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World's first gene therapy trial aimed at preventing cancer

The concept seems straightforward. If, at its heart, cancer is a disease of genes, then giving patients new genes should disarm cancer. Such treatment would replace missing or faulty genes that keep cell growth in check, or would flush the body with "super genes" that could attack and destroy cancer.

5 May 2004

Trial of antibody for HIV Infection

Tanox, Inc. announced today that it has begun dosing patients in its Phase 2 clinical trial of TNX-355 for the treatment of the human immunodeficiency virus (HIV).

5 May 2004

Agreement expands Quintiles capabilities to support drug approvals in Japan

Quintiles Transnational Corp. today announced an agreement to conduct clinical trials in Peru involving ethnic Japanese, further expanding the company's ability to support new drug applications in Japan.

5 May 2004

First drug product for treatment of short bowel syndrome

Short bowel syndrome (SBS) is a rare and potentially life-threatening condition in which the ability of the small intestine to absorb the nutrition a person needs from food is impaired. Short bowel syndrome can occur after surgical removal of part of the intestine, due to trauma or because the intestine is diseased.

4 May 2004

Study suggests that the vitamins, such as E, C, and beta carotene, could raise bad form of cholesterol

The notion that antioxidant vitamins could provide a safe, convenient way to protect the heart from disease appears to have hit a pothole.

3 May 2004

Wyeth gets FDA approval for a novel protein device that enhances bone healing

Wyeth have announced that the FDA has approved rhBMP-2/ACS (recombinant human Bone Morphogenetic Protein-2/Absorbable Collagen Sponge), a novel protein device that enhances bone healing, for use in the treatment of acute, open tibia shaft fractures in adults.

3 May 2004

Intranasal influenza vaccine may help induce broader immunity in children than the traditional flu shot

MedImmune, Inc. has announced clinical data showing that a live, attenuated intranasal influenza vaccine (LAIV) may help induce broader immunity in children against drifted influenza strains when compared to the traditional flu shot (TIV).

2 May 2004

FDA approves new drug Enbrel for psoriasis

The U.S. Food and Drug Administration has approved the biologic drug etanercept (brand name Enbrel) to treat chronic, moderate to severe plaque psoriasis in adults.

1 May 2004

Gene therapy may delay Alzheimer progression

Results from a preliminary eight-patient study of gene therapy for Alzheimer’s disease are positive enough to justify a larger clinical trial, Mark H. Tuszynski, M.D., Ph.D., reported April 27 at the 56th Annual Meeting of the American Academy of Neurology. Dr. Tuszynski says that a larger trial is being planned at a major medical center in Chicago.

30 Apr 2004

Mutation of a gene involved in non-small cell lung cancer linked to drug effectiveness

Mutation of a gene involved in non-small cell lung cancer (NSCLC) increases the likelihood that the drug gefitinib (Iressa™) will show a beneficial response, researchers at the Dana-Farber Cancer Institute, the National Cancer Institute (NCI) - part of the National Institutes of Health - and two other institutions announced today in the online version of Science.

29 Apr 2004

Study shows prostate brachytherapy using ‘Radioactive Seeds’ is an effective alterantive to surgery or external radiation

Radiation oncologists and urologists at The Cleveland Clinic have performed their 1,000th prostate brachytherapy, a type of treatment in which radioactive seeds are implanted in the prostate to destroy cancerous cells.

28 Apr 2004

$Untreated postmenopausal women with osteoporosis are at risk for first spinal fracture within one year$

Untreated postmenopausal women with osteoporosis are at risk for first spinal fracture within one year

Results of a new analysis found that, without treatment, one out of 13 postmenopausal osteoporotic women who were initially fracture-free were likely to experience a spinal fracture within one year.

28 Apr 2004

Inspire announces positive results in cystic fibrosis study

Inspire Pharmaceuticals, Inc. today announced top-line results in a Phase II study of INS37217 Respiratory in patients with mild cystic fibrosis (CF) lung disease.

27 Apr 2004

Alzheimer’s drug has been shown to improve memory and cognition in multiple sclerosis (MS) patients

A drug widely used for treating dementia in Alzheimer’s patients has been shown to improve memory and cognition in multiple sclerosis (MS) patients who are mild to moderately cognitively impaired.

26 Apr 2004

Clinical trial of enzyme replacement therapy for the treatment of Gaucher disease

Transkaryotic Therapies, Inc. today announced that it has initiated a clinical trial to evaluate the safety and clinical activity of GA-GCB, its enzyme replacement therapy for the treatment of Gaucher disease.

26 Apr 2004

Polio victory remembered on 50th anniversary of Salk Vaccine field trials

Fifty years ago today, thousands of parents drove their school-age children to designated sites across the country for immunizations of an experimental vaccine that they hoped would stop, once and for all, the raging polio epidemic that was leaving young Americans paralyzed and sometimes dead. Organized and funded by the March of Dimes, this was the largest voluntary clinical trial ever undertaken.

26 Apr 2004

Spice turmeric corrects the cystic fibrosis defect

Scientists at The Hospital for Sick Children (Sick Kids) and Yale University School of Medicine have found that a compound in the spice turmeric corrects the cystic fibrosis defect in mice. This research is reported in the April 23, 2004 issue of the journal Science.

24 Apr 2004