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Protein kinase complex influences the outer layer of skin to control the eventual shape of the full-grown skeleton and skull

Continuing studies about an important regulatory protein kinase complex called I-kappa-B kinase (or IKK) have now shown that a subunit of IKK – IKK alpha – influences the outer layer of skin in developing mice to control the eventual shape of the full-grown skeleton and skull.

7 Apr 2004

Molecular analyses of leukemia patients suggest strategies for better treatments

The cure rate for pediatric acute lymphoblastic leukemia (ALL) might continue to rise with improved use of conventional therapies. But even more effective and less toxic therapies based on genetic and pharmacogenetic studies might one day push the success rate close to 100 percent, according to an article published by investigators at St. Jude Children’s Research Hospital in the April 8 issue of the New England Journal of Medicine.

7 Apr 2004

Time-reversal acoustics research promises medical breakthroughs

Scientists have not yet found a way to actually make time run backward, but in the cutting-edge world of recent acoustics research, they have shown a way to make sound waves run backward in a kind of ultra-focused reverse echo. By the technology known as time-reversal acoustics, sound waves - in exact reverse order from the original sound - echo directly and very precisely back to their source point.

7 Apr 2004

FDA accepts REMICADE® (infliximab) for the treatment of early rheumatoid arthritis

Centocor, Inc., announced today that the U.S. Food and Drug Administration (FDA) has accepted its filing of a supplemental Biologics License Application (sBLA) for REMICADE® (infliximab) as first-line therapy, in combination with methotrexate, for the treatment of early rheumatoid arthritis (RA) patients with moderately-to-severely active disease. REMICADE®, in combination with methotrexate, is currently indicated in the U.S. for reducing signs and symptoms, inhibiting the progression of structural damage and improving physical function in patients with moderately-to-severely active RA who have had an inadequate response to methotrexate alone.

6 Apr 2004

New method to induce embryonic stem cells to develop into bone marrow and blood cells

Researchers at Northwestern University have devised a method to induce embryonic stem cells to develop into bone marrow and blood cells. Injecting the stem cells into the bone marrow cavity of mice whose bone marrow cells had been depleted restored production of blood cells, including cells of the immune system, which normally are created in the bone marrow.

6 Apr 2004

Phase 3 study of drug teduglutide in patients with short bowel syndrome

Teduglutide is an analog of glucagon-like peptide 2 (GLP-2), a naturally occurring hormone that regulates the growth, proliferation and maintenance of cells lining the gastrointestinal tract. Teduglutide has been shown in animal studies and previous human clinical trials to increase the size and number of these cells, thereby increasing the absorptive surface area of the intestines.

6 Apr 2004

More evidence needed to link symptoms like tics or behavioral problems to a strep infection

Surgeons suggests that the development of osteoarthritis in the knee following an injury may be both predictable and preventable

A new theory of joint function presented in a symposium at the 71st annual meeting of the American Academy of Orthopaedic Surgeons suggests that the development of osteoarthritis in the knee following an injury may be both predictable and preventable.

5 Apr 2004

New center enables genetic treatments and advances

A new state-of-the-art research facility dedicated to helping produce modified cells for treatment of cancer and other diseases recently opened at the Siteman Cancer Center.

1 Apr 2004

Gene of immune system linked to severe adverse drug reaction called Stevens-Johnson syndrome (SJS)

In a study of Han Chinese patients, researchers have for the first time directly linked a gene of the immune system to a severe adverse drug reaction called Stevens-Johnson syndrome (SJS), according to a Duke University Medical Center medical geneticist and collaborators in Taiwan.

1 Apr 2004

Sheffield University pioneers osteoporosis research

A leading osteoporosis expert from Sheffield has been awarded the prestigious Society for Endocrinology Medal and the Kohn Foundation Award for his 25-year commitment to revolutionising the treatment and diagnosis of osteoporosis.

31 Mar 2004

How rat's genetic blueprint stacks up against those of mice and humans

An international research team, supported by the National Institutes of Health (NIH), today announced it has completed a high-quality, draft sequence of the genome of the laboratory rat, and has used that data to explore how the rat's genetic blueprint stacks up against those of mice and humans.

31 Mar 2004

Discovery of gender difference in cartilage cells may help spinal disc repair

When biologist Barbara Boyan discovered science’s first proof of biochemical differences between male and female cartilage cells, she began to question the approaches she and other researchers were taking to study cells. Was their thinking biologically relevant?

