in cancer trials

WHO calls for action to support adolescent mental and sexual health

WHO calls for action to support adolescent mental and sexual health

Collaborative study offers hope for syphilis vaccine development

Collaborative study offers hope for syphilis vaccine development

Single dose of MVA-BN vaccine offers 58% protection against mpox

Single dose of MVA-BN vaccine offers 58% protection against mpox

Single dose of MVA-BN vaccine shows 58% effectiveness against mpox

Single dose of MVA-BN vaccine shows 58% effectiveness against mpox

Boom, now bust: Budget cuts and layoffs take hold in public health

Boom, now bust: Budget cuts and layoffs take hold in public health

Breakthrough antibiotic targets gum disease without harming microbiome

Breakthrough antibiotic targets gum disease without harming microbiome

NIAID awards grants for 10 projects to improve diagnostic tools for syphilis

NIAID awards grants for 10 projects to improve diagnostic tools for syphilis

Healthcare workers unprepared for mpox outbreak due to knowledge gaps and vaccine inequity

Healthcare workers unprepared for mpox outbreak due to knowledge gaps and vaccine inequity

Native American public health officials are stuck in data blind spot

Native American public health officials are stuck in data blind spot

Human milk banks improve infant health but can't fully replace mother's milk

Human milk banks improve infant health but can't fully replace mother's milk

Rising syphilis cases highlight gaps in public knowledge on symptoms and treatment

Rising syphilis cases highlight gaps in public knowledge on symptoms and treatment

Complexities and emotional challenges of STI disclosure to sexual partners

Complexities and emotional challenges of STI disclosure to sexual partners

WHO report highlights rising STI rates and insufficient progress in HIV and hepatitis control

WHO report highlights rising STI rates and insufficient progress in HIV and hepatitis control

Washington University expands STI testing and treatment services in St. Louis County

Washington University expands STI testing and treatment services in St. Louis County

Rethinking PrEP's role in prevention of sexually transmitted infections

Rethinking PrEP's role in prevention of sexually transmitted infections

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