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Study provides insights into the epidemiology and genetics of clonal hematopoiesis

A comprehensive new study from deCODE genetics, a subsidiary of Amgen, published today in Nature Genetics, provides insights into the epidemiology and somatic and germline genetics of clonal hematopoiesis.

7 Nov 2023

New blood test revolutionizes early cancer detection in Li-Fraumeni Syndrome patients

Canadian researchers develop a cell-free DNA-based multimodal assay for early cancer detection in patients with Li-Fraumeni Syndrome, a high-cancer-risk condition. The assay outperforms conventional methods, promising more sensitive and less invasive cancer surveillance.

29 Oct 2023

Precision oncology therapies account for nearly half of new cancer drug approvals since 1998

Of the 198 new oncology drugs approved by the U.S. Food and Drug Administration (FDA) between 1998 and 2022, approximately 43% were precision oncology therapies, the use of which is guided by biomarker testing.

18 Oct 2023

Could metformin be a game changer for heart health in non-diabetics?

Using Mendelian randomization, researchers found that altering seven metformin targets led to improved blood pressure and BMI in non-diabetic individuals. The study suggests the potential for metformin's role in reducing cardiovascular risks in the general population, although more research is needed.

24 Sep 2023

Scientists identify mutations in 11 genes associated with aggressive forms of prostate cancer

An international research team led by scientists in the Center for Genetic Epidemiology at the Keck School of Medicine of USC and USC Norris Comprehensive Cancer Center has singled out mutations in 11 genes that are associated with aggressive forms of prostate cancer.

21 Sep 2023

Scientists uncover potential key risk factors for melanomas in children and adolescents

A recent eBioMedicine study found key risk factors associated with the development of melanoma in children and adolescents.

19 Sep 2023

Mitochondrial GTP metabolism acts through mitochondrial dynamics factors to regulate reproductive aging

Reproductive aging in Caenorhabditis elegans is regulated through an interaction of the metabolism of mitochondrial guanosine-triphosphate.

18 Sep 2023

VAI scientists uncover mechanism that annotates genetic information passed from fathers to offspring

Van Andel Institute scientists and collaborators have identified a key part of a mechanism that annotates genetic information before it is passed from fathers to their offspring.

7 Sep 2023

The Clinical Importance of Circulating Tumor DNA

Cancer remains a leading killer among medical causes of death worldwide.

31 Aug 2023

Study finds that germline-encoded specificities cannot always predict the trajectory of B-cell responses

Researchers used computational simulations and experiments to investigate how genetic variations encoded in the germline impact B-cell responses.

29 Aug 2023

Fruit fly study provides insights into piRNA production and fertility

You're likely familiar with RNA, the molecule that plays an important role in protein production and gene expression control.

9 Aug 2023

Genome editing in the spotlight: genetic disorder carriers' views shape the conversation

Study explores perspectives on the applications of somatic genome editing.

8 Aug 2023

AI-based predictive tool could help guide treatment of cancer

Researchers at Dana-Farber Cancer Institute have created an AI-based tool that uses tumor gene sequencing data to predict the primary source of a patient's cancer.

7 Aug 2023

Computational model can help identify the sites of origin for enigmatic cancers

For a small percentage of cancer patients, doctors are unable to determine where their cancer originated. This makes it much more difficult to choose a treatment for those patients, because many cancer drugs are typically developed for specific cancer types.

7 Aug 2023

The roles and plausible mechanisms of pyroptosis in renal inflammation and fibrosis

Researchers summarize available data on pyroptosis in the context of renal fibrosis, as well as its prevention and treatment.

1 Aug 2023

Universal genetic testing may improve risk stratification and treatment for rare and lethal cancer

Esophageal adenocarcinoma (EAC) is a highly lethal cancer, with a five-year survival rate of less than 20 percent. Although a precursor lesion to EAC, called Barrett's esophagus (BE), is present in roughly seven percent of middle-aged adults, less than one percent of BE patients will progress to EAC, making it difficult to determine which individuals are at risk of developing this deadly cancer.

27 Jul 2023

Germline News and Research

Study provides insights into the epidemiology and genetics of clonal hematopoiesis

New blood test revolutionizes early cancer detection in Li-Fraumeni Syndrome patients

Precision oncology therapies account for nearly half of new cancer drug approvals since 1998

Could metformin be a game changer for heart health in non-diabetics?

Scientists identify mutations in 11 genes associated with aggressive forms of prostate cancer

Scientists uncover potential key risk factors for melanomas in children and adolescents

Mitochondrial GTP metabolism acts through mitochondrial dynamics factors to regulate reproductive aging

VAI scientists uncover mechanism that annotates genetic information passed from fathers to offspring

The Clinical Importance of Circulating Tumor DNA

Study finds that germline-encoded specificities cannot always predict the trajectory of B-cell responses

Fruit fly study provides insights into piRNA production and fertility

Genome editing in the spotlight: genetic disorder carriers' views shape the conversation

AI-based predictive tool could help guide treatment of cancer

Computational model can help identify the sites of origin for enigmatic cancers

The roles and plausible mechanisms of pyroptosis in renal inflammation and fibrosis

Universal genetic testing may improve risk stratification and treatment for rare and lethal cancer

Core promoter variation may drive development of triple-negative breast cancer

Addressing research gaps: The UK's efforts to study lung cancer in never smokers

Breast cancer and MEN1: exploring the connection

Uncovering the hidden genetic connections behind COVID-19 and comorbidities

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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