30 Mar 2004

Emerging technologies in tissue engineering and regenerative medicine analysis

Pathbreaking developments in tissue engineering and regenerative therapies are facilitating the design and growth of new organs in labs using biopolymer scaffolds and matrices. Analysis of potential markets for tissue engineering reveals that basic problems such as vascularity must be solved before such implants can gain acceptance as standard treatment methods.

30 Mar 2004

First North American sales of Raycell X-ray blood irradiator

The Indiana Blood Center in Indianapolis, Indiana, and SMDC Laboratory in Duluth, Minnesota have both chosen to purchase MDS Nordion's Raycell(TM) blood irradiator as a means of eliminating delays in receiving irradiated blood and blood products from external suppliers and improving the service they provide to physicians and patients.

30 Mar 2004

Method of Bone Analysis May Clarify Human Origins

Bones, it is said, tell tales, but in the case of the bones of hominids or human ancestors the story has become complex and convoluted, as paleoanthropologists try to decipher relationships between a host of similar species with subtly shifting characteristics in a spotty fossil record.

30 Mar 2004

$Study demonstrates pharmacists ability to identify & refer patients at-risk for fractures$

Study demonstrates pharmacists ability to identify & refer patients at-risk for fractures

Results from Project ImPACT: Osteoporosis were discussed today during the Annual Meeting of the American Pharmacists Association. Published in the March/April 2004 issue of the Journal of the American Pharmacists Association the authors, Jean-Venable “Kelly” Goode, Kim Swiger, and Benjamin M. Bluml, suggest that when patients, pharmacists and physicians collaborate closely, using pharmacy-based testing to identify and refer patients who are at-risk for future fracture that breakthrough results are possible.

28 Mar 2004

Children with sickle cell disease are living longer, dying less often from their disease

Children with sickle cell disease, an inherited red blood-cell disorder, are living longer, dying less often from their disease and contracting fewer fatal infections than ever before, researchers at UT Southwestern Medical Center at Dallas report. Their study, which will appear in the June edition of the scientific journal Blood, is the first to evaluate survival rates of children receiving the most modern treatments for sickle cell disease. It's also one of the largest published sickle cell studies to date. Researchers followed more than 700 Dallas-area children with the disease over two decades.

25 Mar 2004

Approval for FOSRENOL (lanthanum carbonate), which controls phosphate levels in renal dialysis patients

Sweden's MPA has today granted the first regulatory approval in the world for FOSRENOL (lanthanum carbonate), a non-calcium, non-aluminium phosphate binding medicine developed to control phosphate levels in renal dialysis patients. Sweden will now become the Reference Member State in the EU Mutual Recognition Procedure for FOSRENOL, and this is the first step in securing marketing approval throughout Europe. A submission has also been made by Shire to gain marketing approval for FOSRENOL in the United States.

25 Mar 2004

Bone marrow stem cells do not help regenerate heart muscle tissue, UW study finds, contradicting earlier study

Researchers at the University of Washington School of Medicine have found that bone marrow stem cells do not convert into heart muscle cells in mice. These results contradict a study conducted elsewhere that had prompted human clinical trials for such stem cell therapy in the treatment of heart attack.

23 Mar 2004

Bone News and Research

Protein kinase complex influences the outer layer of skin to control the eventual shape of the full-grown skeleton and skull

Molecular analyses of leukemia patients suggest strategies for better treatments

Time-reversal acoustics research promises medical breakthroughs

FDA accepts REMICADE® (infliximab) for the treatment of early rheumatoid arthritis

New method to induce embryonic stem cells to develop into bone marrow and blood cells

Phase 3 study of drug teduglutide in patients with short bowel syndrome

More evidence needed to link symptoms like tics or behavioral problems to a strep infection

Surgeons suggests that the development of osteoarthritis in the knee following an injury may be both predictable and preventable

New center enables genetic treatments and advances

Gene of immune system linked to severe adverse drug reaction called Stevens-Johnson syndrome (SJS)

Sheffield University pioneers osteoporosis research

How rat's genetic blueprint stacks up against those of mice and humans

Discovery of gender difference in cartilage cells may help spinal disc repair

Emerging technologies in tissue engineering and regenerative medicine analysis

First North American sales of Raycell X-ray blood irradiator

Method of Bone Analysis May Clarify Human Origins

Study demonstrates pharmacists ability to identify & refer patients at-risk for fractures

Children with sickle cell disease are living longer, dying less often from their disease

Approval for FOSRENOL (lanthanum carbonate), which controls phosphate levels in renal dialysis patients

Bone marrow stem cells do not help regenerate heart muscle tissue, UW study finds, contradicting earlier study

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